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8. Biological Characteristics of Histamine Receptors in Airways Disease Management.

Author

Shukla, Rajni Kant, Jain, Priyanka, and Bhattacharya, Sandeep

Abstract

Histamine, a biogenic amine is an important mediator isolated from ergot extracts and released from activated mast cells provoked by allergen and has a substantial role in the pathophysiology of asthma. It not only mediates multiple biological actions but also play an important role in vascular dilatation and smooth muscles contraction during anaphylaxis. Cell growth and differentiation, a significant event in the biological system have been regulated by its receptors both in normal and transformed tissues. The discovery of noble histamine H4-receptors prompted us to reinvestigate the role of histamine in pulmonary allergic responses. In asthma and other types of allergic inflammation, mast cells and basophils are the postulated major sources of histamine. In this chapter, we would highlight the potential histamine role in airways diseases and try to update the current aspects of histamine in asthma and fill the gap in existing literature. [ABSTRACT FROM AUTHOR]

Published
2011
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