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In this basic study the interaction of a lateral jet with supersonic external flow was examined. The study consists of wind tunnel experiments at Mach 5 in the Ludwieg Tube Facility of the German Aerospace Center (DLR) as well as of numerical simulations with the DLR-TAU-code. The efficiency of two flow control devices (upstream mounted needle and weak jet) for stabilization and control of flow separation by means of bow shock attenuation was investigated. The results show that the investigated flow control devices are able to influence the shape and size of the main separation zone but are not capable to suppress it completely. A comparison of wall pressures and limiting streamline patterns showed reasonable agreement between numerical simulations and experimental data. [ABSTRACT FROM AUTHOR]

Apoptotic cell death mediated through activation of death receptors is essential in the regulation of tissue homeostasis in development and differentiation. The expression of the members of the death receptor family is tightly regulated and varies among tissues. Dysregulation of death receptor expression is implicated in the pathogenesis of various diseases, including cancer, autoimmune disorders, neurodegenerative diseases, and infections. In this chapter we will focus on the stimuli and mechanisms that regulate the expression of death receptors. [ABSTRACT FROM AUTHOR]