Search

Your search keyword '"Narfström, Kristina"' showing total 11 results
Start Over Author "Narfström, Kristina" Publication Type Books
11 results on '"Narfström, Kristina"'

2. Visual impairment

Author

Bjerkås, Ellen, primary, Ekesten, Björn, additional, Narfström, Kristina, additional, and Grahn, Bruce, additional

Published
2009
Full Text
View/download PDF

5. Hereditary Retinal Dystrophy of Swedish Briard Dogs

Author

Veske, Andres, primary, Nilsson, Sven Erik G., additional, Finckh, Ulrich, additional, Narfström, Kristina, additional, Petersen-Jones, Simon, additional, Gould, David, additional, Sargan, David, additional, and Gal, Andreas, additional

Published
1997
Full Text
View/download PDF

9. Effective Treatment for the Canine RPE65 Null Mutation, a Hereditary Retinal Dystrophy Comparable to Human Leber's Congenital Amaurosis.

Author

Tombran-Tink, Joyce, Barnstable, Colin J., Narfström, Kristina, Tullis, Gregory E., and Seeliger, Mathias

Abstract

Mutations in the human retinal pigment epithelial (RPE)65 gene underlie some forms of early childhood blindness, including a form of Leber's congenital amaurosis (LCA), early-onset severe retinal dystrophy, and juvenile retinitis pigmentosa (RP) (1-4). LCA is an autosomal recessively inherited disease (5), although a few families with autosomal dominant inheritance have also been reported (6). In general, LCA is diagnosed when there is marked visual impairment from birth, whereas the disease is considered juvenile RP if vision is lost during the first 2 yr of life. Mutations in several genes other than RPE65 have also been identified in other ocular phenotypes designated as LCA (7). [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

10. Assessing the Efficacy of Gene Therapy in Rpe65-/- Mice Using Photoentrainment of Circadian Phythm.

Author

Back, Nathan, Cohen, Irun R., Kritchevsky, David, Lajtha, Abel, Paoletti, Rodolfo, Hollyfield, Joe G., Anderson, Robert E., LaVail, Matthew M., Stoddart, Chris W., Yu, Meaghan J. T., Martin-Iverson, Matthew T., Daniels, Dru M., Lai, C.-May, Barnett, Nigel L., Redmond, T. Michael, Narfström, Kristina, and Rakoczy, P. Elizabeth

Abstract

Gene therapy (GT) can be described as the in vivo transfer of DNA for therapeutic purposes. In the case of congenital retinal dystrophies (RD), GT can only be considered a successful treatment option if the gene transfer results in the restoration of vision at some level. Thus, a critical component of developing GT treatments for RDs is assessing the amount of functioning vision that is produced. In mouse models of RD, visual function after gene therapy is tested using techniques such as electroretinograms (ERGs) and retinoid analysis.1-3 A potentially useful addition to these tests would be a murine behavior-based technique,4 like those used with the RPE65 dog model, to demonstrate effective GT-induced visual recovery. [ABSTRACT FROM AUTHOR]

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results