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This book is a collection of commentaries by Nebraskans about books that have been memorable for them from childhood through adulthood. The book is a record of life-long learning dedicated to Nebraska's youngest readers in the Year of the Young Reader, 1989--a common ground for intergenerational dialogue made possible by the world of books. The main text of the book lists the contributor's name and occupation along with three book titles; one each for the following categories: childhood, youth, and adulthood. The book also lists the titles and authors which were cited by the contributors and lists the titles most frequently named in the last section. (MG)

Aquaculture animals that escape from farms have the potential to create major environmental problems. These include establishment of potentially destructive feral populations (e.g., Pacific oysters [Crassostrea gigas] in Australia, Atlantic salmon [Salmo salar] in British Columbia) and genetic contamination of wild stocks. The latter includes introgression of foreign genes into natural populations from both hatchery-reared fish and genetically modified fish and invertebrates. Concern about these environmental and genetic effects has already led to restrictions on aquaculture industry development and is likely to grow as demand for genetically improved stocks escalates to fulfill production objectives. To circumvent these problems, we have developed a genetic construct that, when properly integrated into production-line fish or invertebrates, should render individuals functionally sterile outside of hatchery conditions. In the hatchery, however, provision of a simple repressor compound at a particular life-history stage allows the animals to be bred and reared as normal. We are developing this "Sterile Feral" technology for both invertebrate and fish species, and we anticipate practical commercial application within a few years. [ABSTRACT FROM AUTHOR]

The curative potential of allogeneic hematopoietic stem cell transplantation in treating cancer is derived in large part from the donor immune system reacting against host or tumor cell antigens to generate a graft-vs-tumor (GVT) effect. Whereas early animal models suggested this allogeneic immune response, evidence for its role in human transplantation was not realized until the late 1970s and early 1980s, when the association between graft-vs-host disease and tumor response became clear. In this chapter, the animal and human data that established the GVT effect as the major therapeutic component of allogeneic hematopoietic stem cell transplantation are reviewed, and ongoing efforts to understand and build on GVT as a therapeutic modality for other tumor types are described. The current thinking on the biology of the effectors and modulators of GVT are discussed. The progress that has been made in clinical application of immunotherapy in the autologous setting and of solid tumor therapy in the allogeneic setting is reviewed. Finally, the potential for continued advances in the efficacy and safety of immunotherapy for cancer is explored, as reflected in recent and ongoing efforts to apply the growing understanding of alloreactivity toward fulfillment of the potential for targeted antitumor therapies. [ABSTRACT FROM AUTHOR]