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Start Over Author "van den Berg, L." Publication Type Academic Journals
815 results on '"van den Berg, L."'

3. Theme 02 - Genetics and Genomics.

Author

Baindoor, S., Gibriel, H., Donovan, P., Veno, M., Kjems, J., van den Berg, L., van Es, M., Prehn, J., Biasetti, L., Troakes, C., King, A., Smith, B., Grant, O., Gromicho, M., Simão, S., Pronto-Laborinho, A., Oliveira Santos, M., De Carvalho, M., Domínguez-Rubio, R., and Lombardo, P.

Subjects
AMYOTROPHIC lateral sclerosis, GENETICS, GENOMICS, RESEARCH personnel
Abstract

The text is a list of authors who have contributed to an article titled "Theme 02 - Genetics and Genomics" in the journal "Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration." The article likely discusses the role of genetics and genomics in the development and progression of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). The list of authors is extensive and includes researchers from various institutions and countries, indicating a diverse range of perspectives and expertise in the field. [Extracted from the article]

Published
2023
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6. Diagnostic accuracy of nerve excitability and compound muscle action potential scan derived biomarkers in amyotrophic lateral sclerosis.

Author

Stikvoort García, D. J. L., Sleutjes, B.T.H.M., van Schelven, L. J., Goedee, H. S., and van den Berg, L. H.

Subjects
AMYOTROPHIC lateral sclerosis, ACTION potentials, SPINAL muscular atrophy, MOTOR unit, MOTOR neuron diseases, NERVES, RILUZOLE
Abstract

Background and purpose: The lack of reliable early biomarkers still causes substantial diagnostic delays in amyotrophic lateral sclerosis (ALS). The aim was to assess the diagnostic accuracy of a novel electrophysiological protocol in patients with suspected motor neuron disease (MND). Methods: Consecutive patients with suspected MND were prospectively recruited at our tertiary referral centre for MND in Utrecht, The Netherlands. Procedures were performed in accordance with the Standards for Reporting of Diagnostic Accuracy. In addition to the standard diagnostic workup, an electrophysiological protocol of compound muscle action potential (CMAP) scans and nerve excitability tests was performed on patients' thenar muscles. The combined diagnostic yield of nerve excitability and CMAP scan based motor unit number estimation was compared to the Awaji and Gold Coast criteria and their added value was determined. Results: In all, 153 ALS or progressive muscular atrophy patients, 63 disease controls and 43 healthy controls were included. Our electrophysiological protocol had high diagnostic accuracy (area under the curve [AUC] 0.85, 95% confidence interval [95% CI] 0.80–0.90), even in muscles with undetectable axon loss (AUC 0.78, 95% CI 0.70–0.85) and in bulbar‐onset patients (AUC 0.85, 95% CI 0.73–0.95). Twenty‐four of 33 (73%) ALS patients who could not be diagnosed during the same visit were correctly identified, as well as 8/13 (62%) ALS patients not meeting the Gold Coast criteria and 49/59 (83%) ALS patients not meeting the Awaji criteria during this first visit. Conclusions: Our practical and non‐invasive electrophysiological protocol may improve early diagnosis in clinically challenging patients with suspected ALS. Routine incorporation may boost early diagnosis, enhance patient selection and generate baseline measures for clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Physical training and high‐protein diet improved muscle strength, parent‐reported fatigue, and physical quality of life in children with Pompe disease.

Author

Scheffers, L. E., Somers, O. C., Dulfer, K., Dieleman, G. C., Walet, S., van der Giessen, L. J., van der Ploeg, A. T., van den Hout, J. M. P., and van den Berg, L. E.

Abstract

Exercise has proven to be an effective adjuvant treatment to enzyme replacement therapy (ERT) in mildly affected adult Pompe patients. The aim of this study was to investigate the effects of a 12‐week tailored lifestyle intervention, consisting of physical training and a high protein diet (2 grams/kg), in children with Pompe disease. This randomized controlled semi‐crossover trial investigated the effects of a lifestyle intervention on the primary outcome: exercise capacity. Secondary outcomes were: muscle strength, core stability, motor function, physical activity levels, quality of life, fatigue, fear of exercise, caloric intake, energy balance, body composition, and safety. Fourteen Pompe patients with a median age of 10.6 [IQR: 7.2–14.5], of whom six classic infantile patients, participated in the lifestyle intervention. At baseline, patients had a lower exercise capacity compared to healthy peers (median 70.3% [IQR: 54.8%–98.6%] of predicted). After the intervention, absolute Peak VO2 improved significantly (1279 mL/min [1012.5–2006] vs. 1352 mL/min [1101.5–2069], p = 0.039), but not compared to the control period. Muscle strength of the hip flexors, hip abductors, elbow extensors, neck extensors, knee extensors, and core stability improved significantly compared to the control period. Children reported a significant increase on the change in health domain of quality of life, parents reported significantly better scores on the quality of life domains: physical functioning, change in health, family cohesion, and fatigue. A 12‐week tailored lifestyle intervention for children with Pompe disease seemed safe and led to improvements in muscle strength, core stability, quality of life, and parent‐reported fatigue. Pompe patients with a stable disease trajectory seemed to benefit the most from the intervention. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Climatic modifiers of the response to nitrogen deposition in peat-forming Sphagnum mosses: a meta-analysis

Author

Limpens, J., Granath, G., Gunnarsson, U., Aerts, R., Bayley, S., Bragazza, L., Bubier, J., Buttler, A., van den Berg, L. J. L., Francez, A-J., Gerdol, R., Grosvernier, P., Heijmans, M. M. P. D., Hoosbeek, M. R., Hotes, S., Ilomets, M., Leith, I., Mitchell, E. A. D., Moore, T., Nilsson, M. B., Nordbakken, J-F., Rochefort, L., Rydin, H., Sheppard, L. J., Thormann, M., Wiedermann, M. M., Williams, B. L., and Xu, B.

Published
2011

16. Common variant at 16p11.2 conferring risk of psychosis

Author

Steinberg, S, de Jong, S, Mattheisen, M, Costas, J, Demontis, D, Jamain, S, Pietiläinen, O P H, Lin, K, Papiol, S, Huttenlocher, J, Sigurdsson, E, Vassos, E, Giegling, I, Breuer, R, Fraser, G, Walker, N, Melle, I, Djurovic, S, Agartz, I, Tuulio-Henriksson, A, Suvisaari, J, Lönnqvist, J, Paunio, T, Olsen, L, Hansen, T, Ingason, A, Pirinen, M, Strengman, E, Hougaard, D M, Ørntoft, T, Didriksen, M, Hollegaard, M V, Nordentoft, M, Abramova, L, Kaleda, V, Arrojo, M, Sanjuán, J, Arango, C, Etain, B, Bellivier, F, Méary, A, Schürhoff, F, Szoke, A, Ribolsi, M, Magni, V, Siracusano, A, Sperling, S, Rossner, M, Christiansen, C, Kiemeney, L A, Franke, B, van den Berg, L H, Veldink, J, Curran, S, Bolton, P, Poot, M, Staal, W, Rehnstrom, K, Kilpinen, H, Freitag, C M, Meyer, J, Magnusson, P, Saemundsen, E, Martsenkovsky, I, Bikshaieva, I, Martsenkovska, I, Vashchenko, O, Raleva, M, Paketchieva, K, Stefanovski, B, Durmishi, N, Pejovic Milovancevic, M, Lecic Tosevski, D, Silagadze, T, Naneishvili, N, Mikeladze, N, Surguladze, S, Vincent, J B, Farmer, A, Mitchell, P B, Wright, A, Schofield, P R, Fullerton, J M, Montgomery, G W, Martin, N G, Rubino, I A, van Winkel, R, Kenis, G, De Hert, M, Réthelyi, J M, Bitter, I, Terenius, L, Jönsson, E G, Bakker, S, van Os, J, Jablensky, A, Leboyer, M, Bramon, E, Powell, J, Murray, R, Corvin, A, Gill, M, Morris, D, O'Neill, F A, Kendler, K, Riley, B, Craddock, N, Owen, M J, O'Donovan, M C, Thorsteinsdottir, U, Kong, A, Ehrenreich, H, Carracedo, A, Golimbet, V, Andreassen, O A, Børglum, A D, Mors, O, Mortensen, P B, Werge, T, Ophoff, R A, Nöthen, M M, Rietschel, M, Cichon, S, Ruggeri, M, Tosato, S, Palotie, A, St Clair, D, Rujescu, D, Collier, D A, Stefansson, H, and Stefansson, K

Published
2014
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18. Comparing the NIS vs. MRC and INCAT sensory scale through Rasch analyses

Author

Draak, Thomas H. P., Vanhoutte, Els K., van Nes, Sonja I., Gorson, Kenneth C., Van der Pol, W.-Ludo, Notermans, Nicolette C., Nobile-Orazio, Eduardo, Lewis, Richard A., Léger, Jean-Marc, Van den Bergh, Peter Y. K., Lauria, Giuseppe, Bril, Vera, Katzberg, Hans, Lunn, Michael P. T., Pouget, Jean, van der Kooi, Anneke J., Hahn, Angelika F., van den Berg, Leonard H., van Doorn, Pieter A., Cornblath, David R., Faber, Catharina G., Merkies, Ingemar S. J., Barreira, A. A., Bennett, D., Hadden, R. D., Hughes, R. A.C., Lunn, M. P.T., Reilly, M. M., van den Berg, L. H., van Doorn, P. A., Faber, C. G., van der Kooi, A. J., Merkies, I. S.J., Notermans, N. C., Raaphorts, J., van Schaik, I. N., de Visser, M., Cats, E. A., Van den Bergh, P. Y.K., Bombelli, F., Costa, R., Franques, J., Léger, J-M., Pouget, J., Bril, V., Hahn, A. F., Katzberg, H., Campanella, A., Devigili, G., Gallia, F., Lauria, G., Nobile-Orazio, E., Padua, L., Cornblath, D. R., Gorson, K. C., Lewis, R. A., Illa, I, Querol, L., and van Nes, S. I.

Published
2015
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19. Grip strength comparison in immune-mediated neuropathies: Vigorimeter vs. Jamar

Author

Draak, Thomas H. P., Pruppers, Mariëlle H. J., van Nes, Sonja I., Vanhoutte, Els K., Bakkers, Mayienne, Gorson, Kenneth C., Van der Pol, W.-Ludo, Lewis, Richard. A., Notermans, Nicolette C., Nobile-Orazio, Eduardo, Léger, Jean-Marc, Van den Bergh, Peter Y. K., Lauria, Giuseppe, Bril, Vera, Katzberg, Hans, Lunn, Michael P. T., Pouget, Jean, van der Kooi, Anneke J., van den Berg, Leonard H., van Doorn, Pieter A., Cornblath, David R., Hahn, Angelika F., Faber, Catharina G., Merkies, Ingemar S. J., Barreira, A. A., Bennett, D., Hadden, R. D., Hughes, R. A.C., Lunn, M. P.T., Reilly, M. M., van den Berg, L. H., van Doorn, P. A., Faber, C. G., van der Kooi, A. J., Merkies, I. S.J., Notermans, N. C., Raaphorts, J., van Schaik, I. N., de Visser, M., Cats, E. A., Van den Bergh, P. Y.K., Bombelli, F., Costa, R., Franques, J., Léger, J-M., Pouget, J., Bril, V., Hahn, A. F., Katzberg, H., Campanella, A., Devigili, G., Gallia, F., Lauria, G., Nobile-Orazio, E., Padua, L., Cornblath, D. R., Gorson, K. C., Lewis, R. A., Illa, I, Querol, L., and van Nes, S. I.

Published
2015
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20. Outcome measures in MMN revisited: further improvement needed

Author

Pruppers, Mariëlle H. J., Draak, Thomas H. P., Vanhoutte, Els K., Van der Pol, W-Ludo, Gorson, Kenneth C., Léger, Jean-Marc, Nobile-Orazio, Eduardo, Lewis, Richard. A., van den Berg, Leonard H., Faber, Catharina G., Merkies, Ingemar S. J., Barreira, A. A., Bennett, D., Hadden, R. D., Hughes, R. A.C., Lunn, M. P.T., Reilly, M. M., van den Berg, L. H., van Doorn, P. A., Faber, C. G., van der Kooi, A. J., Merkies, I. S.J., Notermans, N. C., Raaphorts, J., van Schaik, I. N., de Visser, M., Cats, E. A., Van den Bergh, P. Y.K., Bombelli, F., Costa, R., Franques, J., Léger, J-M., Pouget, J., Bril, V., Hahn, A. F., Katzberg, H., Campanella, A., Devigili, G., Gallia, F., Lauria, G., Nobile-Orazio, E., Padua, L., Cornblath, D. R., Gorson, K. C., Lewis, R. A., Illa, I, Querol, L., and van Nes, S. I.

Published
2015
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21. Impairment measures versus inflammatory RODS in GBS and CIDP: a responsiveness comparison

Author

Vanhoutte, Els K., Draak, Thomas H. P., Gorson, Kenneth C., van Nes, Sonja I., Hoeijmakers, Janneke G. J., Van der Pol, W.-Ludo, Notermans, Nicolette. C., Lewis, Richard A., Nobile-Orazio, Eduardo, Léger, Jean-Marc, Van den Bergh, Peter Y. K., Lauria, Giuseppe, Bril, Vera, Katzberg, Hans, Lunn, Michael P. T., Pouget, Jean, van der Kooi, Anneke J., Hahn, Angelika F., van Doorn, Pieter A., Cornblath, David R., van den Berg, Leonard H., Faber, Catharina G., Merkies, Ingemar S. J., Barreira, A. A., Bennett, D., Hadden, R. D., Hughes, R. A.C., Lunn, M. P.T., Reilly, M. M., van den Berg, L. H., van Doorn, P. A., Faber, C. G., van der Kooi, A. J., Merkies, I. S.J., Notermans, N. C., Raaphorts, J., van Schaik, I. N., de Visser, M., Cats, E. A., Van den Bergh, P. Y.K., Bombelli, F., Costa, R., Franques, J., Léger, J-M., Pouget, J., Bril, V., Hahn, A. F., Katzberg, H., Campanella, A., Devigili, G., Gallia, F., Lauria, G., Nobile-Orazio, E., Padua, L., Cornblath, D. R., Gorson, K. C., Lewis, R. A., Illa, I, Querol, L., and van Nes, S. I.

Published
2015
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22. Rasch-ionale for neurologists

Author

Vanhoutte, Els K., Hermans, Mieke C. E., Faber, Catharina G., Gorson, Kenneth C., Merkies, Ingemar S. J., Thonnard, Jean-L., Barreira, A. A., Bennett, D., Hadden, R. D., Hughes, R. A.C., Lunn, M. P.T., Reilly, M. M., van den Berg, L. H., van Doorn, P. A., Faber, C. G., van der Kooi, A. J., Merkies, I. S.J., Notermans, N. C., Raaphorts, J., van Schaik, I. N., de Visser, M., Cats, E. A., Van den Bergh, P. Y.K., Bombelli, F., Costa, R., Franques, J., Léger, J-M., Pouget, J., Bril, V., Hahn, A. F., Katzberg, H., Campanella, A., Devigili, G., Gallia, F., Lauria, G., Nobile-Orazio, E., Padua, L., Cornblath, D. R., Gorson, K. C., Lewis, R. A., Illa, I, Querol, L., and van Nes, S. I.

Published
2015
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23. Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS©)

Author

Vanhoutte, Els K., Faber, Catharina G., van Nes, Sonja I., Cats, Elisabeth A., Van der Pol, W.-Ludo, Gorson, Kenneth C., van Doorn, Pieter A., Cornblath, David R., van den Berg, Leonard H., Merkies, Ingemar S. J., Barreira, A. A., Bennett, D., Hadden, R. D., Hughes, R. A.C., Lunn, M. P.T., Reilly, M. M., van den Berg, L. H., van Doorn, P. A., Faber, C. G., van der Kooi, A. J., Merkies, I. S.J., Notermans, N. C., Raaphorts, J., van Schaik, I. N., de Visser, M., Cats, E. A., Van den Bergh, P. Y.K., Bombelli, F., Costa, R., Franques, J., Léger, J-M., Pouget, J., Bril, V., Hahn, A. F., Katzberg, H., Campanella, A., Devigili, G., Gallia, F., Lauria, G., Nobile-Orazio, E., Padua, L., Cornblath, D. R., Gorson, K. C., Lewis, R. A., Illa, I, Querol, L., and van Nes, S. I.

Published
2015
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38. Composite endpoint for ALS clinical trials based on patient preference: Patient-Ranked Order of Function (PROOF).

Author

van Eijk, Ruben P. A., van den Berg, L. H., Ying Lu, and Lu, Ying

Subjects
RESEARCH, RESEARCH methodology, PATIENT satisfaction, EVALUATION research, COMPARATIVE studies, AMYOTROPHIC lateral sclerosis, RESEARCH funding
Abstract

Background: Patients with amyotrophic lateral sclerosis (ALS) show considerable variation in symptoms. Treatments targeting an overall improvement in symptomatology may not address what the majority of patients consider to be most important. Here, we propose a composite endpoint for ALS clinical trials that weighs the improvement in symptoms compared with what the patient population actually wants.Methods: An online questionnaire was sent out to a population-based registry in The Netherlands. Patients with ALS were asked to score functional domains with a validated self-reported questionnaire, and rank the order of importance of each domain. This information was used to estimate variability in patient preferences and to develop the Patient-Ranked Order of Function (PROOF) endpoint.Results: There was extensive variability in patient preferences among the 433 responders. The majority of the patients (62.1%) preferred to prioritise certain symptoms over others when evaluating treatments. The PROOF endpoint was established by comparing each patient in the treatment arm to each patient in the placebo arm, based on their preferred order of functional domains. PROOF averages all pairwise comparisons, and reflects the probability that a patient receiving treatment has a better outcome on domains that are most important to them, compared with a patient receiving placebo. By means of simulation we illustrate how incorporating patient preference may upgrade or downgrade trial results.Conclusions: The PROOF endpoint provides a balanced patient-focused analysis of the improvement in function and may help to refine the risk-benefit assessment of new treatments for ALS. [ABSTRACT FROM AUTHOR]

Published
2022
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