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Drug-induced anaphylaxis prevents the utilization of antibiotic drugs to patients in need of first-line therapy, including those with cystic fibrosis. Avoidance of antibiotic therapy may be limited by the severity of the infection and the microbial sensitivity. Rapid desensitization for antibiotic-induced drug allergies is the induction of temporary clinical unresponsiveness to antibiotics by gradual reintroduction of small doses of antibiotic until the full antibiotic dose is delivered. Clinical unresponsiveness can be maintained until completion of the antibiotic course by regular administration of the antibiotic allowing safe administration of first-line medications to patients who have presented with hypersensitivity reactions to those medications, including anaphylaxis. Principles, indications, targets and management of rapid desensitization procedures, including IgE- and non-IgE-dependent hypersensitivity reactions for the most relevant groups of antibiotics, antifungals and antivirals will be reviewed, and rapid desensitization protocols will be addressed for each group. [ABSTRACT FROM AUTHOR]