ntroduction: Purple cabbage contains the compounds α-carotene, β-carotene, α-tocopherol, γ-tocopherol, and ascorbic acid. Apart from that, there are very high levels of vitamins A and C, anthocyanin, quercetin, kaempferol, and lutein. It has been reported to have antioxidant, anti-inflammatory, and antihypertensive activities. However, purple cabbage has not been studied as an antihypertensive that inhibits the eNOS enzyme, which triggers high blood pressure. This study aims to determine the effectiveness of compounds from purple cabbage as antihypertensives and pharmacokinetic predictions. Methods: Prediction of constituents' interactions from purple cabbage with eNOS enzyme using AutoDock Tools 1.5.6. Then, the potency of constituents based on molecular docking was tested for pharmacokinetic properties with the pkCSM ADMET descriptors algorithm protocol. Results: In silico molecular docking, results show that β-carotene, lutein, and α-carotene (carotenoid group), as well as cyanidin-3-diglucoside-5-glucoside (anthocyanin group), have very high binding affinities with ΔG (kcal/mol) and Ki values (nM), -9.91; 54.21, -8.40; 695.27, -7.94; 1510, and -7.85; 1770, respectively compared to captopril (-4.02; 1130000) as a drug. This is because the purple color caused by this group of compounds is helpful for therapeutic effects, such as degenerative diseases. Apart from that, a group of vitamins (vitamin A, α- and γ-tocopherol) as well as polyphenols (kaemferol) and flavonoids (quercetin). ADMET predictions show that only α-carotene and vitamin A meet the predictions of absorption (Caco2, 1.262 and 1.516 × 10-6 cm/s and intestinal absorption, 92.061 and 92.218%), distribution (BBB permeability, 0.945; 0.644), metabolism (cytochrome P450), excretion (total clearance, 1,531 log mL/min/kg vitamin A only), and toxicity (vitamin A that is not toxic in AMES test). Conclusion: The carotenoid and vitamin group from purple cabbage have the potential to be antihypertensive. [ABSTRACT FROM AUTHOR]