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Your search keyword '"van Delft, Joost"' showing total 256 results
Start Over Author "van Delft, Joost" Publication Type Academic Journals
256 results on '"van Delft, Joost"'

1. Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM-ICCVAM/NICEATM Considerations for Regulatory Use

Author

Corvi, Raffaella, Ahr, Hans-Jürgen, Albertini, Silvio, Blakey, David H., Clerici, Libero, Coecke, Sandra, Douglas, George R., Gribaldo, Laura, Groten, John P., Haase, Bernd, Hamernik, Karen, Hartung, Thomas, Inoue, Tohru, Indans, Ian, Maurici, Daniela, Orphanides, George, Rembges, Diana, Sansone, Susanna-Assunta, Snape, Jason R., Toda, Eisaku, Tong, Weida, van Delft, Joost H., Weis, Brenda, and Schechtman, Leonard M.

Published
2006

16. Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

Author

Adler, Sarah, Basketter, David, Creton, Stuart, Pelkonen, Olavi, van Benthem, Jan, Zuang, Valérie, Andersen, Klaus Ejner, Angers-Loustau, Alexandre, Aptula, Aynur, Bal-Price, Anna, Benfenati, Emilio, Bernauer, Ulrike, Bessems, Jos, Bois, Frederic Y., Boobis, Alan, Brandon, Esther, Bremer, Susanne, Broschard, Thomas, Casati, Silvia, Coecke, Sandra, Corvi, Raffaella, Cronin, Mark, Daston, George, Dekant, Wolfgang, Felter, Susan, Grignard, Elise, Gundert-Remy, Ursula, Heinonen, Tuula, Kimber, Ian, Kleinjans, Jos, Komulainen, Hannu, Kreiling, Reinhard, Kreysa, Joachim, Leite, Sofia Batista, Loizou, George, Maxwell, Gavin, Mazzatorta, Paolo, Munn, Sharon, Pfuhler, Stefan, Phrakonkham, Pascal, Piersma, Aldert, Poth, Albrecht, Prieto, Pilar, Repetto, Guillermo, Rogiers, Vera, Schoeters, Greet, Schwarz, Michael, Serafimova, Rositsa, Tähti, Hanna, Testai, Emanuela, van Delft, Joost, van Loveren, Henk, Vinken, Mathieu, Worth, Andrew, and Zaldivar, José-Manuel

Published
2011
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20. Vegetables affect the expression of genes involved in carcinogenic and anticarcinogenic processes in the lungs of female C57BI/6 mice

Author

van Breda, Simone G., van Agen, Ebienus, van Sanden, Suzy, Burzykowski, Tomasz, Kleinjans, Jos C., and van Delft, Joost H.

Subjects
Carcinogens -- Research, Cocarcinogens -- Research, Lungs -- Research, Vegetables -- Chemical properties, Food/cooking/nutrition
Abstract

Worldwide, lung cancer is the most prevalent and lethal malignant disease. In addition to avoidance of the most predominant risk factor, i.e., tobacco use, consumption of high amounts of vegetables and fruits could be an effective means of preventing lung cancer. However, the molecular mechanisms underlying lung cancer risk reduction by vegetables are not clear. In the present study, the effect of vegetables on gene expression changes in the lungs of female C57BI/6 mice was investigated using cDNA microarray technology. The mice were fed 1 of 8 diets for 2 wk: a control diet containing no vegetables (diet 1); a diet containing a vegetable mixture at 100 (diet 2, 10% dose), 200 (diet 3, 20% dose), or 400 (diet 4, 40% dose) g/kg; or a diet containing cauliflower at 70 (diet 5, 7% dose); carrots at 73 (diet 6, 7.3% dose); peas at 226 (diet 7, 22.6% dose); or onions at 31 (diet 8, 3.1% dose) g/kg. The vegetable mixture consisted of these 4 individual vegetables. After the mice were killed, the lungs were removed and total RNA was isolated from the lungs for expression analysis of 602 genes involved in pathways of (anti)-carcinogenesis. The results of this study suggest that individual vegetables have a higher potential of modulating genes (5 from the 8 modulated genes) in favor of lung cancer risk prevention, in comparison with the vegetable mixture (2 from the 7 modulated genes); the other gene modulations are expected to enhance lung cancer risk. The pathways involved were miscellaneous and included cell growth, apoptosis, biotransformation, and immune response. Furthermore, carrots were able to modulate most gene expressions, and most of these effects occurred in processes that favored lung cancer risk prevention. The current study provides more insight into the genetic mechanisms by which vegetables, in particular carrots, can prevent lung cancer risk. KEY WORDS: * vegetables * microarrays * gene expression * C57BI/6 mice * lung

Published
2005

21. Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BI/6 female mice

Author

van Breda, Simone G.J., van Agen, Ebienus, van Sanden, Suzy, Burzykowski, Tomasz, Kienhuis, Anne S., Kleinjans, Jos C.S., and van Delft, Joost H.M.

Subjects
Food/cooking/nutrition
Abstract

There is abundant epidemiological evidence that vegetable consumption decreases colorectal cancer (CRC) risk. However, the molecular targets in the genome are mostly unknown. The present study investigated the effects of vegetable consumption on gene expression in the colon mucosa of female C57BI/6 mice using cDNA microarray technology. Mice were fed one of 8 diets: a control diet containing no vegetables (diet 1); a diet containing 100 g/kg (diet 2, 10% dose), 200 g/kg (diet 3, 20% dose), or 400 g/kg (diet 4, 40% dose) of a vegetable mixture; or a diet containing 70 g/kg of cauliflower (diet 5, 7% dose), 73 g/kg of carrots (diet 6, 7.3% dose), 226 g/kg of peas (diet 7, 22.6% dose); or 31 g/kg of onions (diet 8, 3.1% dose). The vegetable mixture used in diets 2 to 4 consisted of the 4 individual vegetables used in diets 5 to 8: cauliflower (30% wet wt), carrots (30% wet wt), peas (30% wet wt), and onions (10% wet wt). To assess gene expression changes, colonic mucosal cells were collected after the mice were killed. Total RNA was isolated and microarray technology was used to measure the expression levels of 602 genes simultaneously. For 39 genes, significant dose-dependent effects were found, although in general the relations were not linear. For 15 genes, the altered expression could indeed explain reduced cancer risk at various stages of CRC development. Eleven genes were modulated by the vegetable mixture as well as by one or more of the individual vegetables. For 7 of the genes, the modulation by the mixture was due to the effect of a particular vegetable. These genes are of particular interest because they were consistently affected and could be involved in the prevention of CRC by vegetable consumption. J. Nutr. 135: 1879-1888, 2005. KEY WORDS: * vegetables * microarrays * gene expression * C57BI/6 mice * colon

Published
2005

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