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Introduction: Ameloblastic fibro‑odontoma (AFO) is a rare, slow‑growing neoplastic lesion classified as a benign, epithelial odontogenic mesenchymal tumor. This tumor exhibits histological features characteristic of both ameloblastic fibromas and complex odontomas. The clinical manifestation of AFO is typically characterized by the asymptomatic enlargement of the jawbones. Radiographically, it presents as a distinct radiolucent region, indicating the presence of radiopaque substances with varying degrees of irregularities in size and morphology. Standard therapeutic intervention involves enucleation. Despite its benign nature, AFO can cause significant morbidity if left untreated. Therefore, prompt diagnosis and appropriate management are essential to ensure optimal patient outcomes. The present study described the case (clinical presentation and management) of a 10‑year‑old male patient with an AFO lesion located in the posterior mandible. This particular case was treated with conservative measures involving surgical enucleation along with the extraction of the impacted tooth and the curettage of residual bone.

We report a case of ameloblastic fibro-odontoma (AFO) in the second molar region of the left mandible of an 8-year-old girl. Cone beam computed tomography revealed a spatial relationship between the lesion and the gubernaculum tract of an unerupted second molar. Histologically, characteristic multinodular growth of discrete tooth germ-like structures supported the non-neoplastic hamartomatous nature of the lesion. The pattern and degree of syndecan-1 and D2-40 immunoexpression in the epithelial component varied, probably reflecting different stages of maturation. In view of the patient's age (<13 years) and the size of the lesion (<2 cm), the present AFO was likely a developing odontoma. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor composed of proliferating odontogenic epithelium in a cellular ectomesenchyme with the formation of dental hard tissues, including enamel and dentin. According to the 2017 WHO Classification of Head and Neck Tumours, AFO is no longer defined as an independent entity but as part of a series of histological changes observed in a developing odontoma (DOD). Nevertheless, it is believed that this classification does not apply to all lesions diagnosed as AFO before 2017, some of which have neoplastic characteristics with BRAF p.V600E mutation. We report a case of DOD in the posterior mandible of an 8-year-old girl. Surgical excision was performed under general anesthesia. This case was diagnosed based on detailed clinical, radiological, and histopathological analyses. In addition, the mutant BRAF p.V600E was suspected by immunohistochemical analysis. BRAF mutation detection may contribute to accurately diagnosing the true neoplastic nature in odontomas. In the present case, no recurrence was observed until at least 11 months after surgery. [ABSTRACT FROM AUTHOR]

Until the 3rd edition, ameloblastic fibroma, ameloblastic fibro-odontoma, ameloblastic fibrodentinoma, and odontoma were classified as distinct entities within the category of mixed odontogenic tumors.[2],[3] Graph: Figure 1. Keywords: ameloblastic fibro-odontoma; ameloblastic fibrodentinoma; odontogenic tumors; WHO classification EN ameloblastic fibro-odontoma ameloblastic fibrodentinoma odontogenic tumors WHO classification 1508 1512 5 11/02/23 20231201 NES 231201 The World Health Organization (WHO)[1] defines benign mixed odontogenic tumors as tumors composed of odontogenic epithelium and ectomesenchyme that can show inductive changes, including the formation of dental hard tissues. Awareness of these rare entities can create a bias towards overdiagnosing odontomas as ameloblastic fibro-odontoma/ameloblastic fibrodentinoma; likewise, consensus guidelines can create a bias of underdiagnosing ameloblastic fibro-odontoma/ameloblastic fibrodentinoma as odontoma. [Extracted from the article]

Odontomas are considered hamartomatous lesions and are one of the two most common odontogenic tumors of the jaw. Odontomas are classified as compound or complex. Recently, ameloblastic fibro-odontoma (AFO) and ameloblastic fibro-dentinoma were reclassified as developing odontomas. Though clinically odontomas are usually asymptomatic, they have adverse effects on adjacent teeth such as tooth impaction, delayed eruption, displacement of teeth, over-retention of teeth, and can give rise to odontogenic cysts within the jaw. We sought to evaluate the clinicoradiopathologic presentations of odontomas by collecting and analyzing the clinical, radiographic, and pathologic data of odontomas diagnosed in our institution from 2013 to 2022. Over this 10-year period, there were 242 patients with a histopathological and/or radiographic diagnosis of odontoma. There was no gender predilection and ages ranged from 3 to 101 years (median, 14 years). The second decade of life was the most prevalent (57.4%). There was no jaw predilection; however, the anterior jaw was the most common location. Ninety-four (38.8%) cases presented with clinical findings. The most common finding was tooth impaction (n = 83). Nine (3.7%) cases were histopathologically confirmed to be associated with other lesions such as dentigerous cysts (n = 8) and nasopalatine duct cyst (n = 1). The median age (25 years) of patients diagnosed with odontomas associated with cysts was older than patients with odontomas (14 years) without associated cysts. Compound odontomas were the most common type of odontoma compared to complex and AFOs with 71.4%, 26.6%, and 2%, respectively. The majority of compound odontomas involved the anterior jaw (69.3%) and mandible (54.9%) while the majority of complex odontomas involved the posterior jaw (59.6%) and maxilla (54.7%). The four AFOs were in the posterior jaw and 75% involved the maxilla. The median age (12 years) of patients diagnosed with AFO was the youngest compared to patients diagnosed with compound (13 years) and complex (16 years). In conclusion, we analyzed the clinical, radiographic, and pathologic features of 242 new cases of odontomas. Our study reaffirms that odontomas frequently affect the pediatric population and can disrupt their dentition. Based on the result of this study, our clinical recommendation to prevent problems to adjacent teeth from odontomas is for dentists to be apt in the diagnose of odontomas to ensure that they are surgically removed in a timely manner. [ABSTRACT FROM AUTHOR]

Introduction: Ameloblastic fibro-odontoma (AFO) is a benign odontogentic tumor without an aggressive behavior, unlike the similar ameloblastic fibroma. Case Presentation: A 9-year-old boy, with tooth eruption failure, underwent enucleation and curettage of a well-defined variable radiolucent and radio-opaque right mandible lesion. There was odontogenic epithelium with peripheral palisading in a loose myxoid stroma as well as a disorganized component of dentin, enamel, and cementum, features of an AFO. Conclusion: AFO is an odontogenic mixed tumor of epithelium and mesenchyme. [ABSTRACT FROM AUTHOR]

Ameloblastic fibroma (AF) and ameloblastic fibro-odontoma (AFO) are mixed odontogenic tumors (odontogenic tumors with induction) that are reported only rarely in dogs. These tumors are histologically complex and, to a degree, recapitulate the early stages of tooth development, comprising 2 types of tissue: neoplastic odontogenic epithelium, and induced ectomesenchyme (dental pulp). AFOs are distinguished from AFs by the additional presence of hard dental matrices such as dentin. Herein, we describe the key diagnostic features of AF and AFO in 4 young dogs.

An ameloblastic fibroma with formation of dental hard tissues, which the classical name is ameloblastic fibro-odontoma (AFO), is a rare type of mixed odontogenic tumor. An 8-year-old boy was diagnosed with AFO, with an inhomogeneous high signal within the lesion shown by T2-weighted magnetic resonance imaging (MRI). Computed tomography (CT) imaging revealed a unilocular low CT value area of 24 × 19 × 26 mm with buccolingual bony expansion and cortical bone thinning on the left side of the mandible including the crown of the mandibular left second molar. In addition, multiple calcified bodies were detected within the lesion, one of which had a CT value of approximately 2200 HU, equivalent to that of enamel. MRI indicated the lesion to be sized 24 × 19 × 25 mm along with buccolingual bony expansion in the left side of the mandible. Additionally, the lesion showed an internal inhomogeneous high signal, while a portion had an especially high signal in T2-weighted images. That particularly high signal area coincided with the nodular growth area of mucus-rich mesenchymal components without the epithelial component in histopathology findings. The particularly high signal revealed by T2-weighted imaging could be attributed to the mucus-rich component. MRI was found useful for revealing differences in the internal histopathological properties of an AFO in our patient. [ABSTRACT FROM AUTHOR]

Odontomas are considered hamartomatous lesions and are one of the two most common odontogenic tumors of the jaw. Odontomas are classified as compound or complex. Recently, ameloblastic fibro-odontoma (AFO) and ameloblastic fibro-dentinoma were reclassified as developing odontomas. Though clinically odontomas are usually asymptomatic, they have adverse effects on adjacent teeth such as tooth impaction, delayed eruption, displacement of teeth, over-retention of teeth, and can give rise to odontogenic cysts within the jaw. We sought to evaluate the clinicoradiopathologic presentations of odontomas by collecting and analyzing the clinical, radiographic, and pathologic data of odontomas diagnosed in our institution from 2013 to 2022. Over this 10-year period, there were 242 patients with a histopathological and/or radiographic diagnosis of odontoma. There was no gender predilection and ages ranged from 3 to 101 years (median, 14 years). The second decade of life was the most prevalent (57.4%). There was no jaw predilection; however, the anterior jaw was the most common location. Ninety-four (38.8%) cases presented with clinical findings. The most common finding was tooth impaction (n = 83). Nine (3.7%) cases were histopathologically confirmed to be associated with other lesions such as dentigerous cysts (n = 8) and nasopalatine duct cyst (n = 1). The median age (25 years) of patients diagnosed with odontomas associated with cysts was older than patients with odontomas (14 years) without associated cysts. Compound odontomas were the most common type of odontoma compared to complex and AFOs with 71.4%, 26.6%, and 2%, respectively. The majority of compound odontomas involved the anterior jaw (69.3%) and mandible (54.9%) while the majority of complex odontomas involved the posterior jaw (59.6%) and maxilla (54.7%). The four AFOs were in the posterior jaw and 75% involved the maxilla. The median age (12 years) of patients diagnosed with AFO was the youngest compared to patients diagnosed with compound (13 years) and complex (16 years). In conclusion, we analyzed the clinical, radiographic, and pathologic features of 242 new cases of odontomas. Our study reaffirms that odontomas frequently affect the pediatric population and can disrupt their dentition. Based on the result of this study, our clinical recommendation to prevent problems to adjacent teeth from odontomas is for dentists to be apt in the diagnose of odontomas to ensure that they are surgically removed in a timely manner.

The occurrence and manifestation of each ameloblastic fibro-odontoma (AFO) is quite rare and uncommon. Mentioned odontogenic tumor classification had changed over the years; however, the treatment possibilities for this lesion remain the same. In most cases surgical enucleation is sufficient enough; however, bigger lesions might require bone curettage with sometimes performed bony ostectomy, which is a quite sufficient and effective method of treatment. In the presented case report, a panoramic radiological evaluation indicated an impacted molar tooth surrounded with mixed radiolucent/radiopaque areas. The 10-year-old Caucasian girl was scheduled for an incisional biopsy. The bone cavity in the mandible after tumor removal might be left for spontaneous healing or grafting techniques, depending on the shape and size of the defect. In the presented case report, the usage of PRF/iPRF in the mandibular bone cavity, and healing improved the overall final result. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontomas (AFOs), cemento-ossifying fibromas (COFs), and giant cell granulomas (GCGs) represent mixed radiolucent/radiopaque lesions found most often in the mandible [1,2,3,4,6,7]. Though there have been reported cases documenting associations of hybrid COFs and GCGs, there have been no reported cases documenting hybrid AFOs and cemento-ossifying fibromas. The following report presents a unique case of the development of an AFO in combination with a COF and a GCG in the mandible of an 8-year-old male. This combination has not yet been described in the literature, and the purpose of this case report is to highlight the presentation of and review the clinical features and treatment recommendations for this combined lesion.

Ameloblastic fibro-odontoma is a rare tumor affecting the pediatric population and young adults. The World Health Organization (WHO) in 2005 defined it as “A neoplasm composed of proliferating odontogenic epithelium in a cellular ectomesenchymal tissue with varying degrees of inductive changes and dental hard tissue formation.” There exists a controversy on its histogenesis designating it as a hamartoma (developing complex odontoma [CO]) or a true neoplasm since both the lesions appear similar histologically. Recently, the WHO in 2017 has clubbed both these lesions as the same entity. Most cases are reported in males and in mandible, while cases in maxilla are scarce. This article describes a recurrence of a previously reported case of ameloblastic fibroma which showed maturation into AFO or CO in a girl aged 6 years in the posterior maxilla. This case is reported due to its rarity and a brief review with differential diagnosis is also discussed.

Ameloblastic fibro-odontoma (AFO) is a controversial, rare benign mixed odontogenic tumour that was re-defined as "developing odontoma" in the 2017 WHO classification arguing that once dental hard tissues form, it is programmed to transform into odontoma. However, AFO still remains unclear in terms of its nature. We aimed to analyze a large series of AFOs and compare it to a large series of odontomas (ODs) in an attempt to set cut-off diagnostic parameters between these entities and discuss latest updates on AFO histopathologic, clinical and molecular features. A total of 23 well-documented AFOs were analyzed versus 310 ODs focusing on the age of the patients and size of the lesions. For AFO, mean age was 9.4 ± 3.9 years (range 3–16 years) and mean size (greatest diameter) was 2.9 ± 1.5 cm (range 0.8–5.5 cm). For OD—mean age was 26.5 ± 15.6 years (range 3–81 years), mean size 1.9 ± 0.9 cm (range 1–5 cm). Receiver operating curve (ROC) showed that a cut-off age of 13.5 years and below [area under the curve (AUC) 0.902, 95%CI 0.859–0.945; p < 001; sensitivity 80%, specificity 87%] and a cut-off size of 2.1 cm and above are likely to be associated with AFO (AUC 0.7, 95%CI 0.574–0.827; p = 0.001; sensitivity 57%, specificity 77%). Thus, the combination of age and lesion size may be used to distinguish between lesions of a true neoplastic nature (i.e., AFO) and hamartomatous formation (i.e., OD). Further molecular and genetic specifications are needed to provide a better understanding on the pathogenesis of AFO in support of our suggestion and aid in an accurate classification of AFO. [ABSTRACT FROM AUTHOR]

Developing odontoma is a rare mixed odontogenic tumor that can arise with other odontogenic lesions. The association of COC with ameloblastic fibro‐odontoma is extremely rare. We report an extremely rare case of developing odontoma arising from a calcifying odontogenic cyst in a 17‐year‐old girl. [ABSTRACT FROM AUTHOR]

Abstract Developing odontoma is a rare mixed odontogenic tumor that can arise with other odontogenic lesions. The association of COC with ameloblastic fibro‐odontoma is extremely rare. We report an extremely rare case of developing odontoma arising from a calcifying odontogenic cyst in a 17‐year‐old girl.

The occurrence and manifestation of each ameloblastic fibro-odontoma (AFO) is quite rare and uncommon. Mentioned odontogenic tumor classification had changed over the years; however, the treatment possibilities for this lesion remain the same. In most cases surgical enucleation is sufficient enough; however, bigger lesions might require bone curettage with sometimes performed bony ostectomy, which is a quite sufficient and effective method of treatment. In the presented case report, a panoramic radiological evaluation indicated an impacted molar tooth surrounded with mixed radiolucent/radiopaque areas. The 10-year-old Caucasian girl was scheduled for an incisional biopsy. The bone cavity in the mandible after tumor removal might be left for spontaneous healing or grafting techniques, depending on the shape and size of the defect. In the presented case report, the usage of PRF/iPRF in the mandibular bone cavity, and healing improved the overall final result.

Ameloblastic fibro-odontoma is a rare tumor affecting the pediatric population and young adults. The World Health Organization (WHO) in 2005 defined it as "A neoplasm composed of proliferating odontogenic epithelium in a cellular ectomesenchymal tissue with varying degrees of inductive changes and dental hard tissue formation." There exists a controversy on its histogenesis designating it as a hamartoma (developing complex odontoma [CO]) or a true neoplasm since both the lesions appear similar histologically. Recently, the WHO in 2017 has clubbed both these lesions as the same entity. Most cases are reported in males and in mandible, while cases in maxilla are scarce. This article describes a recurrence of a previously reported case of ameloblastic fibroma which showed maturation into AFO or CO in a girl aged 6 years in the posterior maxilla. This case is reported due to its rarity and a brief review with differential diagnosis is also discussed. [ABSTRACT FROM AUTHOR]

Tumor induced osteomalacia (TIO) is a rare paraneoplastic syndrome associated with tumors secreting fibroblast growth factor 23, which induces osteomalacia. Microscopically, these tumors most commonly show benign phosphaturic mesenchymal tumors. We report the first case of phosphaturic ameloblastic fibro-odontoma (AFO) manifesting as osteomalacia. Our index patient was a 33-year-old male who was diagnosed with TIO and AFO in the mandible was identified as the cause. Our case is unique as AFO is considered as a hamartoma. To the best of our knowledge, there is no hamartoma reported till date causing phosphaturic osteomalacia. As AFO demonstrates mixed epithelial and mesenchymal origin, we propose a new histopathological subtype of TIO—"phosphaturic tumor of mixed epithelial and mesenchymal origin". A review of literature focused on TIO caused by oral lesions revealed 88 oral neoplasms which matched our search criteria. Due to the rarity and unpredictable behavior of TIOs, a high index of suspicion, a broad diagnostic approach, detailed history and multidisciplinary investigations are crucial for establishing the definitive diagnosis and proper treatment recommendations. [ABSTRACT FROM AUTHOR]

Copyright of Revista de la Asociación Odontológica Argentina is the property of Asociacion Odontologica Argentina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ameloblastic fibro-odontoma (AFO) is a mixed odontogenic tumor, which has an epithelial and mesenchymal component. It can be observed in imaging tests as a radiomixed lesion, with some authors claiming it represents only the predecessor of an odontoma. Epidemiologically, it appears between the second and third decade of life, predominantly in males and with a predilection for the posterior area of the mandible. This lesion presents a good prognosis and it responds well to enucleation by curettage with a low rate of recurrence. In the present article, two cases of ameloblastic fibro-odontoma in an unusual region of the maxilla are presented.

Introduction: Ameloblastic fibro-odontoma (AFO) is a benign complex odontogenic tumor in the mandible in children and adolescents. Observation: A 9-year-old boy was referred to the dental department for the delayed eruption of tooth 26. He was asymptomatic, and on clinical examination, we found that tooth 26 was absent with tumefaction instead of the tooth. Cone beam computed tomography revealed an opaque mass in the root of 26. The management was surgical, and anatomopathological examination facilitated the diagnosis of AFO. Commentary: The upper maxillary localization of AFO is rare and is not often a practitioner's first thought. Surgical excision of the tumor is essential based on the histological diagnosis. The patient must be followed up after 3 months and regularly until the eruption of the affected tooth. Conclusion: AFO is one of the differential diagnoses to be considered when a young patient presents with firm swelling with delayed eruption of the opposing tooth, especially since it has good prognosis and is easy to manage. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontoma (AFO) is a rare, benign, and mixed odontogenic tumor that consists of both ectodermal and mesenchymal elements. AFO is more prevalent in young children and adolescents than in adults and is usually found in the molar area associated with a failure of tooth eruption. The purpose of this report is to discuss the differential diagnosis and treatment of a three-year-old girl diagnosed with an AFO around a primary canine. The manifestations of the lesion resembled localized periodontal disease caused by an enamel pearl. Excision and curettage were done and the separated dental hard tissue was confirmed from the enamel structure of the primary canine. In addition to the hard tissue, pulpy and soft tissues were removed together and were histologically examined, confirming the diagnosis of AFO. [ABSTRACT FROM AUTHOR]

Abstract The ameloblastic fibro-odontoma is a rare benign odontogenic lesion defined as a tumor with the general features of ameloblastic fibroma but that also contains enamel and dentin. In this article the authors describe a case of a young male patient with ameloblastic fibro-odontoma of the maxilla and the management of such condition.

The ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor. Clinically AFO presents as a hamartoma or immature odontoma. The AFO is a well-encapsulated, painless, slow-growing and expanding tumor in young patients. Histologically, it has been classified as an ameloblastic fibroma or odontoma. Despite numerous efforts, there is still considerable confusion concerning the nature, the histology and the surgical therapy of this lesion. However, it can present with progressive growth causing bone destruction and significant deformity. The transformation of AFO in sarcoma is also known and extremely rare. Therefore a long term follow up is recommended. Enucleation still remains the gold standard. We are discussing our experience with AFO focused on children in clinical and surgical features and reviewing the relevant literature.

The ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor which shows properties of both ameloblastic fibroma and odontoma. It commonly affects children and young adults. In most cases, it is asymptomatic but may cause painless, slow growing swelling and discomfort. Radiologically, it is a well-circumscribed, mixed radiopaque and radiolucent entity consisting of radiolucency within which radiopaque foci of various sizes and shapes are seen. Histological examination shows both hard and soft tissue. The treatment of AFO usually conservative due to their benign biological behavior and consists of enucleation or surgical curettage. The purpose of this article is to present a case of an AFO in the posterior maxilla, along with discussion on clinical, radiological (including cone beam computed tomography scan), histological findings, and treatment of this tumor.

Introduction: According to 2017 WHO classification of odontogenic tumour, Ameloblastic Fibro-Odontoma (AFO) is no longer classified as an entity, probably representing immature stages of complex odontoma. However, there were few studies that revealed the differences between the lesion previously designated as AFO and complex odontoma. Aim: To critically analyse the clinical, radiographic features and behaviour of AFO. Materials and Methods: Eligible criteria included publications from PubMed, Scopus and Google Scholar reporting cases of AFO from 1975 to June, 2019 with available clinical, radiologic, and histologic information to confirm the diagnosis. Demographic data, localisation, size, treatment approach, follow-up period and recurrence were included. Results: Analysis of 134 cases (124 previously reported and 10 new cases). The patient’s age ranged from 7 months to 31 years (mean 10.3 years). There were 72 (54.1%) males, with a maleto-female ratio of 1.2:1. The mandible was involved in 79 (59%) cases, and the mandible-to maxilla ratio was 1.43:1. Nearly 80% of the lesions located in the posterior region of the jaws, and 48.5% were in the posterior mandible. Radiographically, most of the lesions were unilocular (95%) and only 5% were multilocular. The majority was mixed radiolucent radiopaque, and 15.8% were radiolucent. Almost all lesions (91%) were associated with the crown of an unerupted tooth. The range of follow-up was 6 months to 25 years. There were five recurrences among 134 cases accounting for a recurrence rate of 5.6%. Conclusion: According to 2017 WHO classification of odontogenic tumours, AFO was not considered as an entity and was included in odontoma. However, there are some discrepancies between AFO and odontoma especially regarding the biologic behaviour. Therefore, long term follow-up for cases previously designated as AFO is warranted.

Ameloblastic Fibrodentinoma (AFD) is an extremely rare odontogenic tumour which is a variant of Ameloblastic Fibro-Odontoma (AFO) consisting of both epithelial and connective tissue components of the dental tissue. It was first reported by Field and Ackerman in 1942 and represents less than 1% of all odontogenic tumours in most of the published literature worldwide. It generally occurs during childhood as a slow growing asymptomatic swelling in the posterior mandible. Hereby a unique case of AFD in a 35-year-old male who presented with a gradually growing painless swelling in his anterior mandible region is reported.

Introduction: According to 2017 WHO classification of odontogenic tumour, Ameloblastic Fibro-Odontoma (AFO) is no longer classified as an entity, probably representing immature stages of complex odontoma. However, there were few studies that revealed the differences between the lesion previously designated as AFO and complex odontoma. Aim: To critically analyse the clinical, radiographic features and behaviour of AFO. Materials and Methods: Eligible criteria included publications from PubMed, Scopus and Google Scholar reporting cases of AFO from 1975 to June, 2019 with available clinical, radiologic, and histologic information to confirm the diagnosis. Demographic data, localisation, size, treatment approach, follow-up period and recurrence were included. results: Analysis of 134 cases (124 previously reported and 10 new cases). The patient's age ranged from 7 months to 31 years (mean 10.3 years). There were 72 (54.1%) males, with a male- to-female ratio of 1.2:1. The mandible was involved in 79 (59%) cases, and the mandible-to maxilla ratio was 1.43:1. Nearly 80% of the lesions located in the posterior region of the jaws, and 48.5% were in the posterior mandible. Radiographically, most of the lesions were unilocular (95%) and only 5% were multilocular. The majority was mixed radiolucent radiopaque, and 15.8% were radiolucent. Almost all lesions (91%) were associated with the crown of an unerupted tooth. The range of follow-up was 6 months to 25 years. There were five recurrences among 134 cases accounting for a recurrence rate of 5.6%. conclusion: According to 2017 WHO classification of odontogenic tumours, AFO was not considered as an entity and was included in odontoma. However, there are some discrepancies between AFO and odontoma especially regarding the biologic behaviour. Therefore, long term follow-up for cases previously designated as AFO is warranted. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontoma (AFO) is a benign, epithelial odontogenic tumor with odontogenic mesenchyme having the histologic characteristics of both ameloblastic fibroma and complex odontoma. This report describes the case of a 14-year-old girl with AFO on the right posterior mandibular region that mimics complex odontoma on incisional biopsy due to the presence of atypical dentin- and cementum-like areas. On histological examination, sections of excisional biopsy showed odontogenic epithelial islands with embryonic connective tissue and decalcified sections showed atypical dentin with dentinal tubules and islands of cementum. These features led to the diagnosis of AFO. [ABSTRACT FROM AUTHOR]

Abstract Ameloblastic fibro-odontoma (AFO) is an uncommon benign tumor of the jaws and mostly found in patients aged less than 20 years. In this report, we describe two cases of AFO in a 5-year-old girl and a 3-year-old boy. In both cases, radiographic images showed a well-defined unilocular radiolucency with partial radiopacity in their jaws. Lesions were removed under general anesthesia and histopathologically examined, which revealed then to be AFOs. Although unerupted teeth that came in contact with the lesions were left as is, no recurrence was observed postoperatively. A common aspect of both cases was that a presurgical pathological diagnosis, which is usually made on the basis of findings of presurgical biopsy under local anesthesia, was not possible because of their immaturity. Differential diagnoses of AFO include calcifying epithelial odontogenic tumor (CEOT), calcifying cystic odontogenic tumor (CCOT), adenomatoid odontogenic tumor (AOT), and complex odontoma (CO). As this includes tumors with a high risk of recurrence such as CEOT, an accurate clinical diagnosis is quite important. However, it was difficult to distinguish AFO from other tumors on the basis of clinical features including radiographic findings. Our review of literature revealed that there have been no reports of cases of CEOT and CCOT in patients aged less than 6 years, whereas AFO was frequently detected. We concluded that radiographic findings in combination with the patient's age were quite useful indicators for the differential diagnosis of AFO. Moreover, our case report supported the notion that impacted teeth adjacent to AFO can be preserved. [ABSTRACT FROM AUTHOR]

Copyright of Revista de la Asociación Odontológica Argentina is the property of Asociacion Odontologica Argentina and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND AND AIM: Ameloblastic fibro-odontoma (AFO) is a rare, mixed odontogenic tumor that usually occurs in children and young adults with no gender predominance. Posterior mandibular region is usually involved and a painless swelling is the most common clinical feature. CASE REPORT: We here report a case of AFO in a 12-year-old girl with a complaint of a painful expansive lesion in the right posterior mandible. Radiographic examination showed a well-defined radiolucency containing radiopaque materials. The second molar was displaced by the lesion. Enucleation was conducted and no recurrence was observed after 4 years of follow-up. CONCLUSION: AFO is a benign expansive jaw lesion which develops in children. To treat AFO, proper surgical excision and curettage should be performed.

Ameloblastic fibro-odontoma (AFO) is an uncommon benign mixed odontogenic tumor. AFO presents as a painless swelling in the posterior of mandible or maxilla that radiographically shows a well-defined radiolucent area containing various amounts of radiopaque deposits. Most cases occur before 20 years of age, with the average age of diagnoses being 9 years. This case report describes AFO affecting anterior mandible in the 29 month old girl. The lesion was surgically excised, and no recurrence was observed on 2 month follow-up.

Ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor. It occurs predominantly in children and young adults with no sex predilection, mostly in the mandible posterior region. A painless swelling is the most common clinical sign of AFO. Radiographically, AFO shows a circumscribed radiolucency, which contains radiopaque foci of various sizes and shapes. Histological examination reveals a fibrous soft tissue, islands of odontogenic epithelium, and a disordered mixture of dental tissues. Treatment of AFOs usually consists of enucleation or surgical curettage, which is possible due to their benign biological behavior. Here, we are reporting a case of AFO in a 20-year-old male.

The ameloblastic fibro-odontoma (AFO) is a rare, mixed odontogenic tumor exhibiting the histological characters of the ameloblastic fibroma and complex odontoma. It is comprised of proliferating ectodermal and mesenchymal components of odontogenic tissue as well as enamel and dentin. AFO normally presents as an asymptomatic swelling of the posterior maxilla or mandible and is usually associated with developing teeth, occurring predominantly in children and adolescents. Such lesions are generally found upon radiographic examination of patients whose tooth eruption is delayed. This lesion often includes an unerupted permanent tooth, and extraction of this tooth is a common treatment. The purpose of this report is to describe an AFO in the posterior mandible of a nine-year-old girl for whom enucleation was performed under general anesthesia without extracting the displaced permanent mandibular left second molar. Two years later, the tooth erupted into occlusion without tumor recurrence. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontoma (AFO) is an uncommon, benign, mixed odontogenic tumour occurring predominantly in children and adolescents. The purpose of this study was to report an unusual case of AFO in the mandible of a five-year-old male patient showing evidence of chondroid tissue formation. Clinical, radiographic, histopathological and immunohistochemical findings were presented. Intraoral examination revealed a swelling extending from the right deciduous lateral incisor to the left second molar area. Computed tomography (CT) showed a large, well-demarcated multilocular radiolucency with radiopaque deposits. Histologically, the lesion was composed of connective tissue stroma resembling the dental papilla, with epithelial islands, and amorphous masses of enamel and dentin consistent with a diagnosis of AFO, as well as, evidence of large areas showing cartilaginous tissue formation. Immunohistochemistry using cytokeratin, vimentin and s-100 were helpful in determining the origin of the different odontogenic tissues. Surgical excision of the lesion was performed. The patient has been monitored and the lesion has not recurred. We report the first case of AFO showing an unusual behaviour of chondroid tissue formation. [ABSTRACT FROM AUTHOR]

Introduction: Ameloblastic fibro-odontoma is a rare, benign, asymptomatic tumor. The term ameloblastic fibro-odontoma was first used by Hooker in 1967 as a separate lesion from ameloblastic odontoma. Case Report: This case report describes an eleven years old female with large ameloblastic fibro-odontoma in the right maxillary sinus. Conclusion: There is a low potential for recurrence after complete Enucleation of ameloblastic fibro-odontoma, but due to the risk of ameloblastic sarcoma after recurrence, the surgery should be perfect along with a careful follow up.

Ameloblastic fibro-odontoma (AFO) is a benign mixed tumor of odontogenic origin. It generally occurs in children and teenagers; however, cases occurring in the elderly have also been reported. Generally, the tumor is asymptomatic and is discovered accidently on a radiograph taken for an unerupted tooth, but examples of large tumors causing jaw swelling have been reported in literature. This article presents a case of AFO causing jaw expansion with pain and lymphadenopathy in a 17-year-old male. As the final diagnosis is always confirmed by histopathology, this case is a unique one diagnosed by clinical and radiographic findings as an odontoma and suggesting the differentiation of an AFO to odontoma.

An ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor with histologic features of an ameloblastic fibroma in conjunction with the presence of dentin and enamel. It usually appears as a well-circumscribed radiolucency with radiopaque foci and slow growth and is commonly seen in children and young adults. A 13-year-old boy presented with an asymptomatic swelling in the posterior right region of the mandible and the right ascending ramus. The clinical, imaging, and histopathologic findings confirmed the diagnosis of an AFO. After 8 months, a radiolucent lesion involving the unerupted mandibular left third molar was observed; a final diagnosis of a dentigerous cyst (DC) was established for this lesion. Although coincidental events, metachronous odontogenic lesions suggest a possible common genetic origin, since both can be caused by related cellular signaling pathways. Complete enucleation is recommended for both AFOs and DCs; rates of recurrence are low. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontoma (AFO) is a rare odontogenic tumor. Initially believed to be a lesion similar to ameloblastic fibroma (AF), it is now considered as a separate entity in the WHO odontogenic tumor classification. Commonly associated with a painless swelling and an associated absence of eruption of a tooth, AFO presents as a mixed radiopaque and radiolucent lesion in the younger population with a predilection for the posterior region. Histologically, it shows the characteristics of an immature complex odontoma with irregularly arranged enamel, dentinoid, cementoid-like structures, and ectomesenchymal tissue. The following case report describes a case of AFO with a predominantly radiopaque component and briefly discusses the available literature pertaining to this rare entity. [ABSTRACT FROM AUTHOR]

Introduction: Ameloblastic fibro-odontoma (AFO) is a rare benign, slow-growing, expansile epithelial odontogenic tumor with odontogenic ectomesenchyme. It constitutes about 1 to 3% of all odontogenic tumors. This lesion usually occurs in people less than 20 years old, and thus age is an important characteristic in the differential diagnosis. Case report: An 8-year-old boy reported with a swelling in the right mandibular region. Panoramic radiograph showed a well-demarcated radiolucency containing radiopaque areas of irregular shape extending from the right deciduous second molar to the permanent third molar region. A provisional clinical diagnosis of complex odontome was made. Ameloblastic fibro-odontoma, odontoameloblastoma, calcifying epithelial odontogenic tumor, and calcifying odontogenic cyst were also included in the differential diagnoses. Management and prognosis: Patient underwent tumor excision, and histopathological examination confirmed as AFO. The patient was followed postoperatively for 12 months and no sign of recurrence was noted. Conclusion: Long-term follow-up at regular short intervals should be maintained in the management of AFO. Here we add one more case to the sparsely reported AFO with a brief review of literature. [ABSTRACT FROM AUTHOR]

Ameloblastic fibro-odontoma (AFO) is a rare benign odontogenic tumor of epithelial and ectomesenchymal origin associated with formation of mineralized products of odontogenesis. This manuscript reports an AFO affecting the posterior mandible of a 10-year-old boy with detailed clinical, radiographic and histopathological evaluation. The incisional biopsy was performed which revealed strands and islands of odontogenic epithelium composed of columnar peripheral cells surrounding central region where the cells were loosely arranged, resembling the stellate reticulum of enamel organ. The mesenchymal portion consisted of numerous ovoid and stellate cells in a loose matrix, similar to dental papilla in development. At this point, the diagnosis was ameloblastic fibroma (AF). The patient underwent complete surgical excision of the lesion associated with application of Carnoy's solution and maintenance of the first molar. The histopathological analysis established the final diagnosis of AFO, since the same histopathological characteristics of AF were observed plus enamel and dentin matrix material on close relationship with epithelial structures. Immunohistochemical panel (AE1/AE3, CK14, CK19, Vimentin, β-catenin, S-100, Ki67) was performed to illustrate AFO features. Treatment of odontogenic tumors is based on the biological and clinical behavior. In general, prognosis is excellent, with rare recurrence reports and even rarer reports of malignant transformation. No recurrence or signs of other tumors have been observed in the patient for 1 year after tumor resection. [ABSTRACT FROM AUTHOR]

Ameloblastic Fibrodentinoma (AFD) is an extremely rare odontogenic tumour which is a variant of Ameloblastic Fibro-Odontoma (AFO) consisting of both epithelial and connective tissue components of the dental tissue. It was first reported by Field and Ackerman in 1942 and represents less than 1% of all odontogenic tumours in most of the published literature worldwide. It generally occurs during childhood as a slow growing asymptomatic swelling in the posterior mandible. Hereby a unique case of AFD in a 35-year-old male who presented with a gradually growing painless swelling in his anterior mandible region is reported. [ABSTRACT FROM AUTHOR]

Odontoameloblastoma are tumours which represent a histological combination of ameloblastoma and complex odontoma. It behaves in an invasive manner like ameloblastoma and is more aggressive in nature. We report a new case of Ameloblastic Fibro-Odontoma (AFO). Clinical, radiographic and histopathological features are discussed.

The occurrence of ameloblastic fibro-odontoma (AFO) in the oral region is unusual and accounts for 1-3% of all odontogenic tumors. AFO presents mixed radiopaque patterns within the lesion with diverse findings; therefore, it is important to compare this tumor with other odontogenic tumors that radiographically present with calcified bodies. Herein, we observed the calcification patterns within the lesion in seven AFO cases (five males, two females; mean age, 8.3 years; age range, 4-13 years). Periapical and panoramic radiographs were obtained from all seven cases. Five cases underwent conventional computed tomography (CT) scanning, and one underwent cone beam CT. Classification of the calcifications primarily involved the following two characteristics on the X-rays: appearance and location of the lesions. All seven cases were located in the molar regions of the mandible in association with impacted teeth. The calcification patterns of these AFOs were mixed or inhomogeneous within the lesion with various findings, including complex odontoma-like calcifications. However, the patterns differed between panoramic radiography and CT in some cases. The radiolucent lesions in AFO demonstrated varying calcification patterns and were associated with impacted teeth on the CT images.(J Oral Sci 58, 533-537, 2016). [ABSTRACT FROM AUTHOR]

Introduction: Ameloblastic fibro-odontoma (AFO) is defined as a benign odontogenic tumor with slow growing behavior. Its prevalence is rare. AFO is characterized by histologic features of ameloblastic fibroma (AF) with the formation of enamel and dentine. Case Presentation: This is a case report of AFO accompanied with a number of impacted deciduous teeth and its management in a 4-year old boy. Examination of oral cavity revealed an extensive swelling from midline to left deciduous maxillary first molar, covered with normal mucosa. Radiographic examination showed a well-defined mixed radiolucent-radiopaque lesion that extended horizontally from midline to mesial border of the left maxillary primary first molar and vertically from alveolar crest to the floor of nose. The differential diagnosis was odontoma (ameloblastic fibro-odontoma, complex odontoma). Surgical enucleation and curettage was performed under general anesthesia. Histopathologic sections show bone trabeculae in marrow spaces. There was myxoid matrix in some spaces which contained odontogenic epithelial cells. These findings led to diagnosis of AFO. No sign of recurrence has been observed during the 12-month followup period. Conclusion: Although AFO is a rare tumor, it is more prevalent in childrenʼs jaw. Conservative surgical treatment allowed the normal development of teeth. [ABSTRACT FROM AUTHOR]