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The highly efficient ultra-low-power management unit is essential in powering low-power wearable electronics. Such devices are powered by a single input source, either by a battery or with the help of a renewable energy source. Thus, there is a demand for an energy conversion unit, in this case, a DC-DC converter, which can perform either step-up or step-down conversions to provide the required voltage at the load. Energy scavenging with a boost converter is an intriguing choice since it removes the necessity of bulky batteries and considerably extends the battery life. Wearable devices are typically powered by a monolithic battery. The commonly available battery such as Alkaline or Lithium-ion, degrade over time due to their life spans as it is limited by the number of charge cycles- which depend highly on the environmental and loading condition. Thus, once it reaches the maximum number of life cycles, the battery needs to be replaced. The operation of the wearable devices is limited by usable duration, which depends on the energy density of the battery. Once the stored energy is depleted, the operation of wearable devices is also affected, and hence it needs to be recharged. The energy harvesters- which gather the available energy from the surroundings, however, have no limitation on operating life. The application can become battery-less given that harvestable energy is sufficiently powering the low-power devices. Although the energy harvester may not completely replace the battery source, it ensures the maximum duration of use and assists to become autonomous and self-sustain devices. The photovoltaic (PV) cell is a promising candidate as a hypothetical input supply source among the energy harvesters due to its smaller area and high power density over other harvesters. Solar energy use PV harvester can convert ambient light energy into electrical energy and keep it in the storage device. The harvested output of PV cannot directly connect to wearable loads for two main reasons. Depending on the incoming light, the harvested current result in varying open-circuit voltage. It requires the power management circuit to deal with unregulated input variation. Second, depending on the PV cell's material type and an effective area, the I-V characteristic's performance varies, resulting in a variation of the output power. There are several works of maximum power point tracking (MPPT) methods that allow the solar energy harvester to achieve optimal harvested power. Therefore, the harvested power depends on the size and usually small area cell is sufficient for micro-watt loads low-powered applications. The available harvested voltage, however, is generally very low-voltage range between 0.4-0.6 V. The voltage ratings of electronics in standard wearable applications operate in 1.8-3 V voltages as described in introduction's application example section. It is higher than the supply source can offer. The overcome the mismatch voltage between source and supply circuit, a DC-DC boost converter is necessary. The switch-mode converters are favoured over the linear converters due to their highly efficient and small area overhead. The inductive converter in the switch-mode converter is common due to its high-efficiency performance. However, the integration of the inductor in the miniaturised integrated on-chip design tends to be bulky. Therefore, the switched-capacitor approach DC-DC converters will be explored in this research. In the switched-capacitor converter universe, there is plenty of work for single-output designs for various topologies. Most converters are reconfigurable to the different DC voltage levels apart from Dickson and cross-coupled charge pump topologies due to their boosting power stage architecture through a number of stages. However, existing multi-output converters are limited to the fixed gain ratio. This work explores the reconfigurable dual-output converter with adjustable gain to compromise the research gap. The thesis's primary focus is to present the inductor-less, switched-capacitor-based DC-DC converter power management system (PMS) supplied by a varying input of PV energy harvester input source. The PMS should deliver highly efficient regulated voltage conversion ratio (VCR) outputs to low-power wearable electronic devices that constitute multi-function building blocks.

A retinol-binding protein (RBP) synthesized and secreted by bovine and ovine allantois in vitro was purified from culture medium. The protein consisted of three isoelectric variants (pI 5.3-6.1) of identical molecular weight of about 23,000 as determined by two-dimensional polyacrylamide gel electrophoresis. Thirty-one of the first 34 N-terminal amino acids of the purified protein from both sources were sequenced and shown to have complete homology with bovine plasma RBP. The UV absorption spectrum and fluorescence excitation and emission spectra of the purified bovine and ovine placental RBP indicated the presence of bound retinol. Rabbit antiserum was raised against purified bovine placental RBP. Metabolic labelling, immunoprecipitation studies demonstrated that the protein was synthesized by bovine and ovine extraembryonic membranes (allantois, chorion and amnion). The protein was also detected in allantoic and amniotic fluids by immunoblotting. With immunocytochemical procedures, the placental RBP was immunolocalized in trophectodermal cells of the chorion, endodermal cells lining the allantois and ectodermal cells lining the amnion. Results from this study suggest that bovine and ovine placental membrane epithelia synthesize and secrete REP. Transport, storage, and metabolism of retinol mediated by placental REP may be essential for normal embryonic development during pregnancy.