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8. Molecular Typing of the MHC Class I Chain-Related Gene Locus.

Author

Walker, John M., Powis, Stephen H., Collins, R. W. M., Stephens, Henry A. F., and Vaughan, Robert W.

Abstract

The human major histocompatibility complex (MHC) class I chain-related genes A and B (MICA and MICB) are located within the human leukocyte antigen (HLA) class I region of chromosome 6 (1). Their organization, expression, and products differ considerably from classical HLA class I genes (2). MIC proteins are considered to be markers of "stress" in the epithelia (3), and they act as ligands for cells expressing a common activatory natural killer cell receptor (NKG2D) (4). MIC proteins are also highly polymorphic (5), although the functional implications of this polymorphism remain unclear (6). [ABSTRACT FROM AUTHOR]

Published
2003
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