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In this paper, we discuss challenges associated with implementing a policy for Ancillary Care (AC) for related and unrelated (serious) adverse events during an Ebola vaccine trial conducted in a remote area of the Democratic Republic of the Congo. Conducting clinical trials in resource-constrained settings can raise context-related challenges that have implications for study participants' health and wellbeing. During the Ebola vaccine study, three participants were injured in road traffic accidents, but there were unexpected difficulties when trying to apply the AC policy. First, because of the nature of the adverse events, the insurer refused to cover the costs. Second, the AC policy did not address treatments by traditional medicine, even though traditional medicines are frequently used and highly trusted in the study community. This highlighted a contrast between the researchers' well-intentioned AC approach and the participants' legitimate preferences. The way in which researchers should address their responsibility to provide AC is not straightforward; it requires contextualization. Our experience highlights the importance of involving community representatives and the local ethics committee to ensure development of an AC policy that is culturally and ethically appropriate. Additionally, the insurance contract should clearly stipulate which adverse events are linked to the trial participation, and thus eligible for coverage, to avoid controversies when claims are made.

While attention dysregulation is a promising early indicator of neurodevelopmental risk, in particular attention-deficit/hyperactivity disorder (ADHD), it is difficult to characterize clinical concern due to its developmental expectability at the transition to toddlerhood. Thus, explicating the typical:atypical continuum of risk indicators is among the key future directions for research to promote early identification and intervention, and prevent decrements in the attainment of developmental milestones into early childhood. In this paper, we present the Multidimensional Assessment Profiles-Attention Regulation Infant-Toddler (MAPS-AR-IT) Scale, a novel parent-report survey of dimensional, developmentally specified indicators of attention (dys)regulation. Item Response Theory was employed to characterize the typical:atypical spectrum of both normative and more concerning dysregulation (including the contexts in which behavior occurs). We provide evidence of the validity of this measure in capturing the full typical:atypical spectrum via a longitudinal sample of typically developing children at 12-18 months of age (baseline) via concurrent scores on well-validated temperament and clinical measures. We also examine longitudinal stability and predictive validity if the MAPS-AR-IT via a clinical interview of ADHD symptoms at 24-30 months (follow-up). While not diagnostic, we present evidence of the utility of the MAPS-AR-IT in explicating individual neurodevelopmental risk and elucidating the broader typicality of behaviors related to attention (dys)regulation.

Le système de santé en Afrique connait des réalités difficilement supportables. A Kinshasa, les acteurs sociaux déforment, souvent, les fonctions réelles de structures hospitalières du fait qu'ils érigent des barrières pour les malades de se rendre aux consultations. Ceci est dû aux idées négatives reçues et partagées par la population de la République Démocratique du Congo. Ces postures imaginaires se constituent en facteurs socio-culturels qui entravent le travail des professionnels de la santé et entraînent, parfois, le manque à gagner chez ces professionnels et des décès dans les populations. Ceci pose aussi le problème des soins médicaux selon les visions ancestrales et modernes.

Abstract Background Systematic reviews are viewed as the best study design to guide clinical decision-making as they are the least biased publications assuming they are well-conducted and include well-designed studies. Cochrane was initiated in 1993 with an aim of conducting high-quality systematic reviews. We aimed to examine the publication rates of non-Cochrane systematic reviews (henceforth referred to simply as “systematic reviews”) and Cochrane reviews produced throughout Cochrane’s existence and characterize changes throughout the period. Methods This observational study collected data on systematic reviews published between 1993 and 2022 in PubMed. Identified Cochrane reviews were linked to data from the Cochrane Database of Systematic Reviews via their Digital Object Identifier. Systematic reviews and Cochrane reviews were analyzed separately. Two authors screened a random sample of records to validate the overall sample, providing a precision of 98%. Results We identified 231,602 (94%) systematic reviews and 15,038 (6%) Cochrane reviews. Publication of systematic reviews has continuously increased with a median yearly increase rate of 26%, while publication of Cochrane reviews has decreased since 2015. From 1993 to 2002, Cochrane reviews constituted 35% of all systematic reviews in PubMed compared with 3.5% in 2013–2022. Systematic reviews consistently had fewer authors than Cochrane reviews, but the number of authors increased over time for both. Chinese first authors conducted 15% and 4% of systematic reviews published from 2013–2022 and 2003–2012, respectively. Most Cochrane reviews had first authors from the UK (36%). The native English-speaking countries the USA, the UK, Canada, and Australia produced a large share of systematic reviews (42%) and Cochrane reviews (62%). The largest publishers of systematic reviews in the last 10 years were gold open access journals. Conclusions Publication of systematic reviews is increasing rapidly, while fewer Cochrane reviews have been published through the last decade. Native English-speaking countries produced a large proportion of both types of systematic reviews. Gold open access journals and Chinese first authors dominated the publication of systematic reviews for the past 10 years. More research is warranted examining why fewer Cochrane reviews are being published. Additionally, examining these systematic reviews for research waste metrics may provide a clearer picture of their utility.

Introduction Clear guidelines to implement ancillary care (AC) in clinical trials conducted in resource-constrained settings are lacking. Here, we evaluate an AC policy developed for a vaccine trial in the Democratic Republic of the Congo and formulate policy recommendations.Methods To evaluate the AC policy, we performed a longitudinal cohort study, nested in an open-label, single-centre, randomised Ebola vaccine trial conducted among healthcare personnel. Participants’ demographic information, residence distance to the study site and details on the financial and/or medical support provided for any (serious) adverse events ((S)AE) were combined and analysed. To assess the feasibility of the AC policy, an expenditure analysis of the costs related to AC support outcomes was performed.Results Enrolment in this evaluation study started on 29 November 2021. The study lasted 11 months and included 655 participants from the Ebola vaccine trial. In total, 393 participants used the AC policy, mostly for AE management (703 AE and 94 SAE) via medication provided by the study pharmacy (75.3%). Men had a 35.2% (95% CI 4.0% to 56.6%) lower likelihood of reporting AE compared with women. Likewise, this was 32.3% lower (95% CI 5.8% to 51.4%) for facility-based compared with community-based healthcare providers. The daily AE reporting was 78.8% lower during the passive vs the active trial stage, and 97.4% lower during unscheduled vs scheduled visits (p

Background: The lingula of the mandible is a small tongue-shaped bony prominence that partially overlaps the mandibular foramen. It has variable shapes among different populations which impacts its significance as a bony landmark in maxillofacial and oral surgeries. This study aimed to explore the morphological and morphometric characteristics of the mandibular lingula in dry mandibles of a South African population, to provide more knowledge on its structural variations, and location for surgeons involved with maxillofacial and oral surgeries. Methodology: The study utilized 45 (n = 90 sides) dry human mandibles. The shapes were classified into five types, as per the classification scheme proposed by Tuli et al. (2000) and Varma and Sameer (2013). Three morphometric parameters were utilized to determine the location of the lingula. A p-value of

COVID-19 vaccination in the Democratic Republic of the Congo (DRC) began in April 2021. A month later, most COVID-19 vaccine doses were reallocated to other African countries, due to low vaccine uptake and the realization that the doses would expire before use. Based on data available on 13 August 2022, 2.76% of the DRC population had been fully vaccinated with last dose of primary series of COVID-19 vaccine, placing the country second to last in Africa and in the last five in global COVID-19 vaccination coverage. The DRC's reliance on vaccine donations requires continuous adaptation of the vaccine deployment plan to match incoming COVID-19 vaccines shipments. Challenges in planning vaccine deployments, vaccinating priority populations, coordinating, and implementing the communications plan, disbursing funds, and conducting supervision of vaccination activities have contributed to low COVID-19 vaccine coverage. In addition, the spread of rumors through social media and by various community and religious leaders resulted in high levels of vaccine hesitancy. A strong risk communication and community engagement plan, coupled with innovative efforts to target the highest-risk populations are critical to increase vaccine uptake during the next phase of COVID-19 vaccine introduction.

Isu agama merupakan salah satu dari faktor yang sering menimbulkan ketegangan dalam kehidupan sosial masyarakat Tujuan dari penelitian ini adalah untuk mengetahui dinamika komunikasi antabudaya di Surokarsan kota Yogyakarta. Penelitian ini merupakan penelitian kualitatif. Subjek dalam penelitian ini yaitu sekretaris umum kerokhanian Sapta Darma, ketua persatuan warga Sapta Darma (Persada) kota Yogyakarta, warga anggota penganut Sapta Darma. Hasil penelitian menujukkan bahwa Komunikasi antarbudaya yang dilakukan oleh Sapta Darma Yogyakarta menyajikan contoh bahwa eksklusivitas hanya akan menghambat terciptanya integrasi sosial. Sebaliknya, sikap terbuka dan menghomati perbedaan keyakinan merupakan kunci penting dalam memperkuat persatuan. Komunikasi antarbudaya yang inklusif dapat meredam potensi meletusnya konflik horizontal yang berbasis sentimen agama. Kata Kunci: Komunikasi Antarbudaya, Sapta Darma, Integrasi Sosial

Essential treatments for patients with end-stage renal disease include Renal Replacement Therapy (RRT) consisting of hemodialysis, peritoneal dialysis, and kidney transplantation. In 2014, dialysis coverage in Indonesia was more than 1.5 trillion, making it the second highest expense in the National Health Insurance (BPJS) expenses. This study compared the cost-effectiveness between Continuous Ambulatory Peritoneal Dialysis (CAPD) and Hemodialysis (HD) in patients treated in Dr. Hasan Sadikin General Hospital. Data were collected from the Urology Department from 2014 to 2017. This was a retrospective observational study on 3 groups of patients: patients with effective CAPD each year as the first group; patients who had experienced repair of CAPD and continued to use it as the second group; and patients who discontinued CAPD due to complications and returned to hemodialysis as the third group. Each group expense was calculated with standard cost insurance for one year in the hospital. The expense was then be compared to the expense of hemodialysis for one year. A total of 89 patients in the CAPD program from 2014–2017 were treated at the department. When compared to HD, the first, second, and third group of CAPD patients experienced a cost reduction of IDR 23.227.857/person, IDR 18.127.857/person, and IDR 1.661.972.000, respectively. Total savings from the CAPD program in the hospital was IDR 1.661.972.000 from 2014. It is then concluded that CAPD could reduce the burden of government insurance in a cost-effective manner and is considered a treatment of choice in the National Health Insurance Era.

This study examines the effectiveness of networking simulation tools, particularly Cisco Packet Tracer, in enhancing the learning experiences of exit-level students at a higher education institution based in the Eastern Cape of South Africa. Utilizing the Context, Input, Process, and Product (CIPP) evaluation model, the research assesses these tools’ impact, effectiveness, and sustainability in a resource-constrained, rural-based higher education context. The findings indicate that simulation tools significantly improve students’ practical skills, understanding of theoretical concepts, and preparedness for professional work in computer networking. Despite challenges such as software crashes and compatibility issues, the benefits of using simulation tools, including cost-effectiveness and convenience, are evident. The study concludes that, while simulation tools are valuable, continuous improvements and support are necessary to maximize their educational potential.

Recently, the use of fingerprinting has been proposed for positioning using the Wi-Fi RTT estimations gathered by IEEE 802.11mc devices. Wi-Fi RTT poses a challenge on scalability due to the location-specific traffic injected in the network, which may limit the data traffic transmissions of other Wi-Fi users. In this respect, fingerprinting has been regarded as a promising scalable technique, compared to multilateration. While coupling other metrics should bring relief to the system, reducing the number of APs to which RTT measurements are requested alleviates the burden in specific cells. But how far may we go? This paper assesses several methods aimed at reducing the Wi-Fi RTT overhead while preserving the precision of the calculated position. The use of the Wi-Fi RTT standard deviation is assessed for the first time, being especially useful when the number of RTT procedures is minimized. The application of clustering can also improve position estimates while leveraging bandwidth for other users’ purposes.

We investigate the diffusion phenomenon of particles in the vicinity of a spherical colloidal particle where particles may be adsorbed/desorbed and react on the surface of the colloidal particle. The mathematical model comprises a generalized diffusion equation to govern bulk dynamics and kinetic equations which can describe non-Debye relaxations and is used for the colloid’s surface. For the reaction processes, we also consider the presence of convolution kernels, which offer the flexibility of describing a single process or process with intermediate reactions before forming the final species. Our analysis focuses on analytical and numerical calculations to obtain the particles’ behavior on the colloidal particle’s surface and to determine how it affects the diffusion of particles around it. The solutions obtained show various behaviors that can be connected to anomalous diffusion phenomena and may be used to describe the ever-richer science of colloidal particles better.

Reducing marginal bone resorption is a challenge in implant dentistry. Sub-gingival implant placement has been suggested as a suitable strategy to avoid long-term esthetic and biological complications. A total of 38 healthy patients received bone-level (BLG-Control) or 2 mm sub-crestal (SCG-Test) conical connection, platform-switched implants. The test group received an immediate tissue-level abutment, following the one-time abutment (OTA) concept. Marginal bone modification (MBM) was calculated on standardized radiographs at surgery (T0), loading (T1), and 6 (T2) and 12 (T3) months after loading and classified as bone loss (BL) if it occurred below the implant neck and bone remodeling (BR) if above. Pocket-probing depth (PPD), Bleeding on probing (BoP), and Plaque Index (PI) were collected. At 12 months, the mean MBM was 0.61 mm in the test group and 0.52 mm in the control group. In all the cases of the test group (SCG), MBM occurred only above the implant neck, therefore being classified as BR, and no BL was observed. In the control group (BLG), MBM occurred below the implant neck, thus corresponding entirely to BL. The test group had an average PPD of 2.38 mm compared to 3.04 mm in the control group, with BoP at 50% and 43%, and PI at 33% and 19.44%, respectively. At one year after loading, sub-crestal conical connection, platform-switched implants show comparable MBM to bone level implants; however, no bone loss was observed.

This research paper delves into the contrasting interpretations of the muse by Mary Wollstonecraft and William Wordsworth, as evidenced in their seminal works A Vindication of the Rights of Woman and the Preface to Lyrical Ballads, respectively. The paper critically evaluates how each interpretation shapes contrasting truths about the production and consumption of literature. Wollstonecraft, advocating for reason as her muse, challenges societal norms and seeks to empower women through education. In contrast, Wordsworth embraces feeling as his muse, aiming to directly communicate with the heart of his reader. Through a comparative analysis, this paper explores how these distinct muses inform the authors’ approaches to subjects such as education, uniformity, and gender. Furthermore, it examines the Rousseauvian influences on their views, and how each author’s position of power shapes their narrative. Ultimately, it highlights the radical nature of both texts in the democratisation of poetry and the elevation of the female sex.

Background: Inpatient suicide is a serious adverse event in psychiatric wards. Suicide can cause severe trauma to both patients and health professionals, who may develop maladaptation with poor coping skills. Healthcare practitioners are the second victims and historically, this concept has been overlooked. The psychological effects and lack of support have not been sufficiently explored. Aim: The emotional well-being and clinical practice of nurses who experienced inpatient suicide at Weskoppies Psychiatric Hospital was explored. Setting: Weskoppies Psychiatric Hospital, South Africa. Methods: In this qualitative case study, 12 nurses who had lost a patient to inpatient suicide some time during their employment were purposefully selected. Data were collected through individual in-depth interviews, which were audio recorded and transcribed. The data were thematically analysed. Results: Nurses were negatively affected by inpatient suicide resulting in a range of emotional and psychological effects, including fear, anger, sadness, flashbacks, guilt, and difficulty in coping. Clinical practice factors included being doubtful and extra vigilant. Although nurses received psychological support from the institution, they recommended in-service training with periodic reviews to prevent and manage inpatient suicide. Conclusion: Inpatient suicide is a serious adverse event, and mental health practitioners become second victims. These events do not only impact the psychological well-being of nurses but also influence the clinical practice. Mental health practitioners should receive adequate training and support in preventing and handling inpatient suicide. Contribution: This study provided insights into nurse’s perspectives on the effects of inpatient suicide and how they can be supported.

Background This study performed a systematic review and meta-analysis to compare the outcomes of the staged laparoscopic Fowler-Stephens Laparoscopic Orchiopexy (FSLO) and Staged Laparoscopic Traction Orchiopexy (SLTO) in patients with intra-abdominal testes (IAT). Methods This study reviewed literature published from 2016 to 2024. A systematic literature search was conducted on three databases: PubMed, ScienceDirect, and Google Scholar, using keywords (High intra abdominal testis) AND (("Fowler Stephens laparoscopic orchiopexy" OR (FSLO)) OR (Staged Laparoscopic traction orchiopexy OR (SLTO)). Non-randomized trials and observational studies comparing staged laparoscopic FSLO and SLTO, without any time range restriction are included. Studies without FLSO orchidopexy as a control, case reports, case studies, duplicate publication, no full text and non-English studies are excluded. This study used the PRISMA protocol, the Jadad Scale, and the Newcastle Ottawa Scale (NOS) to evaluate the included studies. To analyze statistical data, the Review Manager (RevMan) software was used. The Chi-squared test was used to calculate statistical heterogeneity in the meta-analysis. Results There were 240 patients from 5 studies (109 in the SLTO group and 131 FSLO in group). The primary outcome of this study is testicular descent and atrophy. There were no significant differences in testicular descent (RR:1.08[0.96 – 1.23],p

IntroductionBased on a large body of previous research suggesting that smell loss was a predictor of COVID-19, we investigated the ability of SCENTinel®, a newly validated rapid olfactory test that assesses odor detection, intensity, and identification, to predict SARS-CoV-2 infection in a community sample.MethodsBetween April 5, 2021, and July 5, 2022, 1,979 individuals took one SCENTinel® test, completed at least one physician-ordered SARS-CoV-2 PCR test, and endorsed a list of self-reported symptoms.ResultsAmong the of SCENTinel® subtests, the self-rated odor intensity score, especially when dichotomized using a previously established threshold, was the strongest predictor of SARS-CoV-2 infection. SCENTinel® had high specificity and negative predictive value, indicating that those who passed SCENTinel® likely did not have a SARS-CoV-2 infection. Predictability of the SCENTinel® performance was stronger when the SARS-CoV-2 Delta variant was dominant rather than when the SARS-CoV-2 Omicron variant was dominant. Additionally, SCENTinel® predicted SARS-CoV-2 positivity better than using a self-reported symptom checklist alone.DiscussionThese results indicate that SCENTinel® is a rapid assessment tool that can be used for population-level screening to monitor abrupt changes in olfactory function, and to evaluate spread of viral infections like SARS-CoV-2 that often have smell loss as a symptom.

Several countries have developed instruments to explore meaning of life for their citizens, in Indonesia, there has not been a concerted effort to create similar tools. The search for meaning of life remains a philosophical and personal question that has not received significant attention from the government or official institutions. As a society, a clear direction in achieving life goals without official guidance or adequate instruments to guide have continually been seek. This research objective to develop Meaning of Life Scale (MoLS) to explore and understand the significance of life of students. MoLS was administered to 207 respondents consisting of 72% females and 28% males, and data analysis was conducted using Rasch-based method. The results showed that MoLS was valid and reliable, while the 17-item of MoLS was successful at measuring the significance of life of students without gender bias. This research tends to have important implications in the fields of psychology and well-being, providing valuable insight for research and practitioners in understanding the role and influence of meaning of life of students.

Background: The role of inflammation is an important part for the process of acute myocardial infarction. Inflammation of blood vessel walls and inflammatory response are considered as the main pathogenesis of atherothrombosis in ST elevation of myocardial infarction. Hs-CRP can measure the inflammatory response after acute myocardial infarction thereby providing prognosis for major adverse cardiovascular event. Objective: This study aims to the serum levels of Hs-CRP at admission as a predictor of a Major Adverse Cardiovascular Event (MACE), including cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, stent thrombosis in STEMI patient who underwent primary percutaneous intervention (PPCI) during hospitalization and 30 days after primary percutaneous coronary intervention. Methods: This study was a prospective observational cohort study. Subjects were patients with a diagnosis of onset

Abstract Assessing patterns and evolution of insecticide resistance in malaria vectors is a prerequisite to design suitable control strategies. Here, we characterised resistance profile in Anopheles gambiae and Anopheles funestus in Kinshasa and assess the level of aggravation by comparing to previous 2015 estimates. Both species collected in July 2021 were highly resistant to pyrethroids at 1×, 5× and 10× concentrations (mortality

We investigate the H-theorem for a class of generalized kinetic equations with fractional time-derivative, hyperbolic term, and nonlinear diffusion. When the H-theorem is satisfied, we demonstrate that different entropic forms may emerge due to the equation’s nonlinearity. We obtain the entropy production related to these entropies and show that its form remains invariant. Furthermore, we investigate some behaviors for these equations from both numerical and analytical perspectives, showing a large class of behaviors connected with anomalous diffusion and their effects on entropy.

Many fundamental physical problems are modeled using differential equations, describing time- and space-dependent variables from conservation laws. Practical problems, such as surface morphology, particle interactions, and memory effects, reveal the limitations of traditional tools. Fractional calculus is a valuable tool for these issues, with applications ranging from membrane diffusion to electrical response of complex fluids, particularly electrolytic cells like liquid crystal cells. This paper presents the main fractional tools to formulate a diffusive model regarding time-fractional derivatives and modify the continuity equations stating the conservation laws. We explore two possible ways to introduce time-fractional derivatives to extend the continuity equations to the field of arbitrary-order derivatives. This investigation is essential, because while the mathematical description of neutral particle diffusion has been extensively covered by various authors, a comprehensive treatment of the problem for electrically charged particles remains in its early stages. For this reason, after presenting the appropriate mathematical tools based on fractional calculus, we demonstrate that generalizing the diffusion equation leads to a generalized definition of the displacement current. This modification has strong implications in defining the electrical impedance of electrolytic cells but, more importantly, in the formulation of the Maxwell equations in material systems.

Abstract The exact link between systemic and ocular endogenous corticoids (steroidome) is unclear and whether the ocular steroidome is altered in CSCR eyes is unknown. The aims of this study were to analyze the human steroidome in the aqueous humor as a function of age, sex and time of the day, to correlate systemic and ocular steroidome and to analyze the ocular steroidome in long lasting complex inactive CSCR. Based on our results, we present two CSCR cases treated by the combination of oral mineralocorticoid antagonist and glucocorticoids drops. In a cross-sectional study, aqueous humor (AH) was collected between 8am and 6 pm from 50 unaffected individuals (25 men and 25 women) and from 14 patients with chronic CSCR, during cataract surgery. In addition, simultaneous serum and AH were collected from 27 individuals undergoing cataract surgery and, simultaneous AH and vitreous were collected from 9 patients undergoing cataract and vitrectomy to estimate corticoids levels in the different compartments. The steroidome was determined using a LC–MS/MS method that quantifies 13 endogenous corticoids from the gluco, mineralocorticoid and androgen pathways. In AH and vitreous, the highest corticoid level is reached by cortisol (F), that represents less than 10% of F serum level. The cortisol levels in the serum did not correlate with ocular cortisol levels. Serum and ocular cortisone (E) levels correlate, although less than 5% of circulating E reaches the eye. The only mineralocorticoids measured in the AH were corticosterone (B) and its inactive form, the 11-desoxycorticosterone (A). There was no influence of circadian rhythm on cortisol ocular levels and there was no correlation between the age or the sex and the level of F, E, A, and B. In eyes with chronic inactive CSCR, the levels of the active glucocorticoid form F was lower than in control eyes and the F/E ratio was reduced by 50% but the B/A ratio was higher indicating imbalance towards active mineralocorticoids. Base on this observation, we propose to combine an antagonist of the mineralocorticoid receptor together with topical glucocorticoids in two CSCR patients, resistant to all other treatments, with favorable outcome. Our results indicate that the ocular psteroidome is highly regulated suggesting a local metabolism of ocular corticoids. In eyes with long-lasting complex inactive CSCR, the steroidome analysis shows lower active glucocorticoids and higher active mineralocorticoids.

Abstract Background: Despite a high incidence of sickle cell anemia, hydroxyurea (HU) treatment is rarely used in the DR Congo. This study aims to assess the efficacy of HU, the incidence of side effects that may limit its use in adults and to determine the dose needed for clinical improvement in patients. Methods: In a prospective study, patients received an initial dose of 15 mg/kg/day which was increased by 5 mg/kg every 6 months, up to a maximum of 30 mg/kg/day. The response and side effects to HU were evaluated biologically and clinically every 3 months during a 2‐year period. Results: Seventy adult patients with a moderate or severe clinical phenotype initiated treatment. Only minor side effects were reported. At the end of the 2‐year treatment phase, 45 (64.3%) had dropped out, of whom 33 were without a clear reason. Clinical and biological improvement was more marked during the first year. There was a reduction in severe vaso‐occlusive crises (p

This paper attempts to provide a procedure establishing perfect multilingualism. Apart from the two items related to gender and age, the author uses ten items based on socio-psycholinguistic parameters, namely the speaker’s emotional expression languages and easier languages. An illustrative study consisting of a survey and a semi-structured interview show how the procedure is implemented. The results reveal that the twenty respondents of the Department of English, Business and Computer Science of the university of Kinshasa have French and Lingala as perfect mother tongues and most of them speak Kinshasa Lingala native like.

Abstract Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies. However, distinguishing tauopathies ante mortem remains challenging, potentially due to differences between insoluble tau in aggregates and soluble tau in body fluids. Here, we demonstrated that tau isoforms differ between tauopathies in insoluble aggregates, but not in soluble brain extracts. We therefore characterized post-translational modifications of both the aggregated and the soluble tau protein obtained from post mortem human brain tissue of patients with Alzheimer’s disease, cortico-basal degeneration, Pick’s disease, and frontotemporal lobe degeneration. We found specific soluble signatures for each tauopathy and its specific aggregated tau isoforms: including ubiquitination on Lysine 369 for cortico-basal degeneration and acetylation on Lysine 311 for Pick’s disease. These findings provide potential targets for future development of fluid-based biomarker assays able to distinguish tauopathies in vivo.

We report the study of a huge optical intraday flare on 2021 November 12 at 2 a.m. UT in the blazar OJ 287. In the binary black hole model, it is associated with an impact of the secondary black hole on the accretion disk of the primary. Our multifrequency observing campaign was set up to search for such a signature of the impact based on a prediction made 8 yr earlier. The first I -band results of the flare have already been reported by Kishore et al. (2024). Here we combine these data with our monitoring in the R -band. There is a big change in the R – I spectral index by 1.0 ± 0.1 between the normal background and the flare, suggesting a new component of radiation. The polarization variation during the rise of the flare suggests the same. The limits on the source size place it most reasonably in the jet of the secondary BH. We then ask why we have not seen this phenomenon before. We show that OJ 287 was never before observed with sufficient sensitivity on the night when the flare should have happened according to the binary model. We also study the probability that this flare is just an oversized example of intraday variability using the Krakow data set of intense monitoring between 2015 and 2023. We find that the occurrence of a flare of this size and rapidity is unlikely. In machine-readable Tables 1 and 2, we give the full orbit-linked historical light curve of OJ 287 as well as the dense monitoring sample of Krakow.

Introduction Infectious diseases (IDs) constitute a real public health problem in the Democratic Republic of the Congo (DRC). Purpose This survey aimed to gather more information about the plants used in the DRC for anti-infective, larvicidal, or repellent treatments. Methods The study spanned 4 months (from April 1 to July 31, 2022) within 11 provinces in the DRC and was conducted among 20 traditional healers (TH), 105 vegetable growers (VG), and 953 other plant users (OU) of traditional plants scattered across the country. The survey consisted of a simple interview with an inventory of the plants used. Results The results showed that the average age of the respondents was between 39 and 43 years old. The VG were mainly illiterate. As for TH and OU, literacy rates up to the primary level were 60% and 78%, respectively. The knowledge of the use of plants by the various actors of traditional medicine in this survey emanates from the cultural heritage. For this study, 132 plant species (104 identified and 28 unidentified based on their botanical name or family) were reported. 33 antimicrobial species and 7 larvicidal species belonging to 22 botanical families have been reported among TH, while 1 and 75 antimicrobial species, 6 and 16 larvicidal species, and 13 and 30 repellent species were respectively identified among VG and OU. This study identified Morinda morindoides, Cymbopogon citratus, and Boswellia sacra as the plant species most used by the individuals surveyed for anti-infective, larvicidal, and repellent treatments, respectively, by their citation frequencies, which were the highest. Additionally, the leaves represented the plant parts most used by the respondents. Conclusion This ethnobotanical analysis revealed that most herbal antimicrobial recipes are used to treat malaria. This study confirms the richness of the Congolese flora concerning anti-infective, larvicidal, and repellent treatments.

Objective: The aim of this study is to provide the characteristics, management, and outcome of bladder trauma at the center of trauma referral hospital in West Java, Indonesia. Material & Methods: This is a retrospective and descriptive study. The data of bladder trauma were collected from the medical records from January 2010 to December 2019. The data were presented using descriptive statistics in frequency and percentage. Results: Over a ten-year period, there were 1,174 cases of urogenital trauma, with 170 cases (14.48%) involving bladder injuries. The majority of the was 21-30 years old and were men (55.88%). The most common cause was blunt abdominal trauma (68.82%), which was caused by traffic accidents (91.45%). With 42.24% pelvic fracture as the most common associated injury. The most common type of bladder injury (45.88%) was bladder contusion. Iatrogenic trauma was the second leading causes (29.42%) with obstetrics and gynecology operations accounted for 84% of iatrogenic bladder trauma cases. The majority of bladder injuries were identified using a computed tomography (CT) scan. In 59.41% of cases, surgical intervention was required. The mortality rate was 2.94% during post-operative treatment due to coexisting or associated multiple injuries. Conclusion: We discovered that bladder trauma most commonly affects males of reproductive age with blunt abdominal trauma as the most common etiology and pelvic fractures as the most common associated injury. Surgical intervention often was required. Keywords: Bladder injury, blunt abdominal trauma, iatrogenic bladder injury.

As avenidas de fundo de vale são elementos estruturais na metrópole de São Paulo. Este artigo pretende caracterizar seu subproduto, o “canal viário”, identificando suas particularidades morfológicas e programáticas. As análises responsáveis pela caracterização do canal viário foram realizadas ao longo de suas faixas de influência, em três escalas – observador, local e municipal, considerando a morfologia, os modais existentes e a configuração do sistema viário, a densidade demográfica, o uso do solo predominante e a evolução histórica da ocupação urbana. A caracterização espacial, urbana e morfológica dos canais viários resultou na identificação de sua recorrência na estruturação físico-espacial do Município de São Paulo e na identificação de seu potencial de transformação urbano-ambiental para a reconstrução da paisagem paulistana sobre sua matriz hidrográfica original.

Objective: Fournier's gangrene is a rare but life-threatening infection disease with high mortality rate. The quick Sepsis-related Organ Failure Assessment (qSOFA) is a new and simpler scoring system that may identify patients with suspected infection who are at greater risk for a poor outcome. The purpose of this study was to find out role of qSOFA in determining prognosis of Fournier's gangrene patients. Methods: This study is a case control with retrospective review of Fournier's gangrene patients treated at Hasan Sadikin Hospital from January 2013 to December 2017 who met inclusion criteria. Participants were divided into two groups according to qSOFA score as high qSOFA (2–3) and low qSOFA (0–1). Results: From 69 patients, the mortality rate was 24.6%. The sensitivity of qSOFA score to predict mortality was 88.2%; the specificity was 94.2%; positive predictive value was 83.3%; negative predictive value was 96.1%; positive likelihood ratio was 15.2; negative likelihood ratio was 0.12; and the area under the receiver operating characteristic curve of qSOFA was 94.2%. There was significant association between qSOFA scale and mortality with p-value of 0.0001. The qSOFA score has strong positive correlation with Fournier's Gangrene Severity Index (p

In industrial environments there are critical devices, so their correct operation must be ensured. In particular, having a secure record of the different events related to these devices is essential. Thus, this record can be used in future forensic investigations in case of accidents or production failures. In this sense, blockchain technology can bring reliability to the event log. In this paper, ChronoEOS 2.0, an extension of ChronoEOS, is presented. This new version can record the events that occur in multiple industrial robotic arms by deploying a Smart Contract in the EOSIO blockchain so that all events are immutably recorded in the blockchain. Furthermore, the new version allows using a unique fingerprint of the robot before registering an event in the blockchain. This fingerprint depends only on the characteristics of the operation and configuration of the robot. For this reason, ChronoEOS 2.0 not only increase the ability of ChronoEOS in terms of handling multiple devices but also increases the security and reliability of the operations. Finally, in this study, we verify that the new improvements have little impact on the hosting resources (RAM and Network are not altered, while CPU consumption is slightly higher due to the device fingerprinting module).

This study aimed to evaluate scientific evidence of the benefit of the use of insecticide-treated nets (ITNs) and Intermittent preventive treatment (IPT) on the birth weight of newborns and the hemoglobin level of the mother when used to prevent malaria during pregnancy. This cross-sectional analytical study was conducted on 467 hospitalized women in the Maternity Ward of Centre Hospitalier de Kingasani II, in the Democratic Republic of the Congo. Data were collected using a structured questionnaire that was pre-tested during a face-to-face interview. Apart from basic statistics, the chi-square test was used to compare proportions. Multivariate analysis (logistic regression) was used to identify variables significantly associated with the 95% confidence interval (CI). The ITN ownership rate was 81% (95% CI: 77–84) and the ITN use rate was 66% (95% CI: 62–70). Sixty-five percent (95% CI: 60–69) reported having received at least three doses of IPT during pregnancy with sulfadoxine-pyramethemine (IPTp-SP). There was a statistically significant difference in hemoglobin levels between hospitalized women who did not use the ITN (9.4 g/dL IIQ: 8.7–9.9) and those who did (11 g/dL IIQ: 9.8–12.2). The non-use of the ITN was associated with low birth weight (aOR = 3.6; 95% CI: 2.1–6.2; p < 0.001) and anemia in pregnant women (cOR = 2.41; 95% CI: 1.16–5.01; p = 0.018). The use of ITN and taking at least three doses of ITP during pregnancy are associated with good birth weight. The number of doses of IPTp received during antenatal care is associated with the maternal hemoglobin level in the third trimester of pregnancy.

The interplay of diffusion with phenomena like stochastic adsorption–desorption, absorption, and reaction–diffusion is essential for life and manifests in diverse natural contexts. Many factors must be considered, including geometry, dimensionality, and the interplay of diffusion across bulk and surfaces. To address this complexity, we investigate the diffusion process in heterogeneous media, focusing on non-Markovian diffusion. This process is limited by a surface interaction with the bulk, described by a specific boundary condition relevant to systems such as living cells and biomaterials. The surface can adsorb and desorb particles, and the adsorbed particles may undergo lateral diffusion before returning to the bulk. Different behaviors of the system are identified through analytical and numerical approaches.

To date, the SARS-CoV-2 pandemic still represents a great clinical challenge worldwide, and effective anti-COVID-19 drugs are limited. For this reason, nutritional supplements have been investigated as adjuvant therapeutic approaches in disease management. Among such supplements, vitamin D has gained great interest, due to its immunomodulatory and anti-inflammatory actions both in adult and pediatric populations. Even if there is conflicting evidence about its prevention and/or mitigation effectiveness in SARS-CoV-2 infection, several studies demonstrated a strict correlation between hypovitaminosis D and disease severity in acute COVID-19 and MIS-C (multisystem inflammatory syndrome in children). This narrative review offers a resume of the state of the art about vitamin D’s role in immunity and its clinical use in the context of the current pandemic, specially focusing on pediatric manifestations and MIS-C. It seems biologically reasonable that interventions aimed at normalizing circulating vitamin D levels could be beneficial. To help clinicians in establishing the correct prophylaxis and/or supportive therapy with vitamin D, well-designed and adequately statistically powered clinical trials involving both adult and pediatric populations are needed. Moreover, this review will also discuss the few other nutraceuticals evaluated in this context.

Background: This study performed a systematic review and meta-analysis to compare the outcomes of the staged laparoscopic Fowler-Stephens Laparoscopic Orchiopexy (FSLO) and Staged Laparoscopic Traction Orchiopexy (SLTO) in patients with intra-abdominal testes (IAT). Methods: This study reviewed literature published from 2016 to 2023. A systematic literature search was conducted on three databases: PubMed, ScienceDirect, and Google Scholar, using keywords (High intra abdominal testis) AND (("Fowler Stephens laparoscopic orchiopexy" OR (FSLO)) OR (Staged Laparoscopic traction orchiopexy OR (SLTO)). Non-randomized trials and observational studies comparing staged laparoscopic FSLO and SLTO, without any time range restriction are included. Studies without FLSO orchidopexy as a control, case reports, case studies, duplicate publication, no full text and non-English studies are excluded. This study used the PRISMA protocol, the Jadad Scale, and the Newcastle Ottawa Scale (NOS) to evaluate the included studies. To analyze statistical data, the Review Manager (RevMan) software was used. The Chi-squared test was used to calculate statistical heterogeneity in the meta-analysis. Results: This study included four studies of 151 patients (72 SLTO group and 79 FSLO group). There was no significant difference between the two groups in terms of testicular descent (p=0.08), and there was no testicular atrophy in the SLTO group compared to the FSLO group (p=0.04). Statistical analysis revealed a significantly shorter first-stage operation time in the FSLO group (p 0.0001), whereas the SLTO group reported a significantly shorter second-stage operation time (p = 0.04). Conclusions: In terms of testicular descent, the SLTO technique yields similar results to the FSLO technique. The SLTO position is preferable to the FSLO position. Both techniques have advantages and disadvantages, and we recommend SLTO as the first choice in children with a high IAT of 4 cm. PROSPERO registration: CRD42023412407