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With the rapid development of the information age, big data technology has been widely penetrated into various industries, and has brought profound impact on its structure and operation mode. In the field of music education, big data provides advanced tools and platforms for teaching, and provides a new perspective for the formulation of music teaching strategies and the sharing of educational resources. The purpose of this study is to deeply study the music teaching strategies based on big data and make a comparative analysis with traditional strategies. Based on an extensive literature review, this study summarizes the basic concepts, core features and applications of big data in music teaching. In order to have a more comprehensive understanding of the actual effects of big data in music teaching, we designed a series of experiments to compare the performance of music teaching strategies based on big data and traditional strategies in terms of student learning outcomes, learning engagement, student satisfaction, teaching progress and efficiency. The results show that the music teaching strategy based on big data can better meet the personalized learning needs of students, improve the learning engagement, and significantly improve the teaching effect and the quality of resource sharing. This study provides scientific ideas and methods for music teaching, and hopefully provides beneficial enlightenment for the application of big data technology in the field of education. [ABSTRACT FROM AUTHOR]

The spatial characteristics, pollution sources, and risks of soil heavy metals were analyzed on Hainan Island. The results showed that the heavily polluted points accounted for 0.56%, and the number of mildly and above polluted points accounted for 15.27%, respectively, which were mainly distributed in the northern part of the study area. The principal component analysis–absolute principal component score–multiple linear regression (APCS-MLR) and the positive matrix factorization (PMF) revealed four sources of heavy metals: agricultural pollution sources for cadmium, (Cd), industrial and mining pollution sources for arsenic, (As), transportation pollution sources for zinc and lead (Zn and Pb), and natural pollution sources for chromium, nickel, and copper (Cr, Ni, and Cu). The human health risk assessment indicated that the average non-carcinogenic risk (HI) for both adults and children was within the safe threshold (<1), whereas Cr and Ni posed a carcinogenic risk (CR) to human health. In addition, the total non-carcinogenic risk (THI) indicated that heavy metals posed a potential non-carcinogenic risk to children, while the total carcinogenic risk (TCR) remained relatively high, mainly in the northern part of the study area. The results of the Monte Carlo simulation showed that the non-carcinogenic risk (HI) for all heavy metals was <1, but the total non-carcinogenic risk index (THI) for children was >1, indicating a potential health risk above the safe threshold. Meanwhile, nearly 100% and 99.94% of the TCR values exceeded 1 × 10−4 for children and adults, indicating that Cr and Ni are priority heavy metals for control. The research results provide the necessary scientific basis for the prevention and control of heavy metals in agricultural soils. [ABSTRACT FROM AUTHOR]

Safety problems caused by organophosphorus pesticide (OP) residues are constantly occurring, so the development of new methods for the degradation and detection of OPs is of great scientific significance. In the present study, β-sheet peptides and β-hairpin peptides for catalyzing the hydrolysis of OPs were designed and synthesized. The peptide sequences with the highest hydrolytic activity (EHSGGVTVDPPLTVEHSAG) were screened by investigating the effect of the location of the active sites of the peptide and the peptide's structure on the degradation of OPs. In addition, the relationship between the peptides' conformation and hydrolytic activity was further analyzed based on density functional theory calculations. The noncovalent interactions of the peptides with the OPs and the electrostatic potential on the molecular surface and molecular docking properties were also investigated. It was found that peptides with approximate active amino acids consisting of the catalytic triad and with the hairpin structure had enhanced hydrolytic activity toward the hydrolysis of OPs. To develop an electrochemical sensor technique to detect OPs, the conductive MXene (Ti3C2) material was first immobilized with a caffeic acid monolayer via enediol–metal complex chemistry and then bound with the β-hairpin peptide (EHSGGVTVDPPLTVEHSAG) via carboxy–amine condensation chemistry between the –COOH of caffeic acid and the –NH2 of the peptide to prepare a MXene–peptide composite. Then, the prepared composite was modified on the surface of a glassy carbon electrode to construct an electrochemical sensor for the detection of OPs. The developed technique could be used to monitor OPs within 15 min with a two orders of linear working range and with a detection limit of 0.15 μM. Meanwhile, the sensor showed good reliability for the detection of OPs in real vegetables. [ABSTRACT FROM AUTHOR]

This article describes a customized early reading intervention for a Chinese first grader at risk for failing to learn to read. Building upon observational notes, artifacts, diagnostic teaching, information about classroom performance, and a battery of tests, our goal is to provide insights into ways to develop and implement a one-on-one tutoring program with nonalphabetic readers. The child's progress demonstrated that one-on-one tutoring can appreciably raise the proficiency of a struggling Chinese reader, suggesting that one-on-one tutoring might be worthwhile for the lowest-achieving students learning to read a nonalphabetic writing system. (Contains 5 tables and 3 figures.)

Surface-enhanced Raman spectroscopy (SERS) has emerged as an indispensable analytical tool in biomolecular research, providing unmatched sensitivity critical for the elucidation of biomolecular structures. This review presents a thorough examination of SERS, outlining its fundamental principles, cataloging its varied applications within the biomolecular sphere, and contemplating its future developmental trajectories. We begin with a detailed analysis of SERS's mechanistic principles, emphasizing both the phenomena of surface enhancement and the complexities inherent in Raman scattering spectroscopy. Subsequently, we delve into the pivotal role of SERS in the structural analysis of diverse biomolecules, including proteins, nucleic acids, lipids, carbohydrates, and biochromes. The remarkable capabilities of SERS extend beyond mere detection, offering profound insights into biomolecular configurations and interactions, thereby enriching our comprehension of intricate biological processes. This review also sheds light on the application of SERS in real-time monitoring of various bio-relevant compounds, from enzymes and coenzymes to metal ion-chelate complexes and cellular organelles, thereby providing a holistic view and empowering researchers to unravel the complexities of biological systems. We also address the current challenges faced by SERS, such as enhancing sensitivity and resolution, developing stable and reproducible substrates, and conducting thorough analyses in complex biological matrices. Nonetheless, the continual advancements in nanotechnology and spectroscopy solidify the standing of SERS as a formidable force in biomolecular research. In conclusion, the versatility and robustness of SERS not only deepen our understanding of biomolecular intricacies but also pave the way for significant developments in medical research, therapeutic innovation, and diagnostic approaches. [ABSTRACT FROM AUTHOR]

A facile and novel method was established for the synthesis of triazolinone scaffolds through [3 + 2] cycloaddition of C,N-cycloazomethylimines with dioxazolones in the presence of CH3ONa. In these transformations, isocyanates were formed in situ by the decarboxylation and Curtius rearrangement of dioxazolones. Importantly, the isocyanate formed from dioxazolone is employed for the first time for the cyclization instead of the widely used N-acyl nitrenes. The newly developed [3 + 2] cycloaddition is applicable to a broad range of substrates with high functional group tolerance, providing various triazolinones in good to excellent yields (up to 94%). Additionally, this method is easy to operate, green, environmentally friendly, and avoids highly toxic reagents. [ABSTRACT FROM AUTHOR]

The national policy in deaf education in Mainland China primarily focuses on oral/aural instruction and hearing rehabilitation. The curriculum in primary grades is specifically structured on speech and hearing skills for language development. But there is little evidence that documents what early literacy instruction looks like or how teachers conduct the teaching of reading and writing in classrooms with Chinese deaf children. By analyzing videotapes from the first and second grade classrooms, we describe how reading and writing are taught to deaf children in China. The key findings are that the primary grade literacy instruction (1) shares features of Gradual Release of Responsibility model with a focus on speech and hearing skills; (2) uses multimodal strategies and pedagogical tools such as lip-reading, Pinyin phonetic symbols, Pinyin Finger Spelling, Chinese Sign Language (CSL), and Signed Chinese (SC). Moreover, the curriculum reflects low expectations for deaf students as it lacks the academic content provided to their hearing peers. We conclude with implications for literacy instruction in deaf education, and suggest a future research agenda.