562 results on '"Whisstock, James C"'
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2. Proteoform-Resolved Profiling of Plasminogen Activation Reveals Novel Abundant Phosphorylation Site and Primary N-Terminal Cleavage Site
3. Fragment-based and structure-guided discovery of perforin inhibitors
4. The role of NINJ1 protein in programmed cellular destruction
5. Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
6. A mechanism for hereditary angioedema caused by a lysine 311–to–glutamic acid substitution in plasminogen
7. Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
8. Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
9. The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1
10. Mapping the binding site of C1-inhibitor for polyanion cofactors
11. Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
12. Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin
13. Stonefish toxin defines an ancient branch of the perforin-like superfamily
14. OpenFIBSEM: A universal API for FIBSEM control
15. The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
16. A High-Throughput Small-Angle X-ray Scattering Assay to Determine the Conformational Change of Plasminogen.
17. Homodimerization attenuates the anti-inflammatory activity of interleukin-37
18. Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3
19. The first transmembrane region of complement component-9 acts as a brake on its self-assembly
20. PhosContext2vec: a distributed representation of residue-level sequence contexts and its application to general and kinase-specific phosphorylation site prediction
21. Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
22. Torso-like functions independently of Torso to regulate Drosophila growth and developmental timing
23. Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
24. IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
25. X-ray crystal structure of the streptococcal specific phage lysin PlyC
26. Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
27. Structure of the Plasmodium falciparum M17 Aminopeptidase and Significance for the Design of Drugs Targeting the Neutral Exopeptidases
28. Temperature Sensitivity of Human Perforin Mutants Unmasks Subtotal Loss of Cytotoxicity, Delayed FHL, and a Predisposition to Cancer
29. Structure of Granzyme C Reveals an Unusual Mechanism of Protease Autoinhibition
30. Structural Basis for the Inhibition of the Essential Plasmodium falciparum M1 Neutral Aminopeptidase
31. Smoothing a rugged protein folding landscape by sequence-based redesign
32. A Common Fold Mediates Vertebrate Defense and Bacterial Attack
33. TcpM: a novel relaxase that mediates transfer of large conjugative plasmids from Clostridium perfringens
34. Structural determinants of GAD antigenicity
35. Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation.
36. Macrophage self‐renewal is regulated by transient expression of PDGF‐ and VEGF‐related factor 2.
37. Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
38. The structural basis for membrane binding and pore formation by lymphocyte perforin
39. Cascleave 2.0, a new approach for predicting caspase and granzyme cleavage targets
40. The major human and mouse granzymes are structurally and functionally divergent
41. AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP
42. The Evolution of Enzyme Specificity in Fasciola spp.
43. Mining folded proteomes in the era of accurate structure prediction.
44. Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(sub)1-antitrypsin to inhibit cathepsin proteases
45. Probing the role of the F-helix in Serpin stability through a single tryptophan substitution
46. The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases
47. Predicting giant transmembrane β-barrel architecture
48. Efficient large-scale protein sequence comparison and gene matching to identify orthologs and co-orthologs
49. The conjugation protein TcpC from Clostridium perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria
50. Automatic generation of protein structure cartoons with Pro-origami
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