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The syndrome of polycyctic ovary (PCOS), is a significant disorder of gynocology affects frome three to ten percent of female in the age of reproduction. PCOS is associated with ovulation problems and menstrual irregularities, as well as abdominal obesity. Kisspeptins are peptides that control the hypothalamic-pituitary-gonadal (HPG) axis and are generated by the KISS1 gene. Discuss the association between the action of this peptide on Polycystic ovarian syndrome charecterstics and defferent weight individual. The research involved one handerend and five individuals, with seventy female with PCOS being divided into 17 obese, 18 overweight, and 34 normal weight groups based on their BMI. The remaining 36 women are from the control group, who appear to be in good health. Individual that have poly cystic overy syndrome which chosen from different part such as Karbala Department of infertility Teaching Hospital and individuals that attended to private clinics. The hormonal profile and serum humane Kisspeptin1 were measured using the ELISA method. In comparison to the control group, Kisspeptin1 revealed a highly different results in patient with syndrom for obese (397.4 ± 138.3), overweight (420.2 ± 150.7), and normal weight patients (371.9 ± 87.3). Luteinizing hormone level in PCOS women were substantially greater (P.value = 0.05) than in the control group. Kisspeptin1 levels do not differ significantly (p.value > 0.05) across the three age groups. The results showed that when compared to the control group, highly difference result in Kisspeptin1 concentration patients with syndroms who were obese, overweight, or normal weight. Our findings imply that PCOS groups had greater serum kisspeptin1 concentrations than control groups, as well as significant variations in levels among study groups with varied BMIs. Kisspeptin's significance in PCOS will need to be investigated further in both experimental and clinical investigations. [ABSTRACT FROM AUTHOR]