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The discovery of the human genome and subsequent expansion of proteomics research combined with emerging technologies such as sophisticated computational biology are producing unprecedented changes in our understanding of the role of tumor suppressors in cell signaling. p53, a key tumor suppressor gene, is mutated in the majority of human cancers. Successful outcome of chemotherapy and radiotherapy, in many cases, depends on functional p53. Therefore, elucidation of the function, regulation, and molecular interactions of p53 with its targets is of great importance for developing successful cancer therapy. Because p53 is a transcription factor with an expanded repertoire of genes that are known to be directly or indirectly under its control, global analysis of gene expression profiles represents the best approach for studying the p53 response to chemotherapeutic agents. Our laboratory and others have used gene expression profiling with microarrays to isolate p53 target genes in an attempt to understand the molecular signaling of p53 and to determine the molecular consequences that follow from treatment of cancer cells with chemotherapeutic agents. Although these attempts have been successful in isolating novel genes, gene expression profiling alone at the transcription level is not sufficient. Most of pharmacological targets are proteins or DNA, not RNA. Therefore, we need an approach that focuses on the molecular profiling of cancer cells at the DNA, RNA, and proteins. In this chapter, key findings on the current genomics and proteomics approaches for isolating p53 targets and their functional analysis are reviewed, and perspective is provided on the potential of integrating both approaches in the molecular pharmacology of p53 signaling. [ABSTRACT FROM AUTHOR]

Ad hoc network is the network which can be considered without a pre-constructed infrastructure, and a mobile node can join the network freely. However, the participation of the mobile nodes to the ad hoc network brings up much burden of re-computation for new routes, because it leads to losing the connection frequently. Therefore, it needs authentication against the mobile nodes. To make that possible, we have two methods: single Certificate Authority(CA) and distributed CA. In the case of single CA method, the wireless network can be collapsed owing to expose the CA, but still the distributed CA method is a little safer than previous one because it needs attacks toward a lot of CAs to collapse the network. We can consider secret sharing scheme as the method that constructs the distributed CA system, but it is weak when the network size is too large. In this paper, we suggest hierarchical structure for the authentication method, and show the results of simulation. Keywords: Ad Hoc Network Security, Authentication, Certificate Issuing. [ABSTRACT FROM AUTHOR]

Though authentication using biometric techniques has conveniences for people, security problems like the leakage of personal bio-information would be serious. Even if cancelable biometric is a good solution for the problems, only a few biometric authentication scheme with cancelable feature has been published. In this paper, we suggest a face authentication scheme with two security factors: password and face image. Using matching algorithm in the permuted domain, our scheme is designed to be cancelable in the sense that templates that is composed of permutation and weight vector can be changed freely. [ABSTRACT FROM AUTHOR]

Home Server plays an important role to manage all home network devices and multimedia content services in the digital home. Multimedia collaboration over home networking devices is inhibited by several factors. The decision based on a single input agent to serve all the needs of the home users is to be enhanced to facilitate multi-modal inputs with multiple integrated User Agents working together to facilitate the new generation of dynamic home networking devices. Display has to be adaptive and context sensitive to adapt to the dynamic needs of the user. In this paper, we present a hybrid architectural framework as our recent efforts for extending the functionalities of Home Server in order to support multi-modal context-sensitive multimedia collaboration services. [ABSTRACT FROM AUTHOR]