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Your search keyword '"Teixeira, José A."' showing total 1,846 results
Start Over Author "Teixeira, José A." Publication Type Academic Journals
1,846 results on '"Teixeira, José A."'

1. Effects of high-intensity and progressive volume resistance training on functional, mental states, and quality of life of people with spinal cord injury

Author

Rodrigues, Joel Alves, Pereira, Eveline Torres, Lopes, Jaqueline Salgado, Teixeira, Robson Bonoto, da Silva, Sandro Fernandes, Aidar, Felipe José, de Oliveira, Claudia Eliza Patrocínio, da Encarnação, Samuel Gonçalves Almeida, Forte, Pedro, Teixeira, José Eduardo, Monteiro, António Miguel, and Moreira, Osvaldo Costa

Published
2024
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17. Decision Support System for the Selection of Students for Erasmus+ Short-Term Mobility

Author

Teixeira, José, Alves, Sandro, Mariz, Pedro, and Almeida, Fernando

Abstract

Purpose: The current student selection process for short-term mobility actions under the Erasmus + program (i.e. intensive programs and blended intensive programs) is based exclusively on the students' order of enrolment and their grades. This study offers an alternative approach using the analytic hierarchy process based on a four-layer model that collects information about the specificities of each project and the profile of the students and also promotes greater inclusion and homogenization of the project teams. Design/methodology/approach: A decision support system was built by decomposing it into three stages--the predesign stage, in which the problem is characterized, and the user requirements are identified; the design stage, in which the models, the database and the interfaces are formulated; and the field stage, in which six test scenarios were built to validate the proposed solution. Findings: The results show that this model can be applied with various selection criteria among students and consider both their hard and soft skills. It can also be applied to help build teams in which the students' knowledge is aligned with the technical skills required by the projects. Originality/value: The proposed approach is innovative in that it responds to the emerging challenge of short-term European mobility programs that aim to involve students with multidisciplinary competencies. The solution considers both hard and soft skills in the selection of students, which allows changing the student selection paradigm and obtaining potentially more homogeneous multicultural teams with greater learning potential.

Published
2023
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29. Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content

Author

Papes, Fabio, Camargo, Antonio P, de Souza, Janaina S, Carvalho, Vinicius MA, Szeto, Ryan A, LaMontagne, Erin, Teixeira, José R, Avansini, Simoni H, Sánchez-Sánchez, Sandra M, Nakahara, Thiago S, Santo, Carolina N, Wu, Wei, Yao, Hang, Araújo, Barbara MP, Velho, Paulo ENF, Haddad, Gabriel G, and Muotri, Alysson R

Subjects
Information and Computing Sciences, Biomedical and Clinical Sciences, Machine Learning, Stem Cell Research, Neurosciences, Pediatric, Genetics, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Mental Health, Stem Cell Research - Nonembryonic - Human, Brain Disorders, Intellectual and Developmental Disabilities (IDD), 2.1 Biological and endogenous factors, Aetiology, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Neurological, Cell Proliferation, Child, Humans, Hyperventilation, Intellectual Disability, Neurons, Transcription Factor 4
Abstract

Transcription Factor 4 (TCF4) has been associated with autism, schizophrenia, and other neuropsychiatric disorders. However, how pathological TCF4 mutations affect the human neural tissue is poorly understood. Here, we derive neural progenitor cells, neurons, and brain organoids from skin fibroblasts obtained from children with Pitt-Hopkins Syndrome carrying clinically relevant mutations in TCF4. We show that neural progenitors bearing these mutations have reduced proliferation and impaired capacity to differentiate into neurons. We identify a mechanism through which TCF4 loss-of-function leads to decreased Wnt signaling and then to diminished expression of SOX genes, culminating in reduced progenitor proliferation in vitro. Moreover, we show reduced cortical neuron content and impaired electrical activity in the patient-derived organoids, phenotypes that were rescued after correction of TCF4 expression or by pharmacological modulation of Wnt signaling. This work delineates pathological mechanisms in neural cells harboring TCF4 mutations and provides a potential target for therapeutic strategies for genetic disorders associated with this gene.

Published
2022

33. Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism

Author

Amorim, Ricardo, Magalhães, Carina C., Benfeito, Sofia, Cagide, Fernando, Tavares, Ludgero C., Santos, Katia, Sardão, Vilma A., Datta, Sandipan, Cortopassi, Gino A., Baldeiras, Inês, Jones, John G., Borges, Fernanda, Oliveira, Paulo J., and Teixeira, José

Published
2024
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44. Transcription factor 4 and its association with psychiatric disorders.

Author

Teixeira, José R, Szeto, Ryan A, Carvalho, Vinicius MA, Muotri, Alysson R, and Papes, Fabio

Subjects
Clinical Sciences, Public Health and Health Services, Psychology
Abstract

The human transcription factor 4 gene (TCF4) encodes a helix-loop-helix transcription factor widely expressed throughout the body and during neural development. Mutations in TCF4 cause a devastating autism spectrum disorder known as Pitt-Hopkins syndrome, characterized by a range of aberrant phenotypes including severe intellectual disability, absence of speech, delayed cognitive and motor development, and dysmorphic features. Moreover, polymorphisms in TCF4 have been associated with schizophrenia and other psychiatric and neurological conditions. Details about how TCF4 genetic variants are linked to these diseases and the role of TCF4 during neural development are only now beginning to emerge. Here, we provide a comprehensive review of the functions of TCF4 and its protein products at both the cellular and organismic levels, as well as a description of pathophysiological mechanisms associated with this gene.

Published
2021

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