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A definition of the term "serum sickness" is presented. It refers to a condition caused by in vitro injection of foreign proteins or antigen which then lead to formation of immune complexes called antibody-antigen complexes. The condition was described in 1905. The manifestations of immunological hyperreaction are rashes, fever and nephritis.

An encyclopedia entry for "serum sickness," which refers to an inflammatory condition caused by the deposition of immune complexes in blood vessel walls and tissues, is presented.