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A wide range of targets with laser energies spanning two orders of magnitude have been shot at the National Ignition Facility (NIF). The National Ignition Campaign (NIC) targets are cryogenic with Si supports and cooling rings attached to an Al Thermo-Mechanical Package (TMP) with a thin (30 micron) Au hohlraum inside. Particular attention is placed on the low-energy shots where the TMP is not completely vaporized. In addition to NIC targets, a range of other targets has also been fielded on NIF. For all targets, simulations play a critical role in determining if the risks associated with debris and shrapnel are acceptable. In a number of cases, experiments were redesigned, based on simulations, to reduce risks or to obtain data. The majority of these simulations were done using the ALE-AMR code, which provides efficient late-time (100 - 1000X the pulse duration) 3D calculations of complex NIF targets. [ABSTRACT FROM AUTHOR]