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Your search keyword '"Retinal ischemia"' showing total 2 results
Start Over Descriptor "Retinal ischemia" Publication Type Books
2 results on '"Retinal ischemia"'

1. Novel Molecules in Diabetes Melitus, Dyslipidemia and Cardiovascular Disease.

Author

Vesa, Cosmin Mihai, Bungau, Simona Gabriela, and Vesa, Cosmin Mihai

Subjects
Biology, life sciences, Research & information: general, ADMET, GIP, GLP-1, HUVEC, LY3298176, PFK15 synthesis, SUMMIT, SURMOUNT, SURPASS, SYNERGY, Tirzepatide, abietane diterpenoids, adolescents, angiogenesis, cardiovascular medicine, children, common carotid artery occlusion, diabetes, diabetes mellitus, dyslipidemia, ejection fraction, empagliflozin, endothelial nitric oxide synthase, glucagon, heart failure, hsa-miR-193b-3p, hypertension, incretins, inflammation, leptin, levopimaric acid, lipid metabolism, liver, meta-analysis, metabolic syndrome, molecular docking, morbidity, mortality, n/a, neuroprotection, nicotinamide mononucleotide, obesity, oxidative stress, peroxisome proliferator activated receptor gamma coactivator 1 alpha, quinopimaric acid, retinal ischemia, retinal ischemia/reperfusion, sacubitril/valsartan, sphingolipids, sphingomyelinase, statin, sunitinib L-malate, synergy, thromboxane prostanoid receptor, type 2 diabetes, type 2 diabetes mellitus, vasorelaxation, α-glucosidase
Abstract

Summary: The purpose of this reprint based on the Special issue "Molecules in Diabetes Melitus, Dyslipidemia and Cardiovascular Disease", IJMS journal, MDPI, is to present the impact in clinical practice as well as in medical research of novel molecules that have been introduced in the treatment of diabetes mellitus, dyslipidemia, and cardiovascular disease.

2. Autophagy Induction Does Not Protect Retina Against Apoptosis in Ischemia/Reperfusion Model.

Author

Produit-Zengaffinen, Nathalie, Pournaras, Constantin J., and Schorderet, Daniel F.

Abstract

The role played by autophagy after ischemia/reperfusion (I/R) in the retina remains unknown. Our study investigated whether ischemic injury in the retina, which causes an energy crisis, would induce autophagy. Retinal ischemia was induced by elevation of the intraocular pressure and modulation of autophagic markers was analyzed at the protein levels in an early and late phase of recovery. Following retinal ischemia an increase in LC3BII was first observed in the early phase of recovery but did not stay until the late phase of recovery. Post-ischemic induction of autophagy by intravitreal rapamycin administration did not provide protection against the lesion induced by the ischemic stress. On the contrary, an increase in the number of apoptotic cells was observed following I/R in the rapamycin treated retinas. [ABSTRACT FROM AUTHOR]

Published
2014
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