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During angiogenesis new blood vessels are formed from pre-existing blood vessels. Tumor angiogenesis enables a small colony of malignantly transformed cells to grow and develop into an invasive cancer. This process is believed to be regulated by a change in the balance between endogenous pro-angiogenic and anti-angiogenic factors, and thus tumor growth requires a shift towards pro-angiogenesis. There are now extensive genetic data available from animal models that illustrate that the ceiling growth rate of a cancer is strongly influenced by the angiogenic potential of the host. This concept will be discussed in this chapter. We will also introduce the reader to the known matrix-derived and other endogenous inhibitors on angiogenesis, and their mechanism of action. [ABSTRACT FROM AUTHOR]