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The aim of this systematic literature review (SLR) is to explore how Fourth Industrial Revolution (4IR) digital technologies are transforming the healthcare sector. Peer-reviewed, full-text research papers published between January 2016 and April 2021, which focused on data-driven healthcare, health data management systems, and the disruptive role of digital technologies in healthcare were retrieved from three electronic databases, namely PubMed Central, Institute of Electrical and Electronics Engineers (IEEE) and MEDLINE. Articles included in the SLR were identified and selected using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline. Three main themes were identified from 84 research papers included in the SLR, namely, (i) digital technologies driving the transformation of healthcare, (ii) the impact of digital transformation on healthcare, and (iii) areas of transformation in healthcare. The results showed that technological innovations can mitigate the impact of unequal distribution of healthcare services, reduce healthcare costs, improve the quality of care, and the quality of life for patients and healthcare professionals. [ABSTRACT FROM AUTHOR]

Personalised medicine (PM) represents an excellent case to study a current business model innovation (BMI). In the life sciences industry the strategic reorientation from a one-fits-all approach to more tailored therapies for stratified subgroups of patients have a tremendous impact not only on the pharmaceutical companies themselves, but also on the various players of the surrounding innovation system. On the basis of an intensive desk and field research we identified the key players as well as their role in and their influences on the PM innovation system. The results indicate that the mutual interactions between the various actors of an innovation system shape and constitute the framework for companies to develop new business models (BM) and that the concept of the dominant logic is not limited to a business or an industry. In the case of PM the dominant logic affects an entire innovation system. [ABSTRACT FROM AUTHOR]