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An appropriate inflammatory immune response requires the effective orchestration of molecular and cellular effectors. Interleukin-17 (IL-17) is a cytokine, small signaling proteins, made by immune cells to communicate with mainly non-immune cells. IL-17 signaling engages its receptor (IL-17R) to induce inflammation by stabilizing transcripts or by inducing expression of target genes. IL-17R downstream intermediate proteins activate and downregulate intracellular signaling. IL-17R shares some, but not all, intracellular intermediate proteins with Toll-like receptor (TLR) and Tumor necrosis factor α receptor (TNFR) signaling. Previous research has shown that not all intermediates from TLR or TNFR1 pathways participate of IL-17R signaling. We aimed to identify novel intermediate proteins acting downstream in IL-17R by using molecular and cellular biology and biochemical techniques. After identifying five possible novel intermediates that either activate (caveolin-1 and AnapC3) or inhibit (ABIN-1, CYLD, Otulin) IL-17R signaling, we aimed to describe the mechanism of action of two of them, ABIN-1 and caveolin-1. We described the molecular mechanisms by which ubiquitin-binding protein ABIN-1 and membrane-bound scaffolding protein Caveolin-1 control IL-17 signaling. Interestingly, as previous research on other signaling intermediates of IL-17R signaling has shown, IL-17R signaling also regulates the expression of these two proteins in what we propose is a self-modulatory signaling mechanism. Specifically, we identified that ABIN-1 inhibits baseline and IL-17-activated signaling by binding polyubiquitin independently of A20. Moreover, we showed that IL-17 signaling induced degradation of ABIN-1. For caveolin-1, we observed a different mechanism of regulation. Thus, Caveolin-1 interacted with a subunit of IL-17R and regulated trafficking of IL-17R to the cell surface. Interestingly, caveolin-1 regulatory functions correlated with an activating role of caveolin-1 in IL-17R signaling. Lastly, caveolin-1 was downregulated by IL-17 signaling. In this thesis we report novel functions for ABIN-1 and caveolin-1 downstream of IL-17R. These results provide insight into the mechanism by which ABIN-1 and caveolin-1 regulate IL-17R signaling, and how IL-17R signaling self-regulates by modulating the expression or degradation of these two proteins. The results from this thesis contribute to the understanding of IL-17-mediated inflammatory signaling, and set the groundwork for future research on therapies to modulate this inflammatory response.

Vázquez entiende, con Santo Tomás, que si la ley es tomada en un sentido general, es un acto de la razón, supuesto un acto de la voluntad. Una excepción a ese concepto general de la ley es, para Vázquez, lo que se llama ley natural, la cual se identifica con la naturaleza racional del hombre. Y sin embargo, concede que se pueda hablar propiamente de ley con respecto a la ley natural si se entiende que esa ley natural es la misma naturaleza humana.

La profusión de teorías contemporáneas que, sobre la interpretación, se cruzan actualmente en la mesa de un investigador, pueden ocultar el hecho de que los autores tardomedievales o iniciadores de la modernidad, en el Siglo de Oro, también estaban preocupados por lograr correctamente la aplicación de la ley a los casos concretos o de compaginar las distintas leyes entre sí. Y que se debatían entre doctrinas dispares y, al igual que hoy, con gran carga polémica. ¿Quién no tiene todavía presentes los cánones que Friedrich Karl von Savigny (fundador de la escuela histórica alemana del derecho) propuso en el siglo XIX para lograr una interpretación plausible? Él habló de los fines de la interpretación, como también antes lo hicieron, aunque de manera diferente, los hombres del Siglo de Oro. También comentó los varios aspectos o canales de acercamiento al hecho interpretado: el gramatical, el histórico, el sistemático y el teleológico; muchos de estos aspectos ya habían sido objeto de disputa antes incluso del Siglo de Oro. Hasta la expresión “interpretación auténtica” viene de los antiguos glosadores, comentaristas y teólogos que enseñaron en legendarias universidades, como las de Salamanca y Coimbra. El trabajo que aquí presento no pretende abrir un diálogo con las teorías modernas de la interpretación; se limita a perfilar el esfuerzo que uno de aquellos autores, Juan de Salas, hizo para aglutinar los aspectos filosóficos y jurídicos de la interpretación que a principios del siglo XVII eran discutidos en España y que no debiéramos hacerlos desaparecer de nuestra memoria.

Publicación colectiva sobre Ley y dominio en Francisco de Vitoria. Índice de la obra y datos de portada y contraportada.

We propose to analyse shame from a psychological and moral approach. But before that, shame will be analysed both phenomenologically and ontologically. Assessing Straus’s, Scheler’s and Bollnow’s views, we will survey the notion of “transcendental shame” to pave the way for the psychological and moral analysis of shame.

The practical reinterpretation of positive law in the light of its originating principle, oriented to the common good, need neither be a dispensation from the law, nor a discrediting of the legislator, nor a judgment on the law itself, nor an interpretation of said law, but rather it is a virtue, i.e. that of epieikeia. This is made necessary by the fact that a law cannot refer rightly to all cases; in some cases it will fail, and thus the legislator writes the law to cover what occurs in the majority of the cases, without ignoring the fact that in certain cases there will be a failure of the law to apply. This is, according to St. Thomas, that which is contemplated by the epieikeia in order to reinterpret positive law in the light of natural law.

For a Medieval thinker, in addition to positive law, there is another more fundamental law which is known by analyzing our own rational nature and our ultimate end. In this monographic issue, the nature and reach of the natural law will be studied in various medieval authors (St. Augustine, Alcuin of York, Philip the Chancellor, William of Auxerre, St. Bonaventure, St. Thomas Aquinas, John Duns Scotus and William of Ockham).

Cicero’s main philosophical interest is in practical philosophy. This interest stemmed from his legal career and from his political activity. As a result of his philosophy, Greek moral philosophy was received in Latin culture. Cicero is, in his life and his works, the refusal of the moral, anthropological and political nihilism. His ideas, very present in the moral and political philosophy of the Middle Ages, continue being a key for contemporary world views.

Western thought has maintained a permanent attention by the problem of "habere"; even the modern as Marcel and Sartre have taken care of this category. But the contemporary nihilism has put in evidence the necessity to think the dwelling of the concrete existence of the man and its relationship with areas that offer a support to him. There are so many ways to "havere" as potentiality forms, in one of which it express the "habere" like determination ordered to the space in which the man is.

The Aquinate consigns that including in the divine interior, emanation is an order of origin between coincidents or concurrents; in the divine exterior, emanation is an order of origin between incoincidents, be it in the entitative plane (according to the order from essence to existence, and from the faculties to the substance), or be it in the operative plane (according to the order from faculties to act). In this work, only the topics concerned with the entitative level are dealt with, which express two orders of emanation: that of creatures as such and that of the faculties.

Filosofía clásica; filosofía medieval; filosofía moderna. Evolución de las nociones de intelecto, razón y entendimiento a lo largo de la historia de la filosofía.

Unamuno and Ganivet approach the historical fact from romanticism (Ranke and Humboldt), as well as from hegelianism, whose original bond is “Volkgeist”. More exactly, the Ganivet’s concept of “spirit of the territory” is influenced by Hipólito Taine and Unamuno’s concept of “intrahistory” by Spencer. The historical knowledge is leaded by a dialectic between the individual and the universal, similar to dialectic between superficial and deep.

Jornadas sobre Fichte

Estructuralismo; lógica; Hegel; Aristóteles; relación, oposición.

Schelling; idealismo alemán; filosofía positiva.

Filosofía moderna; Schelling; idealismo alemán.

Schiller; romanticismo alemán; elegancia; estética; libertad; gracia; potencia.

Two ethical-social paradigms coexisted in the early Middle Ages: antifeminism and profeminism. The first one expresses the "masculine teleology of creation": the biological primacy belongs to man and therefore, woman is subordinated to him from ontological, psychological and social viewpoints. The second paradigm expresses the "feminine teleology of creation" with its philosophical and juridical repercussions.

Leonardo Polo answers the following questions posed to him by the editor of the Anuario Filosófico: 1) What is the present state of philosophy? 2) What kind of philosophy can be cultivated nowadays? 3) How does one philosophize?

Fichte; idealismo alemán; Absoluto.

Jacobi; Hegel; Heidegger; silencio.

This starting point of the deontological argument as formulated by Millán- Puelles is the absolute imperative of duty on conscience, and its terminus or culmination is God as an Absolute Person. The proof departs from the commanded conscience to the Conscience that commands. An imperative is not only a demand directed toward a free willl, but likewise the demand that one will be directed by another. Each imperative is a dialogue betwen wills. Thence the need that the imperative be imposed ultimately by a person.

Santo Tomás de Aquino; filosofía medieval; lógica; oposición; contrarios; contradictorios.

Historia y libertad; Gehlen; tradición; tradicionalismo.

Ortega y Gasset; filosofía del lenguaje; constitutivos del lenguaje.

Filosofía de la naturaleza

Antropología; fenomenología; egología; autocomprensión

Fenomenología del mito; mito y razón; antropología; desmitización.