1. The Conformational Universe of Proteins and Peptides: Tales of Order and Disorder.
- Author
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Leone, Marilisa and Leone, Marilisa
- Subjects
Research & information: general ,ABC transporter ,ACE2 ,ATP analogues ,ATP hydrolysis ,DnaB helicase ,ELDOR-detected NMR ,Friedman's test ,High Hydrostatic Pressure ,IDP 1 ,ITEM-TWO ,MDM2 7 ,MELD×MD 4 ,NAD(P)H-dependent oxidoreductase ,NMR ,SARS-CoV-2 ,TRIOBP ,actin ,advanced sampling 5 ,antifungal activity ,apparent gas phase activation energies ,apparent gas phase dissociation constants ,backbone atom coordinate variances and uncertainties ,binding 2 ,bioinformatics ,biopesticides ,cancer ,charged amino acids ,cofactor binding and release ,cytoskeleton ,deafness ,denatured state ensemble ,disordered structure ,gas phase immune complex dissociation ,hearing loss ,immunoglobulin domain ,insecticidal activity ,interdomain cleft dynamics ,intrinsically disordered proteins ,ion-pairing interaction ,mass spectrometric epitope mapping ,mechanism of action ,mental illness ,molecular dynamics 3 ,molecular dynamics simulations ,n/a ,nanobody ,native mass spectrometry ,p53 6 ,peptide ,peptides ,protein aggregation ,protein coil library ,protein folding ,protein structure ,schizophrenia ,side-chain length ,solid-state NMR ,superimposition ,transgenic crops ,transmission ,viral spike receptor-binding domain ,zinc-containing alcohol dehydrogenase ,β-hairpin - Abstract
Summary: Proteins represent one of the most abundant classes of biological macromolecules and play crucial roles in a vast array of physiological and pathological processes. The knowledge of the 3D structure of a protein, as well as the possible conformational transitions occurring upon interaction with diverse ligands, are essential to fully comprehend its biological function.In addition to globular, well-folded proteins, over the past few years, intrinsically disordered proteins (IDPs) have received a lot of attention. IDPs are usually aggregation-prone and may form toxic amyloid fibers and oligomers associated with several human pathologies. Peptides are smaller in size than proteins but similarly represent key elements of cells. A few peptides are able to work as tumor markers and find applications in the diagnostic and therapeutic fields. The conformational analysis of bioactive peptides is important to design novel potential drugs acting as selective modulators of specific receptors or enzymes. Nevertheless, synthetic peptides reproducing different protein fragments have frequently been implemented as model systems in folding studies relying on structural investigations in water and/or other environments.This book contains contributions (seven original research articles and five reviews published in the journal Molecules) on the above-described topics and, in detail, it includes structural studies on globular folded proteins, IDPs and bioactive peptides. These works were conducted usingdifferent experimental methods.