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The article reflects on the progress made in the fight against discrimination and stigma in relation to HIV/AIDS over the past decade. It highlights the positive impact of measures such as self-testing, pre-exposure prophylaxis (PrEP), and antiretroviral therapy (ART) in reducing new HIV cases and mortality rates. However, it also acknowledges that discrimination and stigma still persist, particularly affecting transgender individuals who experience higher rates of HIV prevalence and discrimination. The article emphasizes the importance of culturally competent and respectful care for transgender individuals and calls for governments and international agencies to establish policies that address social determinants and intersectional stigma to ensure equity, dignity, and health for all. [Extracted from the article]