Schmidt, Axel, Kaufmann, Stefan H. E., Wolff, Manfred H., Mercer, Andrew A., Weber, Olaf, Becker, Marie N., and Moyer, Richard W.
The subfamily Entomopoxvirinae is a related but distinct member of the family Poxviridae. These viruses share many biological features of the poxviruses of chordates, but instead infect the larvae of a number of insect families. The three genera that comprise the entomopoxviruses are the genus Alphaentomopoxvirus, infecting beetles; genus Betaentomopoxvirus, infecting butterflies, moths, grasshoppers, and locusts, and the genus Gammaentomopoxvirus infecting flies and mosquitoes. The entomopoxviruses, like their vertebrate counterparts, have a double-stranded linear DNA genome that is transcribed in a temporal fashion. Entomopoxviruses are occluded in a paracrystalline protein matrix, forming spheroids that protect the virus from environmental conditions. A number of genes are conserved between the entomopoxviruses and chordopoxviruses defining a minimal complement of poxvirus genes. The entomopoxviruses have some unique molecular features. This review covers pathogenesis, transcription, and molecular analysis of the entomopoxviruses. [ABSTRACT FROM AUTHOR]