Search

Fracture healing is a complicated process involving many growth factors, cells, and physical forces. In cases, where natural healing is not able, efforts have to be undertaken to improve healing. For this purpose, tissue engineering may be an option. In order to stimulate cells to form a bone tissue several factors are needed: cells, scaffold, and growth factors. Stem cells derived from bone marrow or adipose tissues are the most useful in this regard. The differentiation of the cells can be accelerated using mechanical stimulation. The first part of this chapter describes the influence of longitudinal strain application. The second part uses a sophisticated approach with stem cells on a newly developed biomaterial (Sponceram) in a rotating bed bioreactor with the administration of bone morphogenetic protein-2. It is shown that such an approach is able to produce bone tissue constructs. This may lead to production of larger constructs that can be used in clinical applications. [ABSTRACT FROM AUTHOR]

We present near-infrared speckle interferometry of the OH/IR star OH 26.5+0.6 in the K' band obtained with the 6m telescope of the Special Astrophysical Observatory (SAO) in Oct. 2003. At a wavelength of λ = 2.13 μm the diffraction-limited resolution of 74 mas was attained. The reconstructed visibility reveals a spherically symmetric, circumstellar dust shell (CDS) surrounding the central star. In accordance with the deep silicate absorption feature in the spectral energy distribution (SED), the drop of the visibility function to a value of 0.36 at the cutoff frequency indicates a rather large optical depth of the CDS. To determine the structure and the properties of the CDS of OH 26.5+0.6, radiative transfer calculations using the code DUSTY[3] were performed to simultaneously model its visibility and the SED. Since OH 26.5+0.6 is highly variable, the observational data taken into consideration for the modeling correspond to different phases of the object's variability cycle. As in the case of another OH/IR star, OH 104.9+2.4 (see [5] and Riechers et al., this volume), we used these observational constraints at different epochs to derive several physical parameters of the central star and the CDS of OH 26.5+0.6 as a function of phase [ABSTRACT FROM AUTHOR]

We present near-infrared speckle interferometry of the OH/IR star OH 104.9+2.4 in the K' band obtained with the 6m telescope of the Special Astrophysical Observatory (SAO) in Sep. 2002 and Oct. 2003. At a wavelength of λ = 2.13 μ m the diffraction-limited resolution of 74 mas was attained. The reconstructed visibility reveals a spherically symmetric, circumstellar dust shell (CDS) surrounding the central star. The visibility function shows that the stellar contribution to the total flux at λ = 2.13 μ m is less than 30% at all phases, indicating a rather large optical depth of the CDS. The azimuthally averaged 1-dimensional Gaussian visibility fit yields a diameter of 47 ± 3 mas (FHWM), which corresponds to 112 ± 13 AU for an adopted distance of D = 2.38 ± 0.24 kpc.To determine the structure and the roperties of the CDS of OH 104.9+2.4, radiative transfer calculations using the code DUSTY cite{rie:ie95} were performed to simultaneously model its visibility and the spectral energy distribution (SED). Since OH 104.9+2.4 is highly variable, the observational data taken into consideration for the modeling correspond to different phases of the object's variability cycle. This offers the possibility to derive several physical parameters of the central star and its CDS as a function of phase [ABSTRACT FROM AUTHOR]