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4. List of contributors

Author

Abaza, Ronney, primary, Abou Zeinab, Mahmoud, additional, Ahmed, Mutahar, additional, Allaf, Mohamad E., additional, Aminsharifi, Alireza, additional, Autorino, Riccardo, additional, Bednarz, Christopher, additional, Bertolo, Riccardo, additional, Billah, Mubashir, additional, Chen, Grace, additional, Cheng, Nathan, additional, Covas Moschovas, Marcio, additional, Crivellaro, Simone, additional, Dasgupta, Prokar, additional, Gabrielson, Andrew T., additional, Garisto, Juan, additional, Huge, Christian, additional, Kaouk, Jihad, additional, Kogan, Paul, additional, Kruse, Michelle, additional, Patel, Vipul, additional, Pierorazio, Phillip M., additional, Ramakrishnan, Venkat M., additional, Reeves, Fairleigh, additional, Sheckley, Fahad, additional, Stifelman, Michael, additional, Wang, Shirley L., additional, and White, Wesley M., additional

Published
2022
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29. CONTRIBUTORS

Author

ABBOU, CLÉMENT-CLAUDE, primary, AHLERING, THOMAS E., additional, ALBANI, JUSTIN M., additional, BADANI, KETAN K., additional, BARRET, ERIC, additional, BARRISFORD, GLEN W., additional, BARTSCH, GEORG, additional, BORIN, JAMES F., additional, CATHELINEAU, XAVIER, additional, CHALLACOMBE, BEN, additional, CHITWOOD, W. RANDOLPH, additional, CLAYMAN, RALPH V., additional, DASGUPTA, PROKAR, additional, PIZZO, J. DEL, additional, FUMO, MICHAEL J., additional, GETTMAN, MATTHEW T., additional, GILL, INDERBIR S., additional, GURU, KHURSHID, additional, HARMON, JUSTIN, additional, HEGARTY, NICHOLAS J., additional, HEMAL, ASHOK K., additional, HERRELL, S. DUKE, additional, HORNINGER, WOLFGANG, additional, HOZNEK, ANDRÁS, additional, KAUFMAN, MELISSA R., additional, KRAMBECK, AMY E., additional, KUMAR, RAJEEV, additional, KYPSON, ALAN P., additional, LEE, DAVID I., additional, LUNACEK, ANDREAS, additional, MENON, MANI, additional, MOTEN, SIMON C., additional, PATEL, VIPUL R., additional, PEABODY, JAMES O., additional, PESCHEL, REINHARD, additional, PETERS, CRAIG A., additional, RAMANATHAN, RAJAN, additional, RAO, SANDHYA R., additional, ROSE, KIRSTEN, additional, ROZET, FRANÇIOS, additional, SALOMON, LAURENT, additional, SARLE, RICHARD C., additional, SCHACHTER, LEE R., additional, SCHWENTNER, CHRISTIAN, additional, SHAH, SAGAR R., additional, SKARECKY, DOUGLAS W., additional, SMITH, JOSEPH A., additional, STRASSER, HANNES, additional, TAKENAKA, ATSUSHI, additional, TEWARI, ASHUTOSH, additional, and VALLANCIEN, GUY, additional

Published
2008
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31. Intravesical Therapy for Refractory Overactive Bladder and Detrusor Overactivity in Adults: Botulinum Toxin-A.

Author

Sahai, Arun, Seth, Jai, Khan, Muhammed Shamim, and Dasgupta, Prokar

Abstract

It has been 11 years since the first publications on the use of intradetrusor botulinum toxin-A (BTX-A) injections to treat neurogenic detrusor overactivity (NDO) in patients with spinal cord injury (SCI) OnabotulinumtoxinA (Botox®; Allergan, Ltd., Irvine, USA) has recently been approved for use in the bladder of neurogenic patients with spinal cord injury or multiple sclerosis in various parts of the world including the USA and UK. In the near future, it is expected that the FDA in the USA and the MHRA in Europe will approve the use of this toxin in idiopathic detrusor overactivity (IDO). Over the last decade, there has been an explosion of publications on the use of this bladder therapy which is primarily used in patients with symptoms of overactive bladder (OAB) and/or detrusor overactivity (DO) who have failed conservative measures and oral medication with antimuscarinics. This is typically due to poor efficacy with antimuscarinics or poor tolerability due to side effects such as dry mouth, dry eyes, blurred vision and constipation. Initially proof of concept/open labelled studies were conducted, whilst later studies focussed on mechanisms of action. From these studies it became apparent that BTX was not simply working by efferent blockade at the neuromuscular junction, as in skeletal muscle, but was likely to have an effect on sensory nerves. Later publications emerged on technique of administration and evidence from level 1 small randomised blinded placebo-controlled trials in both NDO and IDO. Recently drug sponsored phase II and III double-blind randomised placebo-controlled trials have been conducted in both NDO and IDO. These trials are now published with the exception of the phase III data in IDO at the present time. [ABSTRACT FROM AUTHOR]

Published
2014
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