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6. [Preoperative localization of parathyroid lesions with Tc-99m-MIBI/iodine 123].

Author

Huglo D, Nocaudie M, Lecomte-Houcke M, Ziegels P, Bailliez A, Carnaille B, Proye C, and Marchandise X

Subjects
Adenoma diagnostic imaging, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Hyperparathyroidism pathology, Hyperparathyroidism surgery, Hyperplasia, Male, Microscopy, Electron, Middle Aged, Parathyroid Glands diagnostic imaging, Parathyroid Glands pathology, Parathyroid Glands ultrastructure, Radionuclide Imaging, Sensitivity and Specificity, Hyperparathyroidism diagnostic imaging, Iodine Radioisotopes, Technetium Tc 99m Sestamibi
Abstract

Objective: Assess the sensitivity of MIBI-Tc for the detection of parathyroid lesions and define the threshold of detection by evaluating contrast uptake at 20 minutes and 2 hours., Methods: Fifty-five operated and cured patients were studied. Image acquisitions were made 20 minutes and 2 hours after injection of 555 MBq MIBI-Tc then 2 hours after injection of 5.55 MBq iodine 123., Results: A total of 87 pathological glands were found including 47 adenomas (80 to 8820 mg) and 40 hyperplasias (44 to 2175 mg). Detection sensitivity was 81% for adenomas and 30% for hyperplasia, but the cell type did not appear to be a determining factor., Conclusion: Scintigraphic visualization of parathyroid lesions is more frequent when there is a single lesion. At least one lesion was seen in 80% of the patients. The threshold of detection was 225 mg. Enhancement of parathyroid uptake with MIBI-Tc compared with the thyroid between 20 minutes and 2 hours was not a constant and of unknown origin.

Published
1996

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