30 results on '"Yener, Haydar Murat"'
Search Results
2. The Association of Blood Type Differences and Signal-noise Ratio in TEOAE and DPAOE in Individuals with Normal Hearing.
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Kara, Eyyup, Deniz, Burcu, Kara, Halide Çetin, Çankaya, Sare, Çakan, Doğan, and Yener, Haydar Murat
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BLOOD groups ,SIGNAL-to-noise ratio ,OTOACOUSTIC emissions - Abstract
Objective: The aim of this study was to investigate whether ABO and Rhesus (Rh) blood type systems are associated with distortion product otoacoustic emission (DPOAE) and transient otoacoustic emission (TEOAE) amplitudes, with the hypothesis that blood types affect hearing thresholds. Methods: Seventy participants with normal hearing, aged 18-26 years, with normal tympanometry and otoscopic examination findings, were included in the study. TEOAE and DPOAE tests were conducted on all participants. Results: The Rh factor did not significantly affect the OAE results. It was found that the TEOAE amplitudes of blood type B at 1.4 kHz in the left ear were higher than those of blood types A and AB. The amplitude of AB blood was lower than that of O, A, and B blood types at 2 kHz. Conclusion: Our study results did not indicate a consistent pattern for a specific blood type, in contrast to previous findings. Additional research is required to investigate the potential correlation between hearing function and ABO and Rh blood types. [ABSTRACT FROM AUTHOR]
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- 2024
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3. The impact of the tumor immune microenvironment and tumor-infiltrating lymphocyte subgroups on laryngeal cancer prognosis.
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Tevetoğlu, Fırat, Çomunoğlu, Nil, and Yener, Haydar Murat
- Abstract
The absence of improvement in survival rates across various cancers, including laryngeal cancer, has led to an increasing interest in understanding the immune response to cancer. In head and neck cancers, immune modulatory mechanisms such as immune microenvironment and immune infiltration are important in cancer pathogenesis. This study aims to explore the distribution of tumor-infiltrating lymphocyte (TIL) subgroups in the immune microenvironment and evaluate their impact on tumor histopathological characteristics and prognosis. The study included 50 patients who underwent laryngectomy for laryngeal squamous cell carcinoma, in Istanbul University - Cerrahpaşa, Faculty of Medicine Department of Otorhinolaryngology, between January 2016 and January 2018. Pathology specimens were evaluated using immunohistochemistry to assess the expressions of the CD3, CD20, CD8, CD4, CD25, and FoxP3 markers, identifying subgroups of TILs. The investigation aimed to uncover how these subgroups influence tumor histopathological features and survival outcomes. The high infiltration of CD3, CD20, and CD4 had a positive impact on disease-specific survival, disease-free survival, and recurrence-free survival. In addition, overall survival was positively affected by high CD3 and CD4 infiltrations. However, no significant relationship was observed between the expressions of CD8, FoxP3, and CD25 and any of the survival parameters. The infiltration of CD3, CD20, and CD4 positive cells indicative of a robust antitumoral immune response—emerged as favorable prognostic factors in laryngeal cancer. These findings suggest that enhancing the infiltration of CD3, CD20, and CD4 lymphocytes could be a therapeutic strategy worth exploring in clinical trials. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Dilated Minute Chambers in Laryngeal Vocal Fold Polyps: Histopathological and Ultrastructural Features
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Comunoglu, Nil, Kocak, Ismail, Saygi, Halil Ibrahim, Yener, Haydar Murat, Batur, Sebnem, Demiray, Sirin Bakti, Seckin, Ismail, Tanriover, Ozlem, and Comunoglu, Cem
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- 2020
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5. Effect of Nasal Soft-Tissue Envelope Thickness on Postoperative Healing Process Following Rhinoplasty
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Erdur, Zülküf Burak, Öktem, Fatih, Inci, Ender, Yener, Haydar Murat, and Üstündağ, Ahmet
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- 2021
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6. Does Anterior Commissure Involvement Change the Selection of Treatment Modality in Early-Stage Glottic Larynx Cancer?
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Dağdelen, Meltem, Yener, Haydar Murat, Hekim, Muhammed Veysel, Şahin, Merve, Tevetoğlu, Fırat, Peker, Sinem Kara, Aliyeva, Chinara, Yılmaz, Yetkin Zeki, Gözen, Emine Deniz, Karaman, Emin, and Erol Uzel, Günay Can6,Ömer
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LARYNGEAL cancer , *LARYNX , *OVERALL survival , *MICROSURGERY , *SURVIVAL rate - Abstract
Objective: Glottic laryngeal cancers are detected at an early stage at the time of diagnosis. Radiotherapy or transoral laser microsurgery as a local treatment is a choice for early-stage glottic laryngeal cancer. This study aims to investigate the local control rate after radiotherapy or transoral laser microsurgery for early-stage glottic laryngeal cancer with anterior commissure involvement. Methods: In total, 119 patients with early-stage (Tis-T1-2) laryngeal cancer were treated in our institution with radiotherapy or transoral laser microsurgery between 2009 and 2021. The median follow-up time was 52 months. Seventy-three patients underwent transoral laser microsurgery. Forty-six patients received radiotherapy, and there were 41 patients with anterior commissure involvement. Results: The 2 and 5 years overall survival rates were 92% and 73%, whereas local failure-free survival rates were 84% and 82% in all groups, respectively. The 2-year overall survival was 88% in the radiotherapy arm and 94% in the transoral laser microsurgery arm, respectively. There was no statistically significant difference between the two treatment groups for overall survival (P: .062). According to anterior commissure involvement, 29 underwent transoral laser microsurgery, whereas 12 patients received radiotherapy. A total of 9 local failures occurred in the transoral laser microsurgery group, there was no recurrence in the radiotherapy group (P: 0.028). Conclusion: There was no statistically significant difference between the two treatment groups for local failure-free survival and overall survival. However, in the case of the anterior commissure involvement, 9 local failures occurred in the transoral laser microsurgery group, and there was no recurrence in the radiotherapy group. Radiotherapy might be recommended in early-stage glottic laryngeal cancer, especially in patients with anterior commissure involvement. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Role of Preoperative Embolization in Surgical Treatment of the Carotid Body Paragangliomas
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Inan, Hakki Caner, Yener, Haydar Murat, Karaman, Emin, Kizilkiliç, Osman, Cansiz, Harun, and Eker, Çağlar
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- 2019
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8. Effect of energy-based devices on voice quality after total thyroidectomy
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Uludag, Server Sezgin, Teksoz, Serkan, Arikan, Akif Enes, Tarhan, Ozge, Yener, Haydar Murat, Ozcan, Murat, Liddy, Whitney, and Randolph, Gregory William
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- 2017
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9. Osteosarcoma of the Ethmoid Sinus
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Erdur, Zülküf Burak, Gözen, Emine Deniz, Inan, Hakki Caner, Yener, Haydar Murat, Çomunoğlu, Nil, Yol, Cansu, Papila, Çiğdem, and Cansiz, Harun
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- 2018
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10. Cellular Angiofibroma of the Nasopharynx
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Erdur, Zülküf Burak, Yener, Haydar Murat, Yilmaz, Mehmet, Karaaltin, Ayşegül Batioğlu, Inan, Hakki Caner, Alaskarov, Elvin, and Gozen, Emine Deniz
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- 2017
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11. Cervical Necrotizing Fasciitis of Odontogenic Origin and Hyperbaric Oxygen Therapy
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Inan, Caner Hakki, Yener, Haydar Murat, Yilmaz, Mehmet, Gözen, Emine Deniz, Erdur, Zülküf Burak, Oroğlu, Bengüsu, Olcay, Eren, and Memmedova, Nermin
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- 2017
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12. Evaluation of Inflammatory Blood Markers in Sinonasal Inverted Papilloma.
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Erdur, Zülküf Burak, Özdoğan, Hasan Ahmet, Yener, Haydar Murat, Karaman, Emin, Cansız, Harun, Aliyeva, Çınare, Batur, Şebnem, and İnan, Hakkı Caner
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BIOMARKERS ,PLATELET lymphocyte ratio ,INFLAMMATION ,PAPILLOMA ,PARANASAL sinus cancer ,RETROSPECTIVE studies ,NEUTROPHIL lymphocyte ratio ,NASAL cavity ,DESCRIPTIVE statistics ,NASAL tumors ,LOGISTIC regression analysis ,MEAN platelet volume - Abstract
Objective: Sinonasal inverted papillomas are benign neoplasms of the nasal cavity and paranasal sinuses. They have characteristic features such as a high risk of recurrence and possible malignant transformation. This study was conducted to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers. Patients and Methods: Sixty-five patients who were diagnosed histologically as having sinonasal inverted papilloma and 65 age- and sex-matched healthy controls were included in the study. Inflammatory blood markers such as neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), red cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) of the patient and control groups were compared. Results: There were no statistically significant differences between the patients and controls for white blood cell, platelet, hemoglobin, neutrophil, and lymphocyte counts (P >.05). No statistically significant difference was found between the patients and controls for NLR, PLR, RDW, MPV, and PDW (P >.05). In the logistic regression analysis model, which was created to investigate the effects of inflammatory blood markers in determining the patient group, the increase in the NLR and decrease in the PLR were found to be statistically significant factors (P =.008, P =.039). Conclusion: This is the first study in the literature to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers, and the results suggest that NLR and PLR may be used to distinguish patients with sinonasal inverted papilloma from controls. [ABSTRACT FROM AUTHOR]
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- 2023
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13. The Role of Preemptive Infiltration Anesthesia in the Management of Postoperative Pain Following Septoplasty.
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Yener, Haydar Murat, Akiner, Umur, Sari, Elif, Erdur, Zülküf Burak, Tevetoğlu, Firat, and Gözen, Emine Deniz
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POSTOPERATIVE pain treatment , *LOCAL anesthesia , *NASAL septum , *ADMINISTRATION of anesthetics , *POSTOPERATIVE pain , *ANESTHESIA - Abstract
Introduction Septoplasty is one of the most common surgical procedures in rhinology practice. Two major problems encountered after septoplasty are pain and bleeding. Preoperative administration of analgesics before the surgical stimulus, which is the main concept of preemptive analgesia, decreases postoperative pain. Objective The present study was designed to investigate whether preincisional lidocaine infiltration to the subperichondrial area during septoplasty surgery reduced or not postoperative pain and analgesic use. Methods The present prospective, randomized, placebo controlled, double-blind trial was conducted on 64 consecutive patients with nasal septum deviation. Patients were randomly divided into 2 groups; the study group received 2% 20mg lidocaine/cc (n=31), and the control group received 6 cc 0.9% NaCl (n=33). A standard questionnaire was given to each patient to mark his or her pain score between 0 and 10 at the 1st, 3rd, 6th, 12th, and 24th hours. Results The mean and the range of visual analogue scale (VAS) scores of the patients in the study group at the 1st, 3rd, 12th, and 24thx hours were 4.03±3.08 (0-10); 3.42±2.39 (0-8); 2.97±2.22 (0-8); 2.87±2.61 (0-9); and 1.94±2.06 (0-9) respectively. The mean and the range of VAS scores of the patients in the control group at the 1st, 3rd, 12th, and 24th hours were 4.12±2.7 (0-10); 3.45±2.4 (0-10); 2.94±2.7 (0-10); 2.79±2.34 (0-10); and 1.5±1.8 (0-6), respectively. The statistical analysis revealed no significant difference among the groups. Conclusion The preemptive local anesthetic administration to the incision area and under the mucoperichondrial flap before septoplasty does not decrease the level of postoperative pain. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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14. The Effects of Different Frequency Lowering Technologies' Performances on Speech in Noise Test.
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Kara, Eyyüp, Şenkal, Özgül Akın, Kılıç, Mert, Kara, Halide Çetin, Çapar, Serpil Hülya, and Yener, Haydar Murat
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AUDITORY perception ,HEARING aids ,SPEECH perception ,NOISE ,SENSORINEURAL hearing loss - Abstract
Objective: Hearing instrument manufacturers have developed 3 different frequency lowering technologies, especially to compensate for the perceptual effects of high-frequency hearing loss. We aimed to compare the effects of 3 different frequency lowering methods. Methods: We assigned 132 participants who had bilateral, symmetrical, high-frequency sensorineural hearing loss into groups with hearing aids having frequency compression, frequency transposition, and frequency composition strategies. By hearing measurements, participants' hearing thresholds and speech discrimination/speech in noise scores with and without different frequency lowering technologies were obtained. Results: Hearing aids incorporated with frequency compression, frequency transposition, and frequency composition had significant speech discrimination benefits with similar outcomes (P < .05). Conclusion: Three different frequency lowering technologies had similar outcomes regarding speech discrimination and speech in noise improvements. It is better to use frequency lowering technologies to better speech discrimination/speech in noise scores in adults. [ABSTRACT FROM AUTHOR]
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- 2022
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15. The Effect of Diet on ECP, IL-4 and IL-31 in Patients with Persistent Allergic Rhinitis.
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Yılmaz, Yetkin Zeki, Yılmaz, Begüm Bahar, Yener, Haydar Murat, and Çanakçıoğlu, Salih
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ALLERGIES ,INTERLEUKIN-1 - Abstract
Objective: The aim of this study is to evaluate the effects of dietary changes on late phase of allergic reaction in patients with allergic rhinitis (AR) by measuring eosinophilic cationic protein (ECP), interleukin (IL)-4 and IL-31 levels. Methods: Sixty participants (40 patients with AR and 20 healthy control subjects) were included in this study. Forty patients with confirmed diagnosis of AR were randomly divided into two groups, all patients were prescribed the same treatment, intranasal azelastine hydrochloride. Patients in group 1 were asked to change their diet from Western to Mediterranean diet by eliminating processed meat, processed sugar, and polyunsaturated fatty acids. Blood samples of every subject were driven at the beginning and three months later to study ECP, IL-4 and IL- 31 levels. By using ELISA method IL-4 and IL-31 levels were determined and compared between healthy volunteers and patients. Results: There was a significant difference in terms of ECP levels in group 2. The posttreatment ECP levels were significantly higher than pretreatment levels in group 2 (p=0.025 and p<0.05). There was no significant difference in terms of other parameters. Conclusion: In our study, we showed that the laboratory parameters associated with AR were positively affected by the Mediterranean diet. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Is Preoperative Embolization Necessary for Carotid Paraganglioma Resection: Experience of a Tertiary Center.
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Gözen, Emine Deniz, Tevetoğlu, Fırat, Kara, Sinem, Kızılkılıç, Osman, and Yener, Haydar Murat
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CAROTID artery radiography ,PREVENTION of surgical complications ,CAROTID artery surgery ,PREOPERATIVE care ,SURGICAL blood loss ,HOSPITALS ,BLOOD vessels ,HEMATOCRIT ,CAROTID body ,CRANIAL nerves ,AGE distribution ,THERAPEUTIC embolization ,TERTIARY care ,RETROSPECTIVE studies ,ACQUISITION of data ,SURGERY ,PATIENTS ,MAGNETIC resonance imaging ,TREATMENT effectiveness ,VASCULAR surgery ,CANCER patients ,COMPARATIVE studies ,SEX distribution ,MEDICAL records ,PARAGANGLIOMA ,ANGIOGRAPHY ,EVALUATION - Abstract
Purpose: This study was designed to investigate whether preoperative embolization is a useful procedure to decrease blood loss and neurovascular complications for carotid body tumor (CBT) surgery or not. Methods: Medical records of our tertiary care center from 2012 to 2019 were scanned for patients who underwent surgery for CBT, retrospectively. Age, gender, complaint and head and neck examination findings at the time of presentation, preoperative complete blood count parameters, imaging records (cervical magnetic resonance imaging and carotid artery angiography), Shamblin classification, tumor size, intraoperative findings, and postoperative complications were noted. Results: A total of 26 patients were operated due to CBT between 2012 and 2019 in our clinic; preoperative arterial embolization was performed to 15 (57.7%) patients, and 11 (42.3%) patients were operated without embolization. Youngest patient was 24 years old, while oldest was 69 years and mean age was 44.35 ± 12.73. (embolization group: ages ranging between 24 and 64 with a mean of 41.5 ± 11.02 years; in nonembolization group: ages ranging between 26 and 69 with a mean of 48.1 ± 14.3). Embolization status was not significantly related to cranial nerve injury, vascular injury, overall complications, and hematocrit decrease. Arterial injury is more likely to occur with increasing Shamblin class (r =.39; P =.04). Tumor size is not found to be significantly related to cranial nerve injury, vascular injury, overall complications, and hematocrit decrease, but cranial nerve injury and vascular injury were more likely to occur in large tumors (r =.34; P =.089 and r =.34; P =.087, respectively). Age was significantly and negatively correlated to vascular injury (r = −.51; P =.05). Vascular injury was significantly correlated with gender (male predominance: r = −.64; P =.000). Conclusion: Although preoperative arterial embolization is considered to attenuate the complication risk, we found that there was no significant difference among the patients with or without embolization. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Electrically Evoked Auditory Late Responses as a Novel Method for Cochlear Implant Programming.
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Deniz, Risvan, Kara, Eyyup, Deniz, Burcu, Kara, Halide Cetin, Yener, Haydar Murat, Atas, Ahmet, Deniz, Rışvan, Kara, Halide Çetin, Ataş, Ahmet, and Deniz, Rişvan
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- 2022
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18. Diagnostic and Prognostic Value of M30 and M65 in Laryngeal Squamous Cell Carcinoma.
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Yılmaz, Yetkin Zeki, Yener, Haydar Murat, Akıner, Umur, Tarhan, Özge, Ekmekci, Hakan, Ekmekci, Özlem Balcı, Yılmaz, Mehmet, and Özdoğan, Hasan Ahmet
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SQUAMOUS cell carcinoma , *LARYNGEAL cancer , *LYMPHATIC metastasis - Abstract
Objective: This study aimed to investigate the preoperative and postoperative plasma M30 and M65 levels in laryngeal squamous cell carcinoma (LSCC) and its relationship with the prognostic value, clinical stage, histological differentiation, and lymph node metastasis. Methods: This study was prospectively conducted, which included 29 patients with LSCC (group 1) and 19 healthy individuals (group 2). The venous blood was collected from all patients in the preoperative and first postoperative months. Serum M30 and M65 levels were determined by enzymelinked immunosorbent assay. Results: A statistically significant difference was found in serum M30 levels between groups 1 and 2. (Median: 233.94 U/L vs. 95.17 U/L) (p=0.001), whereas no significant difference was found in serum M65 values in groups 1 and 2 (median: 350.67 U/L vs. 309.94 U/L) (p<0.387). Conclusion: The preoperative and postoperative serum M30 and M65 levels in the patients with laryngeal carcinoma were evaluated, which evaluated M30 levels were high not only in advanced-stage tumors but also in early staged tumors. Thus, following the M30 level may be useful for the early diagnosis of laryngeal cancers. [ABSTRACT FROM AUTHOR]
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- 2021
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19. Measuring Physical Activity in Children With Cochlear Implants Using Self-Reported PAQ-C Before and During the COVID-19 Pandemic.
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Akin Senkal, Ozgul, Kara, Eyyup, Senkal, Ozan, and Yener, Haydar Murat
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- 2021
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20. INVESTIGATION OF SALIVARY miR-9, miR-34a ve miR-196a LEVELS IN FANCONI ANEMIA AND ORAL SQUAMOUS CELL CARCINOMA PATIENTS
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Kilic, Zisan Asal, Yalman, Nevin, Celkan, Tulin Tiraje, Basaran, Bora, Yener, Haydar Murat, Dasdemir, Selcuk, and Günver, Mehmet Güven
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- 2021
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21. Baş-Boyun Kanseri Olan Hastalarda Geleneksel ve Tamamlayıcı Tedavi Kullanımının Araştırılması.
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İNAN, Hakkı Caner, KUZU, Şehri Burcu, and YENER, Haydar Murat
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HEAD & neck cancer treatment ,SOCIODEMOGRAPHIC factors ,STATISTICAL software ,PHYTOTHERAPY ,CLINICAL trials - Abstract
Copyright of Journal of Traditional Medical Complementary Therapies is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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22. Erken Evre Glottik Larinks Kanserinde Anterior Komissur Tutulumu Tedavi Modalitesini Değiştirir Mi?
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Dağdelen, Meltem, Hekim, Veysel Muhammed, Yener, Haydar Murat, Şahin, Merve, Tevetoğlu, Fırat, Peker, Sinem Kara, Aliyeva, Chinara, Yılmaz, Yetkin Zeki, Gözen, Emine Deniz, Karaman, Emin, Can, Günay, and Uzel, Ömer Erol
- Abstract
Copyright of Turkish Journal of Oncology / Türk Onkoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
23. Extra-Cochlear Insertion in Cochlear Implantation: A Potentially Disastrous Condition.
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Deniz Gözen, Emine, Tevetoğlu, Fırat, Yener, Haydar Murat, Kara, Eyüp, Ataş, Ahmet, Şirolu, Sabri, Kızılkılıç, Osman, Cansız, Harun, and Karaman, Emin
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INTERNAL carotid artery , *SURGICAL complications , *SEMICIRCULAR canals , *REOPERATION - Abstract
OBJECTIVES: Cochlear implantation is an increasingly used technique for auditory rehabilitation of pediatric and adult population. Safe implantation is achieved in most cases; however, intraoperative complications and misplacement of the electrode are observed in some. The aim of this presentation was to review the characteristics of patients with extra-cochlear electrode insertion, postoperative diagnostic methods, and considerations in revision surgery. MATERIALS and METHODS: In total, 423 cases of cochlear implantation performed in our clinic between 2012 and 2018 were retrospectively analyzed and those of extra-cochlear implantation were evaluated. RESULTS: Extra-cochlear insertion was found in 3 patients. The electrode was placed into the internal acoustic canal in the first case, superior semicircular canal in the second case, and internal carotid artery canal in the third case. Cochlear insertion was achieved in all cases with re-implantation, and no complication was observed. CONCLUSION: This case series highlights that rare, but potentially serious, consequences of misplacement of the electrode in cochlear implantation can be successfully avoided and treated via a multidisciplinary approach. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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24. Inflammatory Myofibroblastic Tumor of the Parotid Gland.
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Kilic, Erkan, Ibrahimov, Metin, Aslan, Mehmet, Yener, Haydar Murat, and Karaman, Emin
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- 2012
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25. THE RELATIONSHIP BETWEEN DIX -- HALLPIKE OR ROLL TEST AND HEAD IMPULSE TEST.
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Ceylan, Didem Şahin, Ertürk, Pınar, Kara, Halide Çetin, Kara, Eyüp, Ceylan, Ahmet, and Yener, Haydar Murat
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SEMICIRCULAR canal physiology , *BENIGN paroxysmal positional vertigo , *VERTIGO , *VESTIBULAR nerve , *MEDICAL hospitals , *PHYSIOLOGY , *DIAGNOSIS , *PATIENTS - Abstract
INTRODUCTION: Dix-Hallpike and roll test are two of the positional tests that provide information about posterior, anterior and lateral semicircular canals, especially when applied to patients with suspected benign paroxysmal positional vertigo (BPPV). Video head impulse test (vHIT) is a useful test gives information about vertical and horizontal canals, vestibular nucleus and vestibular nerve in both ears. This study was conducted to assess the relationship between Dix -- Hallpike/Roll Test and vHIT. MATERIALS and METHODS: 76 patients (47 female, 29 male) who was referred with a diagnosis of BPPV to Istanbul University Cerrahpasa Medical Faculty Hospital to Audiology Department and whose age between 21 and 57 has evaluated. All patients were evaluated with Dix-Hallpike/Roll Test and vHIT tests and results were compared. RESULTS: Acording to Dix-Hallpike/Roll test results, it was found posterior canal BPPV in 55, lateral canal 18 patients and anterior canal BPPV in 6 patients. Results will be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2015
26. Evaluation of Inflammatory Blood Markers in Sinonasal Inverted Papilloma.
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Erdur ZB, Özdoğan HA, Yener HM, Karaman E, Cansız H, Aliyeva Ç, Batur Ş, and İnan HC
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- Humans, Biomarkers, Mean Platelet Volume, Erythrocyte Indices, Lymphocytes, Retrospective Studies, Papilloma, Inverted, Head and Neck Neoplasms, Respiratory Tract Neoplasms
- Abstract
Objective: Sinonasal inverted papillomas are benign neoplasms of the nasal cavity and paranasal sinuses. They have characteristic features such as a high risk of recurrence and possible malignant transformation. This study was conducted to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers., Patients and Methods: Sixty-five patients who were diagnosed histologically as having sinonasal inverted papilloma and 65 age- and sex-matched healthy controls were included in the study. Inflammatory blood markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), red cell distribution width (RDW), mean platelet volume (MPV), and platelet distribution width (PDW) of the patient and control groups were compared., Results: There were no statistically significant differences between the patients and controls for white blood cell, platelet, hemoglobin, neutrophil, and lymphocyte counts ( P > .05). No statistically significant difference was found between the patients and controls for NLR, PLR, RDW, MPV, and PDW ( P > .05). In the logistic regression analysis model, which was created to investigate the effects of inflammatory blood markers in determining the patient group, the increase in the NLR and decrease in the PLR were found to be statistically significant factors ( P = .008, P = .039)., Conclusion: This is the first study in the literature to investigate the relationship between sinonasal inverted papilloma and inflammatory blood markers, and the results suggest that NLR and PLR may be used to distinguish patients with sinonasal inverted papilloma from controls.
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- 2023
- Full Text
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27. Is Preoperative Embolization Necessary for Carotid Paraganglioma Resection: Experience of a Tertiary Center.
- Author
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Gözen ED, Tevetoğlu F, Kara S, Kızılkılıç O, and Yener HM
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- Adult, Angiography, Female, Humans, Male, Middle Aged, Preoperative Care methods, Retrospective Studies, Treatment Outcome, Young Adult, Carotid Body Tumor pathology, Carotid Body Tumor surgery, Cranial Nerve Injuries complications, Embolization, Therapeutic adverse effects, Embolization, Therapeutic methods, Vascular System Injuries complications
- Abstract
Purpose: This study was designed to investigate whether preoperative embolization is a useful procedure to decrease blood loss and neurovascular complications for carotid body tumor (CBT) surgery or not., Methods: Medical records of our tertiary care center from 2012 to 2019 were scanned for patients who underwent surgery for CBT, retrospectively. Age, gender, complaint and head and neck examination findings at the time of presentation, preoperative complete blood count parameters, imaging records (cervical magnetic resonance imaging and carotid artery angiography), Shamblin classification, tumor size, intraoperative findings, and postoperative complications were noted., Results: A total of 26 patients were operated due to CBT between 2012 and 2019 in our clinic; preoperative arterial embolization was performed to 15 (57.7%) patients, and 11 (42.3%) patients were operated without embolization. Youngest patient was 24 years old, while oldest was 69 years and mean age was 44.35 ± 12.73. (embolization group: ages ranging between 24 and 64 with a mean of 41.5 ± 11.02 years; in nonembolization group: ages ranging between 26 and 69 with a mean of 48.1 ± 14.3). Embolization status was not significantly related to cranial nerve injury, vascular injury, overall complications, and hematocrit decrease. Arterial injury is more likely to occur with increasing Shamblin class ( r = .39; P = .04). Tumor size is not found to be significantly related to cranial nerve injury, vascular injury, overall complications, and hematocrit decrease, but cranial nerve injury and vascular injury were more likely to occur in large tumors ( r = .34; P = .089 and r = .34; P = .087, respectively). Age was significantly and negatively correlated to vascular injury ( r = -.51; P = .05). Vascular injury was significantly correlated with gender (male predominance: r = -.64; P = .000)., Conclusion: Although preoperative arterial embolization is considered to attenuate the complication risk, we found that there was no significant difference among the patients with or without embolization.
- Published
- 2022
- Full Text
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28. Comparison of Tumor Infiltrating Lymphocyte Density with Histopathological Parameters and Effect on Prognosis in Head and Neck Squamous Cell Cancers.
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Sari E, Tokat T, Tarhan O, Dag H, Yilmaz YZ, and Yener HM
- Abstract
Objectives: The study aims to determine the ratio of the tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment in squamous cell carcinoma of head and neck and its effect on prognosis using histopathological parameters., Methods: The patients who underwent head and neck surgery with the diagnosis of squamous cell carcinoma of head and neck at Cerrahpaşa medical faculty ENT Clinic between January 2010 and November 2013 were included in this study. The age, gender, smoking status, alcohol use, radiologic images, and operation technique were analyzed for all patients. TNM pathologic staging, histologic differentiation grade, desmoplastic stromal reaction, vascular and perineural invasion, and lymph node metastasis were also evaluated. Representative hematoxylin-eosin stained slides from each block were cut and the ratio of tumor-infiltrating lymphocytes in tumor tissue was examined by an expert to confirm histology., Results: In this study, 114 patients (105 males and 9 females) met inclusion criteria and were included. The mean age was 60.3±9.7 (ranging from 27 to 85 years). TIL and desmoplastic stromal reaction were compared statistically to the extent of primary tumor, vascular and perineural invasion, lymph node metastasis and histological grade of the tumor. While there was no statistically significant difference between TIL and these parameters, there was a statistically significant correlation between desmoplastic stromal reaction and these parameters. Considering five years of patient survival, although TIL had a positive impact on the prognosis of the tumor, there was no statistically significant difference., Conclusion: We suggest that besides TNM pathologic staging and histologic parameters, immune cells reacting to the tumor will be a distinctive factor in determining the prognosis and new treatment methods. We believe that TIL will affect the current cancer treatments by increasing its anti-tumor effects and will give promising results in cancer immunotherapy., Competing Interests: Conflict of Interest: None declared., (Copyright: © 2020 by The Medical Bulletin of Sisli Etfal Hospital.)
- Published
- 2020
- Full Text
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29. The Efficacy of Intratympanic Steroid Injection in Tinnitus Cases Unresponsive to Medical Treatment.
- Author
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Yener HM, Sarı E, Aslan M, Yollu U, Gözen ED, and İnci E
- Subjects
- Adult, Aged, Audiometry, Female, Humans, Injection, Intratympanic, Male, Middle Aged, Prospective Studies, Tinnitus physiopathology, Treatment Outcome, Young Adult, Dexamethasone administration & dosage, Glucocorticoids administration & dosage, Severity of Illness Index, Tinnitus drug therapy
- Abstract
Objectives: To examine the efficacy of an intratympanic steroid injection in tinnitus cases unresponsive to medical treatment., Materials and Methods: The study was carried out at the Ear, Nose, and Throat Department with 107 patients (46 male, 61 female) between the ages of 20 and 77 with a mean of 42.8 years who had idiopathic tinnitus. Patients were randomized by simple randomization to receive intratympanic dexamethasone or isotonic solution. The patients received six intratympanic injections, two per week for three weeks. Tinnitus handicap index (THI) was performed before treatment and at first week, first month, and six months after the completion of the study protocol. The audiometric tests were performed six months after the treatment., Result: In the study group, pretreatment THI and post-treatment first month THI scores and pretreatment THI and post-treatment sixth month THI scores were significantly different whereas the same scores were not significantly different in the control group. The comparison of THI scores between the groups revealed significantly lower scores in the first and sixth months for the study group., Conclusion: The effect of the intratympanic injection of dexamethasone on the efficacy of treatment of tinnitus severity was statistically significant.
- Published
- 2020
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- View/download PDF
30. Extra-Cochlear Insertion in Cochlear Implantation: A Potentially Disastrous Condition.
- Author
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Gözen ED, Tevetoğlu F, Yener HM, Kara E, Ataş A, Şirolu S, Kızılkılıç O, Cansız H, and Karaman E
- Subjects
- Child, Preschool, Cochlea surgery, Female, Humans, Infant, Male, Retrospective Studies, Cochlear Implantation adverse effects, Cochlear Implants adverse effects, Electrodes, Implanted adverse effects, Hearing Loss, Sensorineural surgery, Reoperation methods
- Abstract
Objectives: Cochlear implantation is an increasingly used technique for auditory rehabilitation of pediatric and adult population. Safe implantation is achieved in most cases; however, intraoperative complications and misplacement of the electrode are observed in some. The aim of this presentation was to review the characteristics of patients with extra-cochlear electrode insertion, postoperative diagnostic methods, and considerations in revision surgery., Materials and Methods: In total, 423 cases of cochlear implantation performed in our clinic between 2012 and 2018 were retrospectively analyzed and those of extra-cochlear implantation were evaluated., Results: Extra-cochlear insertion was found in 3 patients. The electrode was placed into the internal acoustic canal in the first case, superior semicircular canal in the second case, and internal carotid artery canal in the third case. Cochlear insertion was achieved in all cases with re-implantation, and no complication was observed., Conclusion: This case series highlights that rare, but potentially serious, consequences of misplacement of the electrode in cochlear implantation can be successfully avoided and treated via a multidisciplinary approach.
- Published
- 2019
- Full Text
- View/download PDF
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