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The work shows an original psychophysiological approach in establishing a psychological profile by using an inferential fractal method of access to the neocortex by stimulating the phasic stage of epidermis. The mathematical model used in analysing the functions of psychophysiological inference may show the specifics of some behavioural styles associated with psychological typologies. [ABSTRACT FROM AUTHOR]

In this work, we investigated the effect of low intensity pulsed focused ultrasound in the brain of two awake Maccaca Mulatta monkeys using the antisaccade (AS) paradigm. The objective of the study was to determine if transcranial ultrasound has an effect on behavioural tasks in awake animal involving a specific brain structure. Two Maccaca Mulatta monkeys (Y and L) were trained to perform antisaccade (AS) movements where they initially have to fix a central stimulus on a screen and then refrain from looking at an appearing peripheral target but instead initiate as soon as possible a saccade towards the opposite direction. In order to investigate the effect of low intensity focused ultrasound, a continuous 100 ms sonication pulse (derated pressure estimated at 0.35 ± 0.05 MPa) was focused at the frontal eye field using a 320 kHz transducer (H115, Sonic Concept, Bothell, WA, USA). Ipsilateral mean AS latencies with ultrasound stimulation were significantly (t-test;monkey Y: p=.0345, monkey L: p= .0311) increased compared to the non-stimulation condition (monkey Y: +14ms; monkey L: +15 ms). The study demonstrates the feasibility of using focused ultrasound to causally modulate behaviour in awake non-human primate brain. [ABSTRACT FROM PUBLISHER]

Electrical Neurostimulation has been effective for treating and reducing symptoms of neurological diseases, for alleviating some types of chronic pain and for restoring sensory or neuromuscular deficits. Because of the energy and size limitation on fully implantable devices, it is important to keep devices small and at low power. It was already demonstrated that non-rectangular waveforms provide a more energy-efficient neural stimulation. In this article is shown how a hybrid architecture of current steering DAC is suitable to this application, because of its specifications: the ability to convert several waveforms directly from digital to analog current signals, low power consumption, small chip area requirement, the capability of sharing common stages and also for its simplicity. An ASIC has been developed composed of four stimulator channels, capable of driving several current waveforms. The design is implemented in 130 nm CMOS technology. [ABSTRACT FROM PUBLISHER]