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The new magnetic reactor based solid phase synthesis strategy allows magnetic immobilization of nanoparticles in order to perform the derivatization step(s) with relevant biomolecules on the immobilized magnetic nanoparticles. Monoclonal Mouse anti-Human CD11b shows affinity toward monocyte/macrophage integrin MAC-1 (CD11b/CD18) which is involved in leukocyte adhesion and functions as a cell receptor and was coupled on superparamagnetic iron oxide nanoparticles (SPIONs) in this reactor. The resulting anti-CD11b derivatized SPIONs were analyzed and compared to conventionally derivatized SPIONs. The reactor-derivatized anti-CD11b-SPIONs show enhanced colloidal stability during and after the surface derivatization steps. The yield and quality of the resulting particles can also be significantly improved in terms of reaction time and yield, particle size distribution, and scalability by using this magnetic reactor. These highly specific particles were successfully used in imaging studies of monocytes. [ABSTRACT FROM AUTHOR]