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Your search keyword '"WATAI, TAKAYUKI"' showing total 3 results
Start Over Author "WATAI, TAKAYUKI" Publication Type Academic Journals
3 results on '"WATAI, TAKAYUKI"'

3. Neurotoxicity of acetaldehyde-derived advanced glycation end products for cultured cortical neurons.

Author

Takeuchi M, Watai T, Sasaki N, Choei H, Iwaki M, Ashizawa T, Inagaki Y, Yamagishi S, Kikuchi S, Riederer P, Saito T, Bucala R, and Kameda Y

Subjects
Acetaldehyde chemistry, Acetaldehyde metabolism, Albumins metabolism, Alcoholism metabolism, Alcoholism pathology, Animals, Antibodies metabolism, Apoptosis physiology, Cattle, Cells, Cultured, Cerebral Cortex cytology, Glycation End Products, Advanced chemistry, Glycation End Products, Advanced metabolism, Humans, Neurons cytology, Neurons metabolism, Rabbits, Rats, Acetaldehyde toxicity, Cerebral Cortex metabolism, Glycation End Products, Advanced toxicity, Neurons drug effects
Abstract

The Maillard reaction that leads to the formation of advanced glycation end products (AGEs) plays an important role in the pathogenesis of angiopathy in diabetic patients, in aging, and in neurodegenerative processes. We hypothesize that acetaldehyde (AA), one of the main metabolites of alcohol, may be involved in alcohol-induced neurotoxicity in vivo by formation of AA-derived AGEs (AA-AGEs) with brain proteins. Incubation of cortical neurons with AA-AGE produced a dose-dependent increase in neuronal cell-death, and the neurotoxicity of AA-AGE was neutralized by the addition of an anti-AA-AGE-specific antibody, but not by anti-N-ethyllysine (NEL) antibody. The AA-AGE epitope was detected in human brain of alcoholism. We propose that the structural epitope AA-AGE is an important toxic moiety for neuronal cells in alcoholism.

Published
2003
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