Search

Metal oxides are often used as electrode materials for supercapacitors because of their high capacity， low cost， suitability for commercialization， and environmental friendliness. In this study， Mn-MOF was used as a precursor and placed in ethanol for ion exchange and etching reaction with Co（NO3）2， followed by heat treatment in air， and finally highly crystalline CoMn2O4 two-dimensional nanorod structures were obtained on a carbon cloth（CC） substrate. SEM and XRD analyses of CoMn2O4/CC prepared with different Co（NO3）2 additions and Mn2O3/CC obtained by direct heat treatment were performed， and electrochemical properties were measured by cyclic voltammetry test， constant current charge/discharge test and AC impedance test. The results show that the parent structure of CoMn2O4/CC is relatively well preserved after 0.3 g Co（NO3）2 etching， forming a nano-hollow structure， and the vertical nanorod structures grow in situ on carbon cloth after heat treatment wrapping carbon fibers uniformly and densely， ensuring high mechanical stability and electrical conductivity due to the absence of any binder addition. The electrode material has an area specific capacitance of 809.8 mF·cm-2 at the current density of 1.2 mA·cm-2 and the capacitance retention is 79.1% after 5000 cycles at the current density of 5 mA·cm-2，showing potential application prospects.

In order to study the corrosion resistance of three different superhydrophobic coatings (MZS-1, MZS-2 and ZnO@ZIF-8) on AZ91D magnesium alloy surface in 5% (mass fraction) NaCl solution. The microstructure, wettability and corrosion resistance of the superhydrophobic composite coating were tested and characterized by field emission scanning electron microscope, static contact angle tester, electrochemical workstation and salt spray tester, respectively. The results show that the corrosion of the superhydrophobic coatings does not occur until 192 h after salt spray treatment among the three types of superhydrophobic coatings, and the corrosion of the MZS-1 superhydrophobic coating is the most serious. The surface pitting of the MZS-2 superhydrophobic coating doesn't occur until 240 h later, and the contact angle is still high after salt spray treatment, so the corrosion resistance of the MZS-2 composite coating is the best.The polarization curve tests indicate that the corrosion current density of three superhydrophobic coatings are still one order of magnitude lower than that of the metal matrix after salt spray treatment for 240 h, showing excellent corrosion resistance. The superhydrophobic coating can effectively increase the corrosion resistance of metal materials.It can effectively prevent the infiltration of corrosive ions and provide long-term protection for the matrix because of its water repellency.

Despite numerous observational studies indicating an increased risk of cutaneous melanoma (CM) due to childhood sunburn, no studies have established a definitive cause‐and‐effect relationship. Therefore, our objective was to employ a Mendelian randomization (MR) design to explore a possible causal association between childhood sunburn and the risk of CM. To investigate the causal relationship between childhood sunburn and CM, we used large‐scale genetic summary‐level data from genome‐wide association studies (GWAS), including childhood sunburn (n = 346,955) and CM (n = 262,288), building upon previous observational studies. In the analysis, we mainly used the inverse‐variance weighted (IVW) method of the random effects model, supplemented by the weighted median method and MR‐Egger method. The results of the IVW method demonstrated that genetically predicted childhood sunburn was significantly associated with higher odds of CM, with an odds ratio (OR) of 2.418 (95%CI, 1.426–4.099; p =.001). The weighted median method and MR‐Egger regression also demonstrated directionally similar results (both p <.05). Furthermore, both the funnel plot and the MR‐Egger intercepts showed the absence of directional pleiotropy between childhood sunburn and CM. Our study offers potential evidence linking genetically predicted childhood sunburn with CM, underscoring the need for individuals with a history of childhood sunburn to be extra vigilant regarding the occurrence of CM. [ABSTRACT FROM AUTHOR]

Obesity can activate the inflammatory signal pathway, induce in the body a state of chronic inflammation, and increase the excitability of the sympathetic nervous system, which may induce sympathetic neuropathic injury. The stellate sympathetic ganglia (SG) can express the P2X4 receptor, and the abnormal expression of the P2X4 receptor is related to inflammation. Imperatorin (IMP) is a kind of furan coumarin plant which has anti-inflammatory effects. This project aimed to investigate whether IMP can affect the expression of P2X4 receptors in the SG of obese rats to display a protective effect from high-fat-triggered cardiac sympathetic neuropathic injury. Molecular docking through homology modelling revealed that IMP had good affinity for the P2X4 receptor. Our results showed that compared with the normal group, the administration of IMP or P2X4 shRNA decreased sympathetic excitement; reduced the serum levels of triglyceride, total cholesterol, and lactate dehydrogenase; downregulated the expression of P2X4 receptors in SG; and inhibited the expression of inflammatory factors in the SG and serum of obese rats significantly. In addition, the expression of factors associated with the cell pyroptosis GSDMD, caspase-1, NLRP-3, and IL-18 in obese rats were significantly higher than those of the normal rats, and such effects were decreased after treatment with IMP or P2X4 shRNA. Furthermore, IMP significantly reduced the ATP-activated currents in HEK293 cells transfected with P2X4 receptor. Thus, the P2X4 receptor may be a key target for the treatment of obesity-induced cardiac sympathetic excitement. IMP can improve obesity-induced cardiac sympathetic excitement, and its mechanism of action may be related to the inhibition of P2X4 receptor expression and activity in the SG, suppression of cellular pyroptosis in the SG, and reduction of inflammatory factor levels. [ABSTRACT FROM AUTHOR]