1. Exploring the relationship between white matter integrity, cocaine use and GAD polymorphisms using Bayesian Model Averaging.
- Author
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Alballa T, Boone EL, Ma L, Snyder A, and Moeller FG
- Subjects
- Adult, Bayes Theorem, Brain diagnostic imaging, Brain drug effects, Cerebellum diagnostic imaging, Cerebellum drug effects, Cocaine-Related Disorders epidemiology, Cocaine-Related Disorders pathology, Corpus Callosum diagnostic imaging, Corpus Callosum drug effects, Diffusion Tensor Imaging, Female, Genetic Association Studies, Humans, Male, Middle Aged, White Matter drug effects, Young Adult, Cocaine adverse effects, Cocaine-Related Disorders genetics, Genetic Predisposition to Disease, Glutamate Decarboxylase genetics, White Matter diagnostic imaging
- Abstract
Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships between the impaired white matter and glutamic acid decarboxylase (GAD) polymorphisms. This work explored the two-way and three-way interactions between GAD1a (SNP: rs1978340) and GAD1b (SNP: rs769390) polymorphisms and years of cocaine use (YCU). GAD1a was associated with more frontal white matter changes on its own but GAD1b was associated with more midbrain and cerebellar changes as well as a greater increase in white matter changes in the context of chronic cocaine use. The three-way interaction GAD1a|GAD1b|YCU appeared to be roughly an average of the polymorphism two-way interactions GAD1a|YCU and GAD1b|YCU. The three-way interaction demonstrated multiple regions including corpus callosum which featured fewer significant voxel changes, perhaps suggesting a small protective effect of having both polymorphisms on corpus callosum and cerebellar peduncle., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
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