5 results on '"Cell Membrane"'
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2. High-Fat High-Saturated Diet.
- Author
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Capel, Frederic and Capel, Frederic
- Subjects
Biology, life sciences ,Food & society ,Research & information: general ,2DE ,GFAP ,HFD ,JNK ,MALDI TOF/TOF ,SFA ,TLR4 ,Western diet ,adipose tissue ,ageing ,aminopeptidase activity ,arterial stiffness ,brain ,caloric restriction ,cardiac muscle ,cell membrane ,cholesterol ,collagen ,dementia ,dietary fats ,endothelial dysfunction ,fatty acids ,fiber ,free fatty acid ,genomics ,heart ,high fat diet ,high-fat diet ,hyperlipidemia ,inflammation ,insulin receptor ,insulin resistance ,insulin signaling ,intermittent fasting ,inulin ,isocaloric substitution ,lipid ,liver ,macronutrients ,males ,metabolic syndrome ,metabolism ,microRNA ,microbiota ,microvascular ,mitochondria ,monounsaturated fatty acids ,muscle mass ,muscle strength ,nitric oxide ,nonhuman primates ,nutriproteomics ,obesity ,olive oil ,omega 3 fatty acids ,omega-3 PUFA ,omega-6 PUFA ,omega-6/omega-3 ratio ,phospholipids ,physical activity ,polyunsaturated fatty acids ,preadipocyte ,proteomics ,purified high-fat diets ,renin-angiotensin-system ,rodent models of type 2 diabetes ,saturated fatty acids ,sphingolipids ,transcriptome ,type 2 diabetes ,vascular remodeling ,western-style diet - Abstract
Summary: Dietary fat quality is a crucial determinant of several physiological, biochemical and molecular processes in the body, tissues and cells. As a source of energy, Fatty Acids (FA) are mainly stored in fat cells and within lipid droplets (LD) in oxidative and steroidogenic tissues, but significant amounts are also found in cell membranes where their structural role is crucial for membrane protein functions and the control of cellular functions. Differential effects have been identified between different types FA on inflammatory and metabolic diseases during obesity or in response to physical exercise and chronic diseases. The most recent dietary guidelines advise that lipids should represent 35% of the daily energy intake in order to prevent deleterious effects of high glycaemic index carbohydrates and deficiency in essential fatty acids. Hence, the prevalence of obesity could rise dramatically despite a fall in total fat intake. Advice is more focused on the improvement of the quality of fat than on the reduction of total fat intake. Dietary fat sources provide a mixture of saturated FA (SFA), monounsaturated FA (MUFA) and polyunsaturated FA (PUFA). Most institutional dietary guidelines claim that the consumption of SFA should be limited to the expense of MUFA and PUFA as a nutritional strategy for the prevention of chronic diseases. The role of dietary SFA and MUFA in cardiometabolic risk remains controversial in the scientific community. This special issue was proposed to publish articles that bring new elements into the topic by collecting recent advances for students and professionals involved in lipid and health.
3. Mortal coils: the organism.
- Author
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Cotterill, Rodney
- Abstract
The evolution of the horse was certainly a most tortuous process. None of your seven day nonsense! Seven days' labour wouldn't evolve one primitive earthworm. There are interesting parallels between the structuring of multicellular organisms and societies. We see the same elements of aggregation, communication, commitment and differentiation, and although some regret the decline of the protean ideal, specialization was a minor penalty to pay for the development of modern society. After all, more people have flown in aeroplanes than ever held a pilot's licence, and more have enjoyed the benefits of surgery than ever wielded a scalpel. And how many of us would be meat eaters if we had to do our own butchering? There are even similarities in the way societies and multicellular organisms subordinate the individual to the point of dispensability. A nation survives the death of any citizen, however prominent, and a mature organism hardly seems to notice replacement of its individual cells. Moreover, it now appears that the collective structure has a vested interest in the mortality of its members; the multicellular organism follows a policy of programmed death, and a steady turnover increases the chance of a favourable mutation. This too might have its social counterpart; what happens to individual members after they have procreated is of minor importance, and old worn-out citizens are replaced by fresh young individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
4. The essential bag: the cell.
- Author
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Cotterill, Rodney
- Abstract
A million million spermatozoa, All of them alive: Out of their cataclysm but one poor Noah Dare hope to survive. And among that billion minus one Might there have chanced to be Shakespeare, another Newton, a new Donne, But the One was Me. Although biopolymers are more sophisticated than their simpler cousins, such as polythene and rubber, this alone does not give them an obvious reason for existing. Nucleic-acid codes for proteins, some of which contribute to the formation of further nucleic acid, but if these products were free to float away through the surrounding water, no advantage would be gained by the original molecule. The essential extra factor was discovered over 300 years ago. In 1663, using one of the earliest microscopes, Robert Hooke observed that cork has a structure reminiscent of a honeycomb, with pores separated by diaphragms so as to produce a collection of little boxes, which he called cells. Their universality was not appreciated until 1824, when Henri Dutrochet concluded that entire animals and plants are aggregates of cells, arranged according to some definite plan. He also suggested that growth is caused by an increase in either cell size or cell number, or both. The idea of the cell was further elevated in 1838, when Matthias Schleiden proposed that it is the basic structural unit in all organisms. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
5. Strangeness in proportion: liquid crystals.
- Author
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Cotterill, Rodney
- Abstract
There is no excellent beauty that hath not some strangeness in the proportion. Most substances can exist in three different states: solid, liquid and gas. The temperature, pressure and density collectively determine which form is adopted, and changes in the imposed conditions can produce the melting and boiling phase transitions. The solid state is usually crystalline, but some solids have the meta-stable glass structure. Differences between the three fundamental states are often depicted by simple diagrams in which atoms are represented by circles. For a gas, the circles are drawn randomly, with the distance between neighbouring circles somewhat larger than the circle diameter. The condensed states, crystal and liquid, are illustrated by arrangements in which the distances between the centres of neighbouring circles are comparable to the diameters, the difference between these forms lying mainly in the regular arrangement of the former and the relative randomness of the latter. We can go a long way with such models because real atoms are indeed roughly spherical. This is particularly true for noble gases such as argon and neon, because of their closed electron shells, but it is a reasonable approximation for all atoms. The question arises as to what happens if the atoms are replaced by molecules elongated in one direction. The answer is to be found in that peculiar intermediate state of matter: the liquid crystal. A description of arrangements in terms of positions of centres of gravity is inadequate for elongated molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
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