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Your search keyword '"Varga, M."' showing total 1,173 results
Start Over Author "Varga, M." Publication Type Academic Journals
1,173 results on '"Varga, M."'

4. Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score

Author

Dajti, I, Valenzuela, JI, Boccalatte, LA, Gemelli, NA, Smith, DE, Dudi-Venkata, NN, Kroon, HM, Sammour, T, Roberts, M, Mitchell, D, Lah, K, Pearce, A, Morton, A, Dawson, AC, Drane, A, Sharpin, C, Nataraja, RM, Pacilli, M, Cox, DRA, Muralidharan, V, Riddiough, GE, Clarke, EM, Jamel, W, Qin, KR, Pockney, P, Cope, D, Egoroff, N, Lott, N, Putnis, S, De Robles, S, Ang, Z, Mitteregger, M, Uranitsch, S, Stiegler, M, Seitinger, G, Aigner, F, Lumenta, DB, Nischwitz, PS, Richtig, E, Pau, M, Srekl-Filzmaier, P, Eibinger, N, Michelitsch, B, Fediuk, M, Papinutti, A, Seidel, G, Kahn, J, Cohnert, TU, Messner, D, Öfner, F, Presl, J, Varga, M, Weitzendorfer, M, Emmanuel, K, Binder, AD, Zimmermann, M, Holawe, S, Nkenke, E, Grimm, C, Kranawetter, M, Rahman Mitul, A, Islam, N, Karim, S, Komen, N, Ang, E, De Praetere, H, Tollens, T, Schols, G, Smets, C, Haenen, L, Quintens, J, Van Belle, K, Van Ramshorst, GH, Pattyn, P, Desender, L, Martens, T, Van de Putte, D, Lerut, P, Grimonprez, A, Janssen, M, De Smul, G, Wallaert, P, Van den Eynde, J, Oosterlinck, W, Van den Eynde, R, Sermon, A, Boeckxstaens, A, Cordonnier, A, De Coster, J, Jaekers, J, Politis, C, Miserez, M, Duchateau, N, De Gheldere, C, Flamey, N, Christiano, A, and Guidi, B

Subjects
Clinical Research, Patient Safety, Vaccine Related, Biodefense, Prevention, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, COVID-19, Cohort Studies, Datasets as Topic, Humans, Machine Learning, Models, Statistical, Risk Assessment, SARS-CoV-2, Surgical Procedures, Operative, COVIDSurg Collaborative, Medical and Health Sciences, Surgery
Abstract

To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.app). Our data demonstrates that it is safe to restart a wide range of surgical services for selected patients.

Published
2021

21. Histological Scoring Systems in the Cartilage Repair of Sheep

Author

Gullberg S., Simaiová V., Holovská K., Luptaková L., Koľvek F., Varga M., and Petrovová E.

Subjects
animal model, articular cartilage, cartilage repair, histology, regeneration, scoring system, Veterinary medicine, SF600-1100
Abstract

Researchers around the world use histological analysis to provide the most detailed morphological information of articular cartilage repair and it predominantly relies on the use of histological scoring systems which are important tools for valid evaluations. Due to hyaline cartilage complex structure and avascular nature, damaged cartilage does not heal spontaneously and it is still a challenge to regenerate and restore its tissue function. The aim of this study was to investigate the quality of regenerated cartilage by using three different histological scoring systems; O’Driscoll, Pineda and Wakitani which are all classic scores described for such animal studies. We used an in vivo ovine model in which a full thickness chondral defect was created and then implanted with the biomaterial (polyhydroxybutyrate/chitosan; PHB/ CHIT). The results of this histological analysis demonstrated that the cartilage repaired tissues received scores indicating that the majority of the regenerated tissue resembled hyaline-like cartilage. After six months of repair the regenerated cartilage showed characteristics like good surface continuity, uniformed stained extracellular matrix, clearly visible zones and cellular proliferation. In conclusion, this study may be used to investigate and improve the regenerative capacity of hyaline cartilage in preclinical models and it also sheds further light on both the evaluation and methods used for the regeneration of damaged cartilage.

Published
2019
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45. Osteogenic cell differentiation on H-terminated and O-terminated nanocrystalline diamond films

Author

Liskova J, Babchenko O, Varga M, Kromka A, Hadraba D, Svindrych Z, Burdikova Z, and Bacakova L

Subjects
Medicine (General), R5-920
Abstract

Jana Liskova,1 Oleg Babchenko,2 Marian Varga,2 Alexander Kromka,2 Daniel Hadraba,1 Zdenek Svindrych,1 Zuzana Burdikova,1 Lucie Bacakova1 1Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 2Institute of Physics, Academy of Sciences of the Czech Republic, Prague, Czech Republic Abstract: Nanocrystalline diamond (NCD) films are promising materials for bone implant coatings because of their biocompatibility, chemical resistance, and mechanical hardness. Moreover, NCD wettability can be tailored by grafting specific atoms. The NCD films used in this study were grown on silicon substrates by microwave plasma-enhanced chemical vapor deposition and grafted by hydrogen atoms (H-termination) or oxygen atoms (O-termination). Human osteoblast-like Saos-2 cells were used for biological studies on H-terminated and O-terminated NCD films. The adhesion, growth, and subsequent differentiation of the osteoblasts on NCD films were examined, and the extracellular matrix production and composition were quantified. The osteoblasts that had been cultivated on the O-terminated NCD films exhibited a higher growth rate than those grown on the H-terminated NCD films. The mature collagen fibers were detected in Saos-2 cells on both the H-terminated and O-terminated NCD films; however, the quantity of total collagen in the extracellular matrix was higher on the O-terminated NCD films, as were the amounts of calcium deposition and alkaline phosphatase activity. Nevertheless, the expression of genes for osteogenic markers – type I collagen, alkaline phosphatase, and osteocalcin – was either comparable on the H-terminated and O-terminated films or even lower on the O-terminated films. In conclusion, the higher wettability of the O-terminated NCD films is promising for adhesion and growth of osteoblasts. In addition, the O-terminated surface also seems to support the deposition of extracellular matrix proteins and extracellular matrix mineralization, and this is promising for better osteoconductivity of potential bone implant coatings. Keywords: nanocrystalline diamond film, osteoblast, Saos-2, collagen, SHG

Published
2015

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