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Aim: We aimed to clarify the relationship between home environment and burnout in female nurses with preschool-age children who use day nursery in Japan. Methods: The subjects included 832 female nurses with preschool-age children who use day nursery agreed to cooperate with our study in Japan. In order to provide information, the nurses completed a survey evaluating home environment and burnout. Home environment was composed of four categories: human stimulation, social stimulation, avoidance of restriction and social support. Burnout was operationally defined as a total MBI score in the highest tertile. Results: We obtained valid responses from 528 nurses who had consented to join the study. Chi-square analysis indicated the significant differences in relationship between all categories of home environment and burnout. Conclusions: Female nurses with preschool-age children who use day nursery in Japan tend to have risk in home environment if they burned out. [ABSTRACT FROM AUTHOR]