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The application of penicillin to the treatment of disease ranks with the improved control of malaria as one of the greatest advances in medicine consolidated during the war years. Gonorrhoea is but one of many infections amenable to the new antibiotics. Therapy of this disease is of special interest not only on account of its present wide prevalence but because of all human afflictions it is perhaps that most responsive to penicillin treatment. This thesis is limited to a consideration of the results reported by others and obtained by myself in male cases with the sodium salt of penicillin. For the sake of clarity in exposition it is divided into fuur main parts. In the first a brief account is given of the properties and mode of action of penicillin upon which treatment is based; the second describes the results obtained by others. The third part is an account of Iv own experiences, clinical and laboratory, of treatment with single aqueous injections. Finally a discussion and summary are presented. (1) Penicillin, its properties, mode of action and application to the treatment of gonorrhoea are described. (2) The results obtained by others are indicated by reference to the literature. (3) Personal observations on the results of treatment by a single injection in aqueous solution are presented, together with the results of blood level estimations. (4) The implications of the foregoing are discussed.