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Depending on the age and location within the skeleton, bone marrow can be mostly fatty or hematopoietic, and both types can be affected by marrow necrosis. This review article highlights the magnetic resonance imaging findings of disorders in which marrow necrosis is the dominant feature. Fatty marrow necrosis is detected on T1-weighted images that show an early and specific finding: the reactive interface. Collapse is a frequent complication of epiphyseal necrosis and detected on fat-suppressed fluid-sensitive sequences or using conventional radiographs. Nonfatty marrow necrosis is less frequently diagnosed. It is poorly visible on T1-weighted images, and it is detected on fat-suppressed fluid-sensitive images or by the lack of enhancement after contrast injection. Pathologies historically "misnamed" as osteonecrosis but do not share the same histologic or imaging features of marrow necrosis are also highlighted. [ABSTRACT FROM AUTHOR]

Aim: To assess the frequency of bone changes in resected osteonecrotic femoral head (ONFH) specimens at multidetector computed tomography (MDCT) and compare their frequencies between ONFH with limited or advanced collapse. Method: Fourteen ONFH were imaged using MDCT (n = 14) and microcomputed tomography ([µCT]; n = 8). Preoperative staging was performed using radiographs and MRI. Coronal reformats of MDCT images of the specimens were analyzed using the grid overlay method. There were 2,933 grid boxes containing cortical bone and 10,596 containing trabecular bone. Two MSK radiologists assessed in every grid box the presence of interface-related sclerosis, cortical bone interruption, trabecular bone interruption, and trabecular bone resorption. The frequency of grid boxes with bone changes at MDCT was calculated and compared between ONFH with limited (

To assess the topology of bone and cartilage microfractures in osteonecrotic femoral heads. Sixteen resected human femoral heads with collapsed osteonecrosis (ON, n = 11) or osteoarthritis (OA, n = 5) were imaged at μCT with 12 μ nominal resolution. Forty-seven histological sections and μCT reformats with (n = 30) or without (8 from ON and 9 from OA femoral heads) osteonecrotic lesions were obtained and divided in 2 × 2 mm segments by a superposed grid. A radiologist and a pathologist separately assessed the presence of bone and cartilage microfractures in each segment on μCT and histological images, respectively. We determined the frequency and distribution of segments with bone microfractures according to a zonal distribution. Matrix analysis was performed by using Matlab to calculate the connectivity index and long/short axis ratios of clustered segments with microfractures. Segments with bone microfractures but not with cartilage microfractures were found more frequently in ON than in OA femoral heads. In the 38 matched μCT and histological images from ON femoral heads, 86%/82% of segments with cortical microfracture, 91%/96% of segments with trabecular microfractures involved ON lesions at μCT/histology. At histology, 83% of segments with cartilage microfractures involved ON lesions. In the 30 paired μCT and histological images containing necrotic lesions, the frequency of segments with trabecular microfractures in the superficial layers (55% at μCT/51% at histology) was statistically significantly higher than in the deep layer (25% P < 0.0001/35%; P = 0.0006). Clustered segments with cortical/trabecular microfractures, exclusively found in osteonecrotic lesions, had a connectivity index >2.0/20.0 and mean long/short axis ratio > 2.35/2.2, respectively. Segments with bone microfractures predominate in necrotic lesions. Segments with trabecular microfractures form elongated clusters near the femoral head surface. Unlabelled Image • Cortical and trabecular bone microfractures are frequent in collapsed ON femoral heads and are ubiquitous. • Trabecular microfractures predominate in the superficial layer of the epiphysis and form elongated clusters. • Microfractures in viable areas of ON and OA femoral heads are scattered and do not form clusters. [ABSTRACT FROM AUTHOR]