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Your search keyword '"De, S."' showing total 2 results
2 results on '"De, S."'

1. Histopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole/nitazoxanide combination.

Author

Sampaio GA, Zago LV, de Lima NF, Picanço GA, Lino Júnior RS, and Vinaud MC

Subjects
Animals, Disease Models, Animal, Drug Combinations, Female, Mice, Mice, Inbred BALB C, Neurocysticercosis pathology, Nitro Compounds, Albendazole pharmacology, Anticestodal Agents pharmacology, Neurocysticercosis prevention & control, Taenia drug effects, Thiazoles pharmacology
Abstract

Neurocysticercosis (NCC) is the most common helminthic brain infection related to epilepsy. Only albendazole (ABZ) and praziquantel are used in its treatment. The development of new therapeutics has been encouraged. Taenia crassiceps cysticerci intracranial infection is the experimental model used in NCC studies. This study evaluated the histopathology of the brains of BALB/c mice experimentally infected with T. crassiceps cysticerci after the treatment with the ABZ/nitazoxanide (NTZ) combination. Thirty days after the inoculation the mice received an oral single dose of the ABZ/NTZ combination (40 mg kg-1 each). The control groups were treated with: NaCl 0.9%; ABZ or NTZ. The histopathologic evaluation of the brains was performed 24 h after treatment. The ABZ treatment induced discrete mononuclear inflammatory infiltration, meningitis, gliosis, hyperaemia and hippocampus compression; moderate ependimitis and oedema. The NTZ treatment induced accentuated inflammatory infiltration, foamy macrophages, ependimitis, choroiditis, gliosis and hyperaemia and moderate oedema. The ABZ/NTZ combination treatment induced a significant decrease in the polymorphonuclear inflammatory infiltration, ependimitis, choroiditis, gliosis, hyperaemia and ventriculomegaly in comparison with the other groups. The cysticerci showed destruction of the tegument not observed in other groups. The ABZ/NTZ combination is efficient as the parasite showed signs of destruction and lower damage to the host's tissue.

Published
2020
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2. Ecchymoses: an unusual manifestation of toxocariasis in children

Author

S. P. Lamabadusuriya, M. de S. Wijesundera, and Vithanage Pujitha Wickramasinghe

Subjects
Male, Pediatrics, medicine.medical_specialty, Ecchymosis, Mebendazole, Albendazole, Prolonged bleeding time, Bleeding time, Ascariasis, Eosinophilia, medicine, Humans, Prospective Studies, Prospective cohort study, Toxocariasis, medicine.diagnostic_test, Platelet Count, business.industry, Infant, General Medicine, medicine.disease, Surgery, Child, Preschool, Female, medicine.symptom, business, medicine.drug
Abstract

Objective To investigate the aetiology of multiple ecchymoses associated with eosinophilia. Setting Professorial Paediatric Unit (PPU) at Lady Ridgeway Hospital (LRH) for children, Colombo. Design Prospective study from July 1998 to April 2000. Materials and methods Patients admitted to the PPU with multiple ecchymoses associated with an absolute eosinophilia (>lxl07l) were investigated further to determine the possible aetiology; bleeding time, clotting time, platelet count, platelet function tests, stools examination and toxocara antibody tests were performed. Patients who were positive for toxocara were treated either with thiabendazole or albendazole. Patients who had geohelminth infestations were treated with mebendazole. Results 14 children (11 boys) were studied. 7 were between 1 and 5 years, and 7 were above 5 years of age. The mean eosinophil count was 4.3x1071. All patients had a prolonged bleeding time, but clotting time and platelet counts (mean value 220x1071) were normal. Platelet function tests were done in 5 patients. Twelve patients were positive for toxocariasis and the other 2 were positive for ascariasis. All children who were positive for toxocariasis had contact with pet cats or dogs. Six patients were treated with thiabendazole and 6 with albendazole. The two patients who had ascariasis were treated with mebendazole. Posttreatment mean eosinophil count was 0.63x1071, and the bleeding time was 4 minutes. Conclusion Toxocariasis could present with ecchymoses due to an acquired bleeding disorder. Awareness of this would help to investigate, diagnose and treat early, and lessen parental anxiety. DOI: http://dx.doi.org/10.4038/cmj.v46i4.6438 Ceylon Medical Journal 2001; 46(4): 130-131

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