Search

Your search keyword '"Antigen"' showing total 3 results
Start Over Descriptor "Antigen" Publication Type Conference Materials
3 results on '"Antigen"'

1. Artificial Immune Systems and Missing Features Classification Approach.

Author

GALLOVÁ, Štefánia

Subjects
IMMUNE system, ARTIFICIAL intelligence, MACHINE learning, COMPUTATIONAL intelligence, MISSING data (Statistics), DATA analysis
Abstract

Artificial Immune Systems are one part of the computational intelligence area. They are inspired by the biological immune systems. Learning, inference and prediction in the presence of missing data are important problems in machine learning and data analysis. This paper provides a contribution to some classification problem solving with missing attributes values presence within artificial immune system environment. [ABSTRACT FROM AUTHOR]

Published
2012

2. Binding in Human Antibody-DNA Interface: A Computer-Simulation Study.

Author

Su, Zhi-Yuan and Wang, Yeng-Tseng

Abstract

The stretching, that is, the distance between the centre of mass of the ssDNA and the antibody, has been studied using the potential of mean force calculations based on molecular dynamics and the explicit water model. Our simulations indicate that the 6 residues Gln43, Gly44, Arg98, Tyr100, Val136 and Thr137, pair interactions of antibody-ssDNA, and the 5 interprotein molecular hydrogen bonds might play important roles in the antibody-ssDNA interaction, and this finding may be useful for protein engineering of this antibody-ssDNA structure. In addition, the 6 residues Gln43, Gly44, Arg98, Tyr100, Val136 and Thr137 might be more important in the development of bioactive antibody analogues. [ABSTRACT FROM PUBLISHER]

Published
2012
Full Text
View/download PDF

3. Virus-Like Particles as vaccine antigens and adjuvants: application to chronic disease, cancer immunotherapy and infectious disease preventive strategies.

Author

Guillén, G., Aguilar, J.C., Dueñas, S., Hermida, L., Guzmán, M.G., Penton, E., Iglesias, E., Junco, J., Torrens, I., Lobaina, Y., Muzio, V., and Herrera, L.

Subjects
VACCINE research, PREVENTION of chronic diseases, CANCER immunotherapy, PREVENTION of communicable diseases, IMMUNOLOGICAL adjuvants, IMMUNE response, CELLULAR immunity, ANTIGENS
Abstract

Abstract: Existing vaccines are mainly limited to the microorganisms we are able to culture and produce and/or to those whose killing is mediated by humoral responses. It has been more difficult to develop vaccines capable to induce functional cellular responses needed to prevent or cure chronic diseases. Several results suggest that specific enhancement of T-cell responses is nevertheless possible in persistently infected patients to treat chronic diseases including cancer. This work presents preclinical and clinical results obtained using virus like particles (VLPs) as a vaccine platform. VLPs based on envelope, membrane or nucleocapsid microbial proteins are able to stimulate mucosal as well as systemic immunity and induce a strong immune response after nasal or systemic administration in mice, non human primates and humans. In addition, the immune response obtained is biased in a Th1 direction. VLPs were able to potentiate humoral and cellular immune responses against several viral and cancer antigens as measured by LPA and IFN-γ ELISPOT assays. Studies in animals and humans with nasal and systemic formulations show that it is possible to induce functional immune responses against HBV, HCV, dengue as well as against prostate and cervical cancers. [Copyright &y& Elsevier]

Published
2010

Catalog

Books, media, physical & digital resources
See catalog results