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591 results on '"Wotherspoon, Andrew"'

7. Prognostic and predictive impact of sex in locally advanced microsatellite instability high gastric or gastroesophageal junction cancer: An individual patient data pooled analysis of randomized clinical trials

Author

Raimondi, Alessandra, Kim, Young Woo, Kang, Won Ki, Langley, Ruth E., Choi, Yoon Young, Kim, Kyoung-Mee, Nankivell, Matthew Guy, Randon, Giovanni, Kook, Myeong-Cherl, An, Ji Yeong, Grabsch, Heike I., Prisciandaro, Michele, Nichetti, Federico, Noh, Sung Hoon, Sohn, Tae Sung, Kim, Sung, Wotherspoon, Andrew, Morano, Federica, Cunningham, David, Lee, Jeeyun, Cheong, Jae-Ho, Smyth, Elizabeth Catherine, and Pietrantonio, Filippo

Published
2024
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8. A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications

Author

El-Sharkawi, Dima, Sud, Amit, Prodger, Catherine, Khwaja, Jahanzaib, Shotton, Rohan, Hanley, Brian, Peacock, Victoria, Peng, Ying Ying, Arasaretnam, Anita, Sharma, Sarkhara, Aldridge, Frances, Sharma, Bhupinder, Wotherspoon, Andrew, Cheung, Betty, De Lord, Corinne, Johnston, Rosalynd, Kassam, Shireen, Pettengel, Ruth, Linton, Kim, Greaves, Paul, Cook, Lucy, Naresh, Kikkeri N., Cwynarski, Kate, Eyre, Toby A., Chau, Ian, Cunningham, David, and Iyengar, Sunil

Published
2023
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10. Unraveling the genetics of transformed splenic marginal zone lymphoma

Author

Grau, Marta, López, Cristina, Navarro, Alba, Frigola, Gerard, Nadeu, Ferran, Clot, Guillem, Bastidas-Mora, Gabriela, Alcoceba, Miguel, Baptista, Maria Joao, Blanes, Margarita, Colomer, Dolors, Costa, Dolors, Domingo-Domènech, Eva, Enjuanes, Anna, Escoda, Lourdes, Forcada, Pilar, Giné, Eva, Lopez-Guerra, Mónica, Ramón, Olga, Rivas-Delgado, Alfredo, Vicente Folch, Laura, Wotherspoon, Andrew, Climent, Fina, Campo, Elias, López-Guillermo, Armando, Matutes, Estella, and Beà, Sílvia

Published
2023
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11. Improving outcomes of childhood and young adult non-Hodgkin lymphoma: 25 years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma

Author

Beishuizen, Auke, Mellgren, Karin, Andrés, Mara, Auperin, Anne, Bacon, Chris M, Bomken, Simon, Burke, G A Amos, Burkhardt, Birgit, Brugieres, Laurence, Chiang, Alan K S, Damm-Welk, Christine, d'Amore, Emanuele, Horibe, Keizo, Kabickova, Edita, Khanam, Tasneem, Kontny, Udo, Klapper, Wolfram, Lamant, Laurence, Le Deley, Marie-Cecile, Loeffen, Jan, Macintyre, Elizabeth, Mann, Georg, Meyer-Wentrup, Friederike, Michgehl, Ulf, Minard-Colin, Veronique, Mussolin, Lara, Oschlies, Ilske, Patte, Catherine, Pillon, Marta, Reiter, Alfred, Rigaud, Charlotte, Ronceray, Leila, Salaverria, Itziar, Simonitsch-Klupp, Ingrid, Uyttebroeck, Anne, Verdu-Amoros, Jaime, Williams, Denise, Woessmann, Wilhelm, Wotherspoon, Andrew, Wrobel, Grazyna, Zimmermann, Martin, Attarbaschi, Andishe, and Turner, Suzanne D

Published
2023
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16. Epstein–Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship

Author

Medeiros, L. Jeffrey, Marques-Piubelli, Mario L., Sangiorgio, Valentina F.I., Ruiz-Cordero, Roberto, Vega, Francisco, Feldman, Andrew L., Chapman, Jennifer R., Clemens, Mark W., Hunt, Kelly K., Evans, Mark G., Khoo, Christine, Lade, Stephen, Silberman, Mark, Morkowski, Jerzy, Pina, Edward M., Mills, Daniel C., Bates, Christopher M., Magno, Winston B., Sohani, Aliyah R., Sieling, Beth A., O'Donoghue, Joseph M., Bacon, Chris M., Patani, Neill, Televantou, Despina, Turner, Suzanne D., Johnson, Laura, MacNeill, Fiona, Wotherspoon, Andrew C., Iyer, Swaminathan P., Malpica, Luis E., Patel, Keyur P., Xu, Jie, and Miranda, Roberto N.

Published
2021
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18. Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage

Author

Carotenuto, Pietro, Amato, Francesco, Lampis, Andrea, Rae, Colin, Hedayat, Somaieh, Previdi, Maria C., Zito, Domenico, Raj, Maya, Guzzardo, Vincenza, Sclafani, Francesco, Lanese, Andrea, Parisi, Claudia, Vicentini, Caterina, Said-Huntingford, Ian, Hahne, Jens C., Hallsworth, Albert, Kirkin, Vladimir, Young, Kate, Begum, Ruwaida, Wotherspoon, Andrew, Kouvelakis, Kyriakos, Azevedo, Sergio Xavier, Michalarea, Vasiliki, Upstill-Goddard, Rosie, Rao, Sheela, Watkins, David, Starling, Naureen, Sadanandam, Anguraj, Chang, David K., Biankin, Andrew V., Jamieson, Nigel B., Scarpa, Aldo, Cunningham, David, Chau, Ian, Workman, Paul, Fassan, Matteo, Valeri, Nicola, and Braconi, Chiara

Published
2021
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19. Clonal diversity of MYC amplification evaluated by fluorescent in situ hybridisation and digital droplet polymerase chain reaction in oesophagogastric cancer: Results from a prospective clinical trial screening programme

Author

Davidson, Michael, Aronson, Lauren I., Howard-Reeves, Julie, Bryant, Hanna, Cutts, Rosalind J., Hulkki-Wilson, Sanna, Kouvelakis, Kyriakos, Kalaitzaki, Eftheleria, Watkins, David, Starling, Naureen, Rao, Sheela, Cardenosa, Marta Llorca, Begum, Ruwaida, Rana, Isma, Lazaro-Alcausi, Retchel, Terlizzo, Monica, Wotherspoon, Andrew, Brown, Gina, Swansbury, John, Lord, Christopher J., Cunningham, David, Chau, Ian, and Chong, Irene Y.

Published
2019
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21. Progressive TP53 inactivation in an aggressive splenic diffuse red pulp small B-cell lymphoma.

Author

Tzioni, Maria-Myrsini, Clipson, Alexandra, Chen, Zi, Cucco, Francesco, Wotherspoon, Andrew, Dojcinov, Stefan, and Du, Ming-Qing

Subjects
DIFFUSE large B-cell lymphomas, LYMPHOMAS, MUCOSA-associated lymphoid tissue lymphoma, HAIRY cell leukemia, NUCLEOTIDE sequencing, SOMATIC mutation
Abstract

Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is a rare type of lymphoma that affects the spleen, bone marrow, and peripheral blood. It was initially thought to be a variant of splenic marginal zone lymphoma (SMZL) but is now recognized as a separate entity. SDRPL is difficult to diagnose based on peripheral blood and bone marrow samples alone, and a splenectomy is often necessary for an accurate diagnosis. The pathogenesis of SDRPL is not well understood, but it is associated with specific genetic changes, including mutations in BCOR, CCND3, NOTCH pathway genes, and MAP2K1. The prognosis and treatment response of SDRPL vary, but TP53 inactivation, through mutation and/or deletion, is associated with an aggressive clinical course. [Extracted from the article]

Published
2024
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22. A wolf in sheep's clothing: enteropathy associated T‐cell lymphoma involving a nasal polyp masquerading as primary mucosal CD30‐positive T‐cell lymphoproliferative disorder.

Author

Attygalle, Ayoma D, Vroobel, Katherine M, Madej, Ewelina, Tzioni, Maria‐Myrsini, Zhang, Chunye, Chen, Zi, Ribeiro, Sara, Calvachini, Silvia, Sharma, Bhupinder, Alexander, Emma J, Wotherspoon, Andrew C, and Du, Ming‐Qing

Subjects
T-cell lymphoma, LYMPHOPROLIFERATIVE disorders, NASAL polyps, INTESTINAL diseases, ANAPLASTIC large-cell lymphoma
Abstract

This article discusses a case study of an 81-year-old woman who presented with nose bleeds and a nasal polyp. The biopsy revealed features of anaplastic large-cell lymphoma (ALCL), but further testing showed that the diagnosis was actually enteropathy-associated T-cell lymphoma (EATL) involving the nasal polyp. The patient also had a history of coeliac disease (CD) and jejunal resection revealed EATL and refractory coeliac disease type 2 (RCD2). The article highlights the challenges in diagnosing and distinguishing between different types of lymphomas and emphasizes the importance of clinical correlation and awareness of relevant clinical details. The patient received treatment but unfortunately died 9 months after the initial presentation. [Extracted from the article]

Published
2024
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23. Ataxia Telangiectasia Mutated Protein Loss and Benefit From Oxaliplatin-based Chemotherapy in Colorectal Cancer

Author

Sundar, Raghav, Miranda, Susana, Rodrigues, Daniel Nava, Chénard-Poirier, Maxime, Dolling, David, Clarke, Matthew, Figueiredo, Ines, Bertan, Claudia, Yuan, Wei, Ferreira, Ana, Chistova, Rossitza, Boysen, Gunther, Perez, Desamparados Roda, Tunariu, Nina, Mateo, Joaquin, Wotherspoon, Andrew, Chau, Ian, Cunningham, David, Valeri, Nicola, Carreira, Suzanne, and de Bono, Johann

Published
2018
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24. CHOP versus GEM-P in previously untreated patients with peripheral T-cell lymphoma (CHEMO-T): a phase 2, multicentre, randomised, open-label trial

Author

Gleeson, Mary, Peckitt, Clare, To, Ye Mong, Edwards, Laurice, Oates, Jacqueline, Wotherspoon, Andrew, Attygalle, Ayoma D, Zerizer, Imene, Sharma, Bhupinder, Chua, Sue, Begum, Ruwaida, Chau, Ian, Johnson, Peter, Ardeshna, Kirit M, Hawkes, Eliza A, Macheta, Marian P, Collins, Graham P, Radford, John, Forbes, Adam, Hart, Alistair, Montoto, Silvia, McKay, Pamela, Benstead, Kim, Morley, Nicholas, Kalakonda, Nagesh, Hasan, Yasmin, Turner, Deborah, and Cunningham, David

Published
2018
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25. Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

Author

Harrington, Kevin, Melcher, Alan, Wotherspoon, Andrew, Francis, Nicholas, Challacombe, Ben, Fernando, Archana, Hazell, Steve, Chandra, Ashish, Pickering, Lisa, Lynch, Joanna, Rudman, Sarah, Chowdhury, Simon, Harrison-Phipps, Karen, Varia, Mary, Horsfield, Catherine, Polson, Alexander, Stamp, Gordon, O'Donnell, Marie, Drake, William, Hill, Peter, Hrouda, David, Mayer, Eric, Olsburgh, Jonathan, Kooiman, Gordon, O'Connor, Kevin, Stewart, Grant, Aitchison, Michael, Tran, Maxine, Fotiadis, Nicos, Verma, Hema, Lopez, Jose, Lester, Jason, Morgan, Fiona, Kornaszewska, Malgorzata, Attanoos, Richard, Adams, Haydn, Davies, Helen, Fennell, Dean, Shaw, Jacqui, Le Quesne, John, Nakas, Apostolos, Rathinam, Sridhar, Monteiro, William, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Riley, Joan, Primrose, Lindsay, Martinson, Luke, Anand, Girija, Khan, Sajid, Nicolson, Marianne, Kerr, Keith, Palmer, Shirley, Remmen, Hardy, Miller, Joy, Buchan, Keith, Chetty, Mahendran, Gomersall, Lesley, Lock, Sara, Naidu, Babu, Langman, Gerald, Trotter, Simon, Bellamy, Mary, Bancroft, Hollie, Kerr, Amy, Kadiri, Salma, Webb, Joanne, Middleton, Gary, Djearaman, Madava, Summers, Yvonne, Califano, Raffaele, Taylor, Paul, Shah, Rajesh, Krysiak, Piotr, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Evison, Matthew, Crosbie, Phil, Moss, Stuart, Idries, Faiza, Novasio, Juliette, Joseph, Leena, Bishop, Paul, Chaturvedi, Anshuman, Marie Quinn, Anne, Doran, Helen, leek, Angela, Harrison, Phil, Moore, Katrina, Waddington, Rachael, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Brady, Ged, Rothwell, Dominic, Gulati, Sakshi, Chemie, Francesca, Tugwood, Jonathan, Pierce, Jackie, Lawrence, David, Hayward, Martin, Panagiotopoulos, Nikolaos, George, Robert, Patrini, Davide, Falzon, Mary, Borg, Elaine, Khiroya, Reena, Jamal-Hanjani, Mariam, Wilson, Gareth, Juul Birkbak, Nicolai, Watkins, Thomas, McGranahan, Nicholas, Abbosh, Christopher, Horswell, Stuart, Mitter, Richard, Escudero, Mickael, Stewart, Aengus, Rowan, Andrew, Hiley, Crispin, Goldman, Jacki, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Shaw, Penny, Veeriah, Raju, Czyzewska-Khan, Justyna, Johnson, Diana, Laycock, Joanne, Hynds, Robert, Werner Sunderland, Mariana, Reading, James, Novelli, Marco, Oukrif, Dahmane, Janes, Sam, Forster, Martin, Ahmad, Tanya, Ming Lee, Siow, van Loo, Peter, Herrero, Javier, Hartley, John, Kevin Stone, Richard, Denner, Tamara, Costa, Marta, Begum, Sharmin, Phillimore, Ben, Chambers, Tim, Nye, Emma, Ward, Sophie, Elgar, Greg, Al-Bakir, Maise, Carnell, Dawn, Mendes, Ruheena, George, Jeremy, Navani, Neal, Papadatos-Pastos, Dionysis, Scarci, Marco, Gorman, Pat, Lowe, Helen, Ensell, Leah, Moore, David, MacKenzie, Mairead, Wilcox, Maggie, Bell, Harriet, Hackshaw, Allan, Ngai, Yenting, Smith, Sean, Gower, Nicole, Ottensmeier, Christian, Chee, Serena, Johnson, Benjamin, Alzetani, Aiman, Shaw, Emily, Lim, Eric, De Sousa, Paulo, Tavares Barbosa, Monica, Nicholson, Andrew, Bowman, Alex, Jordan, Simon, Rice, Alexandra, Raubenheimer, Hilgardt, Proli, Chiara, Elena Cufari, Maria, Carlo Ronquillo, John, Kwayie, Angela, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Ambrose, Lyn, Devaraj, Anand, Buderi, Silviu, Finch, Jonathan, Azcarate, Leire, Chavan, Hema, Green, Sophie, Mashinga, Hillaria, Lau, Kelvin, Sheaff, Michael, Schmid, Peter, Conibear, John, Ezhil, Veni, Prakash, Vineet, Danson, Sarah, Bury, Jonathan, Edwards, John, Hill, Jennifer, Matthews, Sue, Kitsanta, Yota, Suvarna, Kim, Shackcloth, Michael, Gosney, John, Postmus, Pieter, Feeney, Sarah, Asante-Siaw, Julius, Russell, Peter, Light, Teresa, Horey, Tracey, Blyth, Kevin, Dick, Craig, Kirk, Alan, Arce Vargas, Frederick, Furness, Andrew J.S., Litchfield, Kevin, Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Solomon, Isabelle, Lesko, Marta H., Ruef, Nora, Roddie, Claire, Henry, Jake Y., Spain, Lavinia, Ben Aissa, Assma, Georgiou, Andrew, Wong, Yien Ning Sophia, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, O'Brien, Tim, Mårtensson, Linda, Ljungars, Anne, Teige, Ingrid, Frendéus, Björn, Pule, Martin, Marafioti, Teresa, Gore, Martin, Larkin, James, Turajlic, Samra, Swanton, Charles, Peggs, Karl S., and Quezada, Sergio A.

Published
2018
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26. MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

Author

Lampis, Andrea, Carotenuto, Pietro, Vlachogiannis, Georgios, Cascione, Luciano, Hedayat, Somaieh, Burke, Rosemary, Clarke, Paul, Bosma, Else, Simbolo, Michele, Scarpa, Aldo, Yu, Sijia, Cole, Rebecca, Smyth, Elizabeth, Mateos, Javier Fernández, Begum, Ruwaida, Hezelova, Blanka, Eltahir, Zakaria, Wotherspoon, Andrew, Fotiadis, Nicos, Bali, Maria Antonietta, Nepal, Chirag, Khan, Khurum, Stubbs, Mark, Hahne, Jens C., Gasparini, Pierluigi, Guzzardo, Vincenza, Croce, Carlo M., Eccles, Suzanne, Fassan, Matteo, Cunningham, David, Andersen, Jesper B., Workman, Paul, Valeri, Nicola, and Braconi, Chiara

Published
2018
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28. Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme

Author

Lindsay, Colin R., Shaw, Emily C., Blackhall, Fiona, Blyth, Kevin G., Brenton, James D., Chaturvedi, Anshuman, Clarke, Noel, Dick, Craig, Evans, Thomas R.J., Hall, Geoff, Hanby, Andrew M., Harrison, David J., Johnston, Stephen R.D., Mason, Malcolm D., Morton, Dion, Newton-Bishop, Julia, Nicholson, Andrew G., Oien, Karin A., Popat, Sanjay, Rassl, Doris, Sharpe, Rowena, Taniere, Phillipe, Walker, Ian, Wallace, William A., West, Nicholas P., Butler, Rachel, Gonzalez de Castro, David, Griffiths, Mike, Johnson, Peter W.M., Rehal, Pauline, Butler, Samantha, Smith, Matthew, Doak, Rachel, Tanska, Anna, Halford, Graham, James, Lisa, Kotara, Chris, Masson, Gareth, Clokie, Sam, Bell, Jennie, Macdonald, Fiona, De Castro, David Gonzalez, Thompson, Lisa, Mair, Debbie, Lillis, Suzanne, Wren, Dorte, Hollifield, Robert, Dover, Keeda, Maurya, Manisha, Brooks, Damian, Gomez, Belen, Grady, Lisa, Jones, Thomas, Hooper, Chantal, Webster, Daphne, Travis, Jolyon, Ogwuru, Stephanie, Gazdova, Jana, Collins, Denise, Chapman, Elaine, Leavey, Lisa, Proszek, Paula, Hulkki, Sanna, Collins, V.Peter, Ibrahim, Ash, Brown, Kat, Burge, Jo, Burnett, Karen, Devonshire, Ginny, Moseley, Ellen, Haynes, Bev, Hodgkin, Charlotte, Jimenez-linan, Merche, Jones, Linda, Kenyon, Gilly, Mahler-araujo, Betania, Payne, Karen, Piper, Jo, Richardson, Sue, Rytina, Ed, Warren, Anne, Coker, Liz, Godsall, Gemma, Arends, Mark, O’Neill, Amanda, Rintoul, Katy, Goymer, Donna, Taylor, Julie, Matthews, Claire, Bhayani, Harshil, Osalador, Tina, Niwaz, Zakiya, Higgins, Anna, Bamsey, Olivia, Salter, Janine, Renouf, Louise, Noel-Storr, Glenn, Roberts, Helen, Gierejko, Kasia, Knapman, Paola, Wotherspoon, Andrew, Stamp, Gordon, Attygailye, Ayoma, Hazell, Steve, Osin, Peter, Nerurkar, Ash, Francis, Steven, Runde, Marion, Arch, Jo, Chitnis, Xavier, Siu, Bernard, Townsend, Debra, Hennelly, Laura, Taylor, Natalie, Johnson, Bernadette, Banerjee, Susie, Pyle, Lynda, Hamill, Monica, Gyertson, Jenny, George, Angela, Patel, Krishna, Pearce, Karla, Edmonds, Kim, Sarker, Sarah, Eeles, Rosalind, Bancroft, Liz, Thomas, Sarah, Kano, Yukie, Rowland, Lisa, Brooks, Karen, O’brien, Mary, Bhosle, Jaishree, Priest, Kathy, Ayite, Bee, Severn, Jo, Beedham, Helen, Lucas, Nicky, Tye, Kim, Lorentzos, Alison, Webb, Janine, Kerr, Sarah, Corestav, Lisa, Bottero, Diego, Jell, Laura, Thomas, Janet, Marriott, Cheryl, Rajah, Neil, Cole, Andy, Ly, Dieu, Taniere, Philippe, O’sullivan, Brendan, Swift, Clare, Hughes, Frances, Neil, Desley, Hanby, Andrew, Banks, Roz, Ajayi, Dolapo, Barclay, Alison, Bishop, Julia Newton, Beirne, Debbie, Bernard, Andrew, Berry, Maxine, Bentley, Jo, Bishop, Tim, Chambers, Amy, Clarke, Jude, Crossley, Anne, Gahir, Narinder, Gibson, Debbie, Good, Rona, Grosios, Konstantina, Harnden, Pat, Hasler, Kate, Hindmarch, Damien, Jackson, Sharon, Johnstone, Colin, Jones, Anne-marie, Lambert, Gil, Lane, Sally, Mcnicholas, Nicola, Millican-Slater, Rebecca, Moriaty, Cath, Newsham, Alex, O’connell, Kara, Ripley, Lisa, Sebag-Montefiore, David, Simpson, Mary, Speirs, Val, Sugden, Joh, Tate, Lauren, Tidswell, Emma, Twelves, Chris, Walker, Christy, Waterhouse, Barry, Waugh, Martin, White, Louise, Wright, Elizabeth, Rogan, Jane, Ashton, Garry, Abbey, Caron, Greenhalgh, Michelle, Nonaka, Daisuke, Shing, Elwyn, Gibbard, Carmen, Burton, Georgina, Fawkes, Naomi, Marsden, Angela, Waddington, Rachael, Harrison, Phil, Moghadam, Shahrzad, Murray, Kate, Brown, Sarah, Mitchinson, Christy, Booton, Richard, Shah, Rajesh, Harrison, David, Oniscu, Anca, Wallace, William, Rae, Frances, Marshall, Craig, Mcleod, Linda, Charles, Morag, Sutherland, Sarah Jane, Dawson, Carol, Mitchell, Paul, Maclellan, Alex, Muir, Sandra, Johnstone, Lynne, O’connor, John, Johnstone, Shirley, Mcpherson, Jim, Hair, Jane, Pignatelli, Massimo, Armstrong, Roma, Oien, Karin, Evans, Jeff, Burgoyne, Margaret, Blessing, Karen, Duthie, Fraser, Moyes, Colin, Mallon, Elizabeth, Millan, David, Roberts, Fiona, Seywright, Morag, Fraser, Siobhan, Ford, Ian, Kean, Sharon, Flood, Marion, Grant, David, Mcdonald, Claire, Moffat, Tom, Mclelland, Hugh, Kyle, Alistair, Cameron, Graham, Wright, Martin, Kenny, Stephen, Mcauslan, Karen, Jones, Andrew, Fitzsimons, Ted, Graham, Fiona, Bell, Alexandra, Duffy, Phil, Fisher, Alec, Smith, Alexis, Shannon, Elaine, Woods, Bryan, Hutchison, Colin, Booth, Angela, Duffy, Lyndsay, Mcculloch, Gillian, Sadiq, Hudda, Deakin, Susan, Haywood, Steven, Mason, Malcolm, Chester, John, Parry-jones, Alison, Macarthur, Abby, Williams, Suzanne, Griffiths, David, Morgan, Fiona, and Bailey, Hazel

Published
2018
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32. Relapses in early‐stage follicular lymphoma frequently develop via a divergent evolution from their clonally related precursor cells.

Author

Makker, Jasmine, Wotherspoon, Andrew, Tzioni, Maria‐Myrsini, Chen, Zi, Guo, Sarah, Jiang, Dan, Casa, Calogero, Cucco, Francesco, and Du, Ming‐Qing

Subjects
FOLLICULAR lymphoma, DISEASE relapse, NUCLEOTIDE sequencing, CANCER relapse, LYMPHOMAS, PERIODICAL publishing
Abstract

Follicular lymphoma (FL) develops through a stepwise acquisition of cooperative genetic changes with t(14;18)(q32;q21)/IGH::BCL2 occurring early at the pre‐B stage of B‐cell development. Patients with FL typically show an indolent clinical course, remitting and relapsing with the eventual development of resistance to treatments. Interestingly, the majority of transformed FL do not progress directly from FL but originate from their clonally related lymphoma precursor (CLP) cells. To examine whether such divergent tumour evolution also underpins the relapses in patients with early‐stage FL, we investigated by targeted next‐generation sequencing 13 cases (stage I = 9, stage II = 4), who showed complete remission (mean: 5 years; range: 1–11.5 years) following local radiotherapy but subsequently relapsed (≥2 in 5). A clonal relationship between the diagnostic FL and relapses was confirmed in 11 cases. In six cases, common and distinct variants were seen between the paired diagnostic and relapsed lymphomas, indicating their divergent evolution from a CLP. In two cases, different B‐cell clones were involved in the diagnostic and relapsed lymphomas, including one case involving two different BCL2 translocations. In the remaining five cases, the relapsed lymphoma developed via a linear progression (n = 4) or a mixed evolutionary path (n = 1). These findings may bear important implications in the routine diagnosis and management of relapsed FL. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Corrigendum to “Epstein–Barr-virus-positive large B-cell lymphoma associated with breast implants: an analysis of eight patients suggesting a possible pathogenetic relationship.” [Modern Pathology 34 (2021) 2154–2167]

Author

Medeiros, L. Jeffrey, Marques-Piubelli, Mario L., Sangiorgio, Valentina F.I., Ruiz-Cordero, Roberto, Vega, Francisco, Feldman, Andrew L., Chapman, Jennifer R., Clemens, Mark W., Hunt, Kelly K., Evans, Mark G., Khoo, Christine, Lade, Stephen, Silberman, Mark, Morkowski, Jerzy, Pina, Edward M., Mills, Daniel C., Bates, Christopher M., Magno, Winston B., Sohani, Aliyah R., Sieling, Beth A., O’Donoghue, Joseph M., Bacon, Chris M., Patani, Neill, Televantou, Despina, Turner, Suzanne D., Johnson, Laura, MacNeill, Fiona, Wotherspoon, Andrew C., Iyer, Swaminathan P., Malpica, Luis E., Patel, Keyur P., Xu, Jie, and Miranda, Roberto N.

Published
2023
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37. Guideline for the diagnosis and management of marginal zone lymphomas: A British Society of Haematology Guideline.

Author

Walewska, Renata, Eyre, Toby A., Barrington, Sally, Brady, Jessica, Fields, Paul, Iyengar, Sunil, Joshi, Anurag, Menne, Tobias, Parry‐Jones, Nilima, Walter, Harriet, Wotherspoon, Andrew, and Linton, Kim

Subjects
HELICOBACTER pylori infections, HEPATITIS C, HEMATOLOGY, MUCOSA-associated lymphoid tissue lymphoma, DIFFUSE large B-cell lymphomas, LYMPHOMAS, HODGKIN'S disease
Abstract

This document is a guideline published in the British Journal of Haematology that provides healthcare professionals with clear guidance on the diagnosis and management of patients with marginal zone lymphoma (MZL). MZL is a group of clinically indolent mature B-cell lymphomas that arise from memory B cells in the marginal zones of secondary lymphoid tissues. The guideline discusses the different subtypes of MZL, diagnostic methods, and potential aetiological factors. It also includes information on treatment options for different stages of MZL, including radiotherapy, systemic therapy, and targeted agents. The document emphasizes the importance of individualized patient care and shared decision making. [Extracted from the article]

Published
2024
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45. Oncological Outcomes After Multidisciplinary Management of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL).

Author

O'Connell, Rachel L., Sharma, Bhupinder, El-Sharkawi, Dima, Wotherspoon, Andrew, Attygalle, Ayoma D., MacNeill, Fiona, Khan, Aadil A., and Tasoulis, Marios-Konstantinos

Abstract

Introduction: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon type of non-Hodgkin lymphoma, associated with breast implant capsules. Despite improvements in our understanding of BIA-ALCL, communicating the prognosis to patients remains challenging due to limited long-term follow-up data. This has important implications for decision-making, including recommendations for subsequent reconstructive procedures. The aim of this study was to assess the longer-term oncological outcomes of patients receiving multidisciplinary treatment for BIA-ALCL. Methods: This was a retrospective cohort study of BIA-ALCL patients treated at a tertiary referral unit. The data are presented using simple descriptive statistics. Results: Between 2015 and 2022, 18 BIA-ALCL patients were treated at our institution. The median age at diagnosis was 48.5 (IQR 41–55) years. Ten patients developed BIA-ALCL after cosmetic breast augmentation, and 8 after breast reconstruction following mastectomy for cancer. All patients had a history of textured implant insertion. The median time from first implant surgery to diagnosis was 8.5 (IQR 7–12) years. All patients underwent en-bloc total capsulectomy with implant removal, and 2 received systemic therapy. Fifteen patients had Stage I (IA–IC) disease, 2 had Stage IIA and 1 Stage III BIA-ALCL, based on the TNM classification system. At a median follow-up of 45 (IQR 15–71) months, there were no episodes of local or systemic relapse or death. Conclusions: Surgical management for BIA-ALCL is sufficient in early-stage disease, and associated with excellent oncological outcomes. This information is reassuring for patients when discussing recurrence risk. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Divergent evolution of metachronous follicular lymphoma and extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue from a common precursor.

Author

Tzioni, Maria‐Myrsini, Wotherspoon, Andrew, Chen, Zi, Cucco, Francesco, Makker, Jasmine, and Du, Ming‐Qing

Subjects
MUCOSA-associated lymphoid tissue lymphoma, FOLLICULAR lymphoma, HODGKIN'S disease, IMMUNOGLOBULIN genes, LYMPHOMAS, MANTLE cell lymphoma
Abstract

The translocation t(14;18)(q32:q21)/IGH::BCL2 occurs at the pre‐B stage of B‐cell development in the bone marrow and is insufficient for malignant transformation, although it leads to the formation of in situ follicular B‐cell neoplasia (ISFN). Despite that, the translocation is the genetic hallmark of follicular lymphoma (FL), it occurs infrequently in metachronous/synchronous lymphomas, including extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (EMZL), mantle cell lymphoma, and Hodgkin's lymphoma. In each of these scenarios, the two lymphomas often appear to be clonally related by analyses of IGH::BCL2 and/or rearranged IG genes. However, it remains largely unknown whether one lymphoma originates from the other or they develop independently. We studied five cases of metachronous EMZL and FL. In four cases, the two lymphomas were clonally related, as shown by identical IGH::BCL2 and/or rearranged IG genes or shared mutations. There were common and unique mutations between the paired EMZL and FL, indicating that they developed independently from a common premalignant cell population, harbouring IGH::BCL2 in three cases. Furthermore, case 1 presented with three metachronous FLs, and all of them originated from a common precursor cell population via divergent evolution. Our findings highlight the multi‐malignant potential of IGH::BCL2‐positive B‐cells. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases

Author

Frentzas, Sophia, Simoneau, Eve, Bridgeman, Victoria L, Vermeulen, Peter B, Foo, Shane, Kostaras, Eleftherios, Nathan, Mark R, Wotherspoon, Andrew, Gao, Zu-hua, Shi, Yu, Van den Eynden, Gert, Daley, Frances, Peckitt, Clare, Tan, Xianming, Salman, Ayat, Lazaris, Anthoula, Gazinska, Patrycja, Berg, Tracy J, Eltahir, Zak, Ritsma, Laila, van Rheenen, Jacco, Khashper, Alla, Brown, Gina, Nyström, Hanna, Sund, Malin, Van Laere, Steven, Loyer, Evelyne, Dirix, Luc, Cunningham, David, Metrakos, Peter, and Reynolds, Andrew R

Subjects
Angiogenesis inhibitors -- Patient outcomes, Liver cancer -- Drug therapy, Cancer metastasis -- Drug therapy, Biological sciences, Health
Abstract

The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the nonangiogenic mechanism of vessel co-option. Here we show that vessel co-option is associated with a poor response to the anti-angiogenic agent bevacizumab in patients with colorectal cancer liver metastases. Moreover, we find that vessel co-option is also prevalent in human breast cancer liver metastases, a setting in which results with anti-angiogenic therapy have been disappointing. In preclinical mechanistic studies, we found that cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo and that, in this setting, combined inhibition of angiogenesis and vessel co-option is more effective than the inhibition of angiogenesis alone. Vessel co-option is therefore a clinically relevant mechanism of resistance to anti-angiogenic therapy and combined inhibition of angiogenesis and vessel co-option might be a warranted therapeutic strategy., Author(s): Sophia Frentzas [1, 2]; Eve Simoneau [3]; Victoria L Bridgeman [1]; Peter B Vermeulen [1, 4]; Shane Foo [1]; Eleftherios Kostaras [1]; Mark R Nathan [1]; Andrew Wotherspoon [2]; [...]

Published
2016
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50. ESMO Guidelines consensus conference on malignant lymphoma 2011 part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL)

Author

Agostinelli, Claudio, Arcaini, Luca, Caligaris-Cappio, Federico, Campo, Elias, Coiffier, Bertrand, Corradini, Paolo, D'Amore, Francesco, Dreger, Peter, Dreyling, Martin, Federico, Massimo, Gallamini, Andrea, Gaulard, Philippe, Geisler, Christian H., Ghielmini, Michele, Gisselbrecht, Christian, da Silva, Maria Gomes, Gribben, John, Hermine, Olivier, Hoskin, Peter, Iannitto, Emilio, Kim, Won Seog, Kimby, Eva, Kluin-Nelemans, Hanneke C., Koch, Peter, Ladetto, Marco, Le Gouill, Steven, Lopez-Guillermo, Armando, Marcus, Robert, McNamara, Christopher, Montalban, Carlos, Montoto, Silvia, Montserrat, Emili, Pfreundschuh, Michael, Raderer, Markus, Rodriguez, José, Salles, Gilles, Bernard, Claude, Schmitz, Norbert, Shpilberg, Ofer, Stilgenbauer, Stephan, Thieblemont, Catherine, Tilly, Hervé, Tournilhac, Olivier, Trümper, Lorenz, Vitolo, Umberto, Walewski, Jan, Wotherspoon, Andrew, Zucca, Emanuele, Ghielmini, M., Vitolo, U., Kimby, E., Montoto, S., Walewski, J., Pfreundschuh, M., Federico, M., Hoskin, P., McNamara, C., Caligaris-Cappio, F., Stilgenbauer, S., Marcus, R., Trneny, M., Dreger, P., Montserrat, E., and Dreyling, M.

Published
2013
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