Purpose: The purpose of this study was to examine the effect professional foundational physical therapist education program coursework variables have in predicting National Physical Therapy Examination (NPTE) scores. This study examined variables including Anatomy course grade, Biomechanics/Kinesiology course grade, Exercise Physiology course grade, Musculoskeletal I course grade, overall professional physical therapists education program grade point average (PTGPA), and professional first-year physical therapist education program grade point average (PT1GPA) in relation to NPTE scores. Methods/Description: A retrospective, correlational, quantitative research design was used in this study. Data from 2012 to 2018 graduates of two clinical doctorate physical therapist education programs located at private, non-profit, liberal arts universities in two Midwestern states was analyzed. The focus of the analyses was to investigate any relationships between professional physical therapist education program variables and NPTE scores. Of the 488 admitted students, 467 graduated from either program, but of these graduates, only 432 students released their NPTE scores to the programs and therefore were included in the data set. A multiple regression statistical analysis and two simple regression statistical analyses were conducted. A multiple regression analysis was performed to determine the relationship of physical therapist education program course grade independent variables (Anatomy course grade, Biomechanics/Kinesiology course grade, Exercise Physiology course grade, Musculoskeletal I course grade) to the continuous dependent variable NPTE score. The multiple regression was followed by a stepwise analysis to identify which combination of independent variables yields the highest predictor variable of NPTE score. Two unique simple regression analyses were performed to determine the relationship of PTGPA to NPTE score and to determine the relationship of PT1GPA to NPTE score. Results/Outcomes: All three regression analyses resulted in statistically significant outcomes providing evidence Anatomy course grade, Biomechanics/Kinesiology course grade, Exercise Physiology course grade, Musculoskeletal I course grade, PTGPA, and PT1GPA are predictive of performance on the NPTE. The linear combination of the Anatomy, Biomechanics/Kinesiology, Exercise Physiology, and Musculoskeletal I course grades was significantly related to NPTE score explaining 22.5% of the variance seen (R=0.47, p>0.000). In examining each variable's individual contribution to the combination, Musculoskeletal I course grade was found to have the largest individual contribution (beta=0.204, p>0.000), followed by Exercise Physiology course grade (beta=0.178, p>0.000), Biomechanics/Kinesiology course grade (beta=0.173, p>0.000), and Anatomy course grade (beta=0.120, p>0.015). In conducting the stepwise multiple regression evaluating both the individual contribution of a variable and its influence on the other variables in the model, Exercise Physiology course grade was found to explain 11.7% of the variance seem in NPTE scores (R=0.34, p>0.000). The addition of Musculoskeletal I course grade increased the amount of variance explained to 18.4% (R=0.43, p>0.000), and the addition of Biomechanics/Kinesiology course grade increased it to 21.4% (R=0.46, p>0.000). The first simple regression in this study showed PTGPA to be significantly related to NPTE scores, F (1, 429) = 64.60, p = 0.000, explaining 13.1% of the variance of NPTE scores (r=0.36, p>0.000). The second simple regression in this study showed PTG1PA to be significantly related to NPTE scores, F (1, 430) = 74.47, p = 0.000, explaining 14.8% of the variance of NPTE scores (r=0.38, p>0.000). Discussion: Identifying professional physical therapist education program courses that are highly significant positive predictors of NPTE success expands the ability of a program to intervene with students in risk of low NPTE scores at an even more specific level. Similarly, identifying what components of PT1GPA are predictive of NPTE scores and troublesome for the student is more helpful at ensuring the student gets adequate help in their area of need. This study added to the minute body of research exploring the individual components that comprise the PT1GPA and PTGPA and the impact of foundational physical therapists education program coursework on NPTE scores. Growth of this body of research will give physical therapist education programs another tool to better serve its students, patients, and profession. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]