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This innovative guide is now in a revised and expanded second edition with an even stronger applied focus. It helps educators harness the potential of single-case design (SCD) as a critical element of data-based decision making in a multi-tiered system of support (MTSS). The authors present simple and complex SCDs and demonstrate their use to defensibly document the effects of academic or behavioral interventions. In a large-size format with lay-flat binding for easy photocopying, the book includes reproducible graphs and other tools; appendices provide guides to analyzing and presenting data in Microsoft Excel. Purchasers get access to a Web page where they can download and print the reproducible materials. New to this edition: (1) Updated to align perfectly with MTSS and current evidence-based practices; (2) Chapter on using SCD in educational research; (3) Greater emphasis on day-to-day educational practice throughout; and (4) Significantly revised discussions of brief experimental analysis, complex SCDs, and advanced empirical analyses.