Search

Oestrogen is known to be strongly associated with ovarian cancer. There was much work to show the importance of lncRNA SNHG17 in ovarian cancer. However, no study has revealed the molecular regulatory mechanism and functional effects between oestrogen and SNHG17 in the development and metastasis of ovarian cancer. In this study, we found that SNHG17 expression was significantly increased in ovarian cancer and positively correlated with oestrogen treatment. Oestrogen could promote M2 macrophage polarization as well as ovarian cancer cells SKOV3 and ES2 cell exosomal SNHG17 expression. When exposure to oestrogen, exosomal SNHG17 promoted ovarian cancer cell proliferation, migration, invasion and epithelial‐mesenchymal transition (EMT) in vitro, and tumour growth and lung metastasis in vivo by accelerating M2‐like phenotype of macrophages. Mechanically, exosomal SNHG17 could facilitate the release of CCL13 from M2 macrophage via the PI3K‐Akt signalling pathway. Moreover, CCL13‐CCR2 axis was identified to be involved in ovarian cancer tumour behaviours driven by oestrogen. There results demonstrate a novel mechanism that exosomal SNHG17 exerts an oncogenic effect on ovarian cancer via the CCL13–CCR2–M2 macrophage axis upon oestrogen treatment, of which SNHG17 may be a potential biomarker and therapeutic target for ovarian cancer responded to oestrogen. [ABSTRACT FROM AUTHOR]

MoCoB‐based cermets have been regarded as the potential substitution of WC cermets with high hardness, high melting point and high oxidation resistance. Ternary borides‐based cermets are widely used in extreme environment, such as high‐pressure environment. Therefore, it is significant to explore the mechanical properties and electronic structures of transition elements X (X = V, Mn, Fe, Ni) atoms doped MoCoB under high pressure, which are performed by first‐principles calculations to provide guidance for industry applications. The analysis of cohesive energy and formation enthalpy indicates high pressure leads to unstable states with lower lattice constants and crystal volumes. The deviation of cohesive energy and formation enthalpy indicate Mo4Co3FeB4 and Mo4Co3NiB4 have similar stability. The shear modulus, Young's modulus and bulk modulus increase under high pressure, which consists with the increasing of covalence. The variation of ductility and anisotropy indicate similar upward trend, which is verified by Poisson's ratio, B/G ratio and anisotropy index AU. The analysis of overlap population indicates high pressure leads to the increasing of covalence of B‐Co covalent bonds and the decreasing of the covalence of B‐Mo covalent bonds. The analysis of electronic structures indicates the high pressure leads to higher hybridization and lower density of states of metallic bonds. The analysis of charge density difference consists with the variation of mechanical properties, implying shorter bond length and higher bonds strength under high pressure. [ABSTRACT FROM AUTHOR]