This Special Issue is a selection of the best articles presented at the 18th IEEE International NEWCAS Conference (NEWCAS) 2020 that was held in Montreal, Canada, on June 16–19, 2020. As an Interregional flagship conference of the IEEE Circuits and Systems Society (CASS), this conference covers a wide spectrum of topics, research, and practice in the fields of circuits and systems, and offers an international forum for exchanging ideas and results. [ABSTRACT FROM AUTHOR]