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10. I>In Vivo Perturbation of Lysosomal Function Promotes Neurodegeneration in the PS1M146V/APPK670N,M671L Mouse Model of Alzheimer's Disease Pathology.

Author

Nixon, Ralph A., Mathews, Paul M., Cataldo, Anne M., Mohan, Panaiyur S., Schmidt, Stephen D., Duff, Karen, Berg, Martin, Marks, Neville, Peterhoff, Corinne, and Sershen, Henry

Subjects
ALZHEIMER'S disease, PATHOLOGY, LYSOSOMES, ORGANELLES, CENTRAL nervous system diseases, PROTEINS, NEURODEGENERATION
Abstract

In Alzheimer's disease, marked activation of the neuronal lysosomal system develops at a very early stage of the disease and intensifies as neurons become evidently compromised. This response, which occurs in virtually all neurons within cell populations susceptible to Alzheimer's disease, is characterized by lysosome proliferation, elevated gene expression and synthesis of lysosmal acid hydrolases, and increased lysosomal protease levels and activities. [ABSTRACT FROM PUBLISHER]

Published
2001

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