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Your search keyword '"Zhu, Xiao-Dong"' showing total 836 results
Start Over Author "Zhu, Xiao-Dong" Publication Type Academic Journals
836 results on '"Zhu, Xiao-Dong"'

6. Radiographic and α-fetoprotein response predict pathologic complete response to immunotherapy plus a TKI in hepatocellular carcinoma: a multicenter study

Author

Huang, Cheng, Zhu, Xiao-Dong, Shen, Ying-Hao, Xu, Bin, Wu, Dong, Ji, Yuan, Chen, Ling-Li, Song, Tian-Qiang, Zhang, Wei, Zeng, Zhi-Ming, Huang, Hua-Sheng, Wang, Kui, Huang, Lan-Qing, Chen, Yong-Jun, Yang, Yu-Chen, Zhou, Le-Du, Long, Guo, Zhao, Hai-Tao, Wang, Yun-Chao, Ge, Ning-Ling, Chen, Yi, Tan, Chang-Jun, Zhou, Jian, Fan, Jia, and Sun, Hui-Chuan

Published
2023
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9. Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial

Author

Liu, Xu, Zhang, Yuan, Yang, Kun-Yu, Zhang, Ning, Jin, Feng, Zou, Guo-Rong, Zhu, Xiao-Dong, Xie, Fang-Yun, Liang, Xiao-Yu, Li, Wen-Fei, He, Zhen-Yu, Chen, Nian-Yong, Hu, Wei-Han, Wu, Hai-Jun, Shi, Mei, Zhou, Guan-Qun, Mao, Yan-Ping, Guo, Rui, Sun, Rui, Huang, Jing, Liang, Shao-Qiang, Wu, Wei-Li, Su, Zhen, Li, Ling, Ai, Ping, He, Yu-Xiang, Zang, Jian, Chen, Lei, Lin, Li, Huang, Shao Hui, Xu, Cheng, Lv, Jia-Wei, Li, Ying-Qing, Hong, Shu-Bin, Jie, Yu-Sheng, Li, Hao, Huang, Sai-Wei, Liang, Ye-Lin, Wang, Ya-Qin, Peng, Ying-Lin, Zhu, Jin-Han, Zang, Sheng-Bing, Liu, Song-Ran, Lin, Qing-Guang, Li, Hao-Jiang, Tian, Li, Liu, Li-Zhi, Zhao, Hong-Yun, Lin, Ai-Hua, Li, Ji-Bin, Liu, Na, Tang, Ling-Long, Chen, Yu-Pei, Sun, Ying, and Ma, Jun

Published
2024
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37. A nomogram based on circulating CD8+ T cell and platelet-to-lymphocyte ratio to predict overall survival of patients with locally advanced nasopharyngeal carcinoma.

Author

Yan, Chang, Yang, Guohai, Zhang, Chaojun, Chen, KaiHua, Sun, Yongchu, Liang, Zhongguo, Lai, Lin, Li, Ling, Qu, Song, and Zhu, Xiao-Dong

Abstract

Purpose: To explore the influence of circulating lymphocyte subsets, serum markers, clinical factors, and their impact on overall survival (OS) in locally advanced nasopharyngeal carcinoma (LA-NPC). Additionally, to construct a nomogram predicting OS for LA-NPC patients using independent prognostic factors. Methods: A total of 530 patients with LA-NPC were included in this study. In the training cohort, Cox regression analysis was utilized to identify independent prognostic factors, which were then integrated into the nomogram. The concordance index (C-index) was calculated for both training and validation cohorts. Schoenfeld residual analysis, calibration curves, and decision curve analysis (DCA) were employed to evaluate the nomogram. Kaplan-Meier methods was performed based on risk stratification using the nomogram. Results: A total of 530 LA-NPC patients were included. Multivariate Cox regression analysis revealed that the circulating CD8+T cell, platelet-to-lymphocyte ratio (PLR), lactate dehydrogenase (LDH), albumin (ALB), gender, and clinical stage were independent prognostic factors for LA-NPC (p < 0.05). Schoenfeld residual analysis indicated overall satisfaction of the proportional hazards assumption for the Cox regression model. The C-index of the nomogram was 0.724 (95% CI: 0.669–0.779) for the training cohort and 0.718 (95% CI: 0.636-0.800) for the validation cohort. Calibration curves demonstrated good correlation between the model and actual survival outcomes. DCA confirmed the clinical utility enhancement of the nomogram over the TNM staging system. Significant differences were observed in OS among different risk stratifications. Conclusion: Circulating CD8+ T cell, PLR, LDH, ALB, gender and clinical stage are independent prognostic factors for LA-NPC. The nomogram and risk stratification constructed in this study effectively predict OS in LA-NPC. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Laser-assisted fabrication of a 3D cross-linked V2CTx/rGO microelectrode for high-rate aqueous zinc-ion microbatteries.

Author

Wu, Jiao, Liu, Long, Ren, Cai-Yun, Zhang, Yong-Chao, Gao, Jian, and Zhu, Xiao-Dong

Abstract

The high safety, compatible device size, superior energy density, and cost efficiency make in-plane aqueous zinc-ion microbatteries (AZIMBs) one of the most promising candidates for miniaturized energy storage. However, the inherent stacking structure within in-plane AZIMBs poses a hindrance to improving their energy density. Herein, this work presents a one-step approach for fabricating 3D cross-linked structures in V2CTx@rGO microelectrodes by laser processing technology, aiming to enhance the electrochemical performance of AZIMBs within a limited area by exploiting the vertical dimension of 3D architectures. The laser heat generated during laser processing induces the conversion of a 2D V2CTx@GO stacked structure into a 3D V2CTx@rGO skeleton structure, enabling the microelectrode to possess an optimal 3D conductive network, efficient charge transport pathway, and complete exposure of active sites. Moreover, the utilization of vanadium-based oxides derived from V2CTx MXene nanosheets on the surface during charging enhances the electrochemical performance of 3D AZIMBs. The obtained 3D VOx-V2CTx@rGO microelectrodes exhibit excellent rate performance, demonstrating an average reversible capacity ranging from 459 to 342 mA h g−1 at current densities varying from 0.8 to 2.5 A g−1, respectively. Additionally, the fabricated 3D VOx-V2CTx@rGO AZIMBs demonstrate exceptional flexibility and integrability, thus showing significant potential in microsized energy storage devices. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Treatment-Related Lymphopenia is Possibly a Marker of Good Prognosis in Nasopharyngeal Carcinoma: a Propensity-Score Matching Analysis.

Author

Weng, Ke-gui, Lei, Hai-ke, Shen, De-Song, Wang, Ying, and Zhu, Xiao-Dong

Subjects
NASOPHARYNX cancer, LYMPHOCYTE count, LYMPHOCYTE subsets, T cells, PROPENSITY score matching, PROGNOSIS, NASOPHARYNX tumors, LYMPHOPENIA
Abstract

Purpose: The aims of the study were to monitor circulating lymphocyte subset counts before and after therapy for nasopharyngeal carcinoma (NPC), and investigate their relationships with patient outcomes. Patients and Methods: Subjects comprised patients with TNM stage I–IVA NPC who underwent radiotherapy. Peripheral venous blood samples were collected before and after treatment. Lymphocyte subset counts were analyzed by flow cytometry. Differences between post-treatment and baseline counts were calculated to determine Δ values. Patients were divided into high and low groups, based on median lymphocyte subset counts; propensity score matching was applied to balance groups. Progression-free survival (PFS) and overall survival (OS) were plotted using Kaplan-Meier curves and compared using a Log rank test. Relationships between lymphocyte subset counts and patient survival were subjected to Cox regression analysis. Results: Patients with NPC (n=746) were enrolled from 2012– 2022. Higher CD8+ and total T cell baseline counts were associated with better 5-year PFS (73.7% vs 63.1%, P=0.002 and 73.8% vs 64.1%, P=0.005, respectively). Similarly, higher Δ values of CD4+ and total T cells were associated with higher 5-year PFS (76.2% vs 63.5%, P=0.001; 74.3% vs 65.4%, P=0.010) and OS (89.8% vs 81.6%, P=0.005; 88.6% vs 82.5%, P=0.009). Multivariate Cox regression revealed that CD8+ (hazard ratio (HR) 0.651, P=0.002) and total T (HR 0.600, P< 0.001) cells were significantly associated with PFS. CD4+ (HR 0.708, P=0.038) and total T (HR 0.639, P=0.031) cells were independent prognostic factors for OS. Conclusion: NPC patients with low total or CD8+ T cell counts before treatment had worse prognosis; however, those with more significant decreases in total or CD4+ T cells possibly had better outcomes. T cell counts can be reliable indicators to predict prognosis. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial

Author

Chen, Yu-Pei, Liu, Xu, Zhou, Qin, Yang, Kun-Yu, Jin, Feng, Zhu, Xiao-Dong, Shi, Mei, Hu, Guo-Qing, Hu, Wei-Han, Sun, Yan, Wu, Hong-Fen, Wu, Hui, Lin, Qin, Wang, Hui, Tian, Ye, Zhang, Ning, Wang, Xi-Cheng, Shen, Liang-Fang, Liu, Zheng-Zheng, Huang, Jing, Luo, Xiu-Ling, Li, Ling, Zang, Jian, Mei, Qi, Zheng, Bao-Min, Yue, Dan, Xu, Jing, Wu, San-Gang, Shi, Yan-Xia, Mao, Yan-Ping, Chen, Lei, Li, Wen-Fei, Zhou, Guan-Qun, Sun, Rui, Guo, Rui, Zhang, Yuan, Xu, Cheng, Lv, Jia-Wei, Guo, Ying, Feng, Hui-Xia, Tang, Ling-Long, Xie, Fang-Yun, Sun, Ying, and Ma, Jun

Published
2021
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