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Global Citizenship Education (GCE) is a topic of relevance in current international educational debates, which increasingly focus on the formation of critical citizenship. This makes it necessary to discover from a critical pedagogical perspective the relationships between this pedagogical approach, Critical Thinking (CT), and GCE. Throughout this study, through an extensive theoretical review of the literature, we try to show the characteristics in which critical pedagogy, GCE, and CT converge, giving rise to the Critical GCE towards which we must move today. Therefore, this study is revealing for discovering the path towards which GCE is currently heading by clearly showing the symbiosis between CT and GCE. In conclusion, if we want to educate global citizens, it is necessary not only to have a strong background in GCE but also to develop CT to understand global society critically and the need to act to try to transform the world into one free from oppression and injustice., Depto. de Didáctica de las Ciencias Experimentales , Sociales y Matemáticas, Fac. de Educación, TRUE, pub

Dichloramine (NHCl2) naturally exists in reverse osmosis (RO) permeate due to its application as an antifouling chemical in membrane-based potable reuse treatment. This study investigated mechanisms of background NHCl2 hydrolysis associated with the generation of oxidative radical species in RO permeate, established a kinetic model to predict the oxidative capacity, and examined its removal efficiency on trace organic contaminants in potable reuse. Results showed that NHCl2 hydrolysis generated transient peroxynitrite (ONOO-) and subsequently dissociated into hydroxyl radical (HO•). The maximal HO• exposure was observed at an RO permeate pH of 8.4, higher than that from typical ultraviolet (UV)-based advanced oxidation processes. The HO• exposure during NHCl2 hydrolysis also peaked at a NH2Cl-to-NHCl2 molar ratio of 1:1. The oxidative capacity rapidly degraded 1,4-dioxane, carbamazepine, atenolol, and sulfamethoxazole in RO permeate. Furthermore, background elevated carbonate in fresh RO permeate can convert HO• to carbonate radical (CO3•-). Aeration of the RO permeate removed total carbonate, significantly increased HO• exposure, and enhanced the degradation kinetics of trace organic contaminants. The kinetic model of NHCl2 hydrolysis predicted well the degradation of contaminants in RO permeate. This study provides new mechanistic insights into NHCl2 hydrolysis that contributes to the oxidative degradation of trace organic contaminants in potable reuse systems.

The construction of a thin, uniform, and robust solid electrolyte interphase (SEI) film on the surface of active materials is pivotal for enhancing the overall performance of lithium-ion batteries (LiBs). However, conventional electrolytes often fail to achieve the desired SEI characteristics. In this work, we introduced 1,3,6-hexanetrinitrile (HTCN) in the baseline electrolyte (BE) of 1.0 M LiPF6 in Ethylene Carbonate/Dimethyl Carbonate (EC/DMC) (3:7 by volume) with 5 wt.% fluoroethylene carbonate (FEC), denoted as BE-FH. By systematically investigating the influence of FEC: HTCN weight ratios on the electrochemical performance of graphite anodes, we identified an optimal composition (FEC:HTCN = 5:4 by weight, denoted as BE-FH54) that demonstrated greatly improved initial Coulombic efficiency, rate capability, and cycling stability compared with the baseline electrolyte. Deviations from the optimal FEC:HTCN ratio resulted in the formation of either small cracks or excessively thick SEI layers. The enhanced performance of BE-FH54-based LiB is mainly ascribed to the synergistic effect of FEC and HTCN in forming a robust, thin, homogeneous, and ion-conducting SEI. This research highlights the importance of rational electrolyte design in enhancing the electrochemical performance of graphite anodes in LiBs and provides insights into the role of nitrile-based additives in modulating the SEI properties.

The active form of vitamin D, 1,25-dihydroxyvitamin D3, is known to act via VDR (vitamin D receptor), affecting several physiological processes. In addition, PDIA3 (protein disulphide-isomerase A3) has been associated with some of the functions of 1,25-dihydroxyvitamin D3. In the present study we used siRNA-mediated silencing of PDIA3 in osteosarcoma and prostate carcinoma cell lines to examine the role(s) of PDIA3 for 1,25-dihydroxyvitamin D3-dependent responses. PDIA3 silencing affected VDR target genes and significantly altered the 1,25-dihydroxyvitamin D3-dependent induction of CYP24A1, essential for elimination of excess 1,25-dihydroxyvitamin D3. Also, PDIA3 silencing significantly altered migration and proliferation in prostate PC3 cells, independently of 1,25-dihydroxyvitamin D3. 1,25-Dihydroxyvitamin D3 increased thermostability of PDIA3 in cellular thermal shift assay, supporting functional interaction between PDIA3 and 1,25-dihydroxyvitamin D3-dependent pathways. In summary, our data link PDIA3 to 1,25-dihydroxyvitamin D3-mediated signalling, underline and extend its role in proliferation and reveal a novel function in maintenance of 1,25-dihydroxyvitamin D3 levels.

BackgroundA growing literature has reported associations between traffic-related air pollution and breast cancer, however there are fewer investigations into specific ambient agents and any putative risk of breast cancer development, particularly studies occurring in populations residing in higher pollution areas such as Los Angeles.ObjectivesTo estimate breast cancer risks related to ambient air toxics exposure at residential addresses.MethodsWe examined the relationships between ambient air toxics and breast cancer risk in the Multiethnic Cohort among 48,665 California female participants followed for cancer from 2003 through 2013. We obtained exposure data on chemicals acting as endocrine disruptors or mammary gland carcinogens from the National-Scale Air Toxics Assessment. Cox proportional hazards models were used to estimate breast cancer risk per one interquartile range (IQR) increase in air toxics exposure lagged by 5-years. Stratified analyses were conducted by race, ethnicity, and hormone receptor types.ResultsAmong all women, increased risks of invasive breast cancer were observed with toxicants related to industries [1,1,2,2-tetrachloroethane (hazard ratio [HR] = 4.22, 95% confidence interval [95% CI] 3.18-5.60), ethylene dichloride (HR = 2.81, 95% CI 2.20-3.59), and vinyl chloride (HR = 2.27, 95% CI 1.81, 2.85); these 3 agents were correlated (r2 = 0.45-0.77)]. Agents related to gasoline production or combustion were related to increased breast cancer risk [benzene (HR = 1.32, 95% CI 1.24, 1.41), ethylbenzene (HR = 1.20, 95% CI 1.13-1.28), toluene (HR = 1.29, 95% CI 1.20-1.38), naphthalene (HR = 1.11, 95% CI 1.02-2.22), acrolein (HR = 2.26, 95% CI 1.92, 2.65)]. Higher hazard ratios were observed in African Americans and Whites compared to other racial and ethnic groups (p-heterogeneity <0.05 for traffic-related air toxics, acrolein, and vinyl acetate).Conclusions

Biocide resistance poses a significant challenge in industrial processes, with bacteria like Pseudomonas oleovorans exhibiting intrinsic resistance to traditional antimicrobial agents. In this study, the impact of biocide exposure on the metabolome of two P. oleovorans strains, namely, P. oleovorans P4A, isolated from contaminated coating material, and P. oleovorans 1045 reference strain, were investigated. The strains were exposed to 2-Methylisothiazol-3(2H)-one (MI) MIT, 1,2-Benzisothiazol-3(2H)-one (BIT), and 5-chloro-2-methyl-isothiazol-3-one (CMIT) at two different sub-inhibitory concentrations and the lipids and polar and semipolar metabolites were analyzed by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry UPLC-Q-TOF/MS. Exposure to the BIT biocide induced significant metabolic modifications in P. oleovorans. Notable changes were observed in lipid and metabolite profiles, particularly in phospholipids, amino acid metabolism, and pathways related to stress response and adaptation. The 1045 strain showed more pronounced metabolic alterations than the P4A strain, suggesting potential implications for lipid, amino acid metabolism, energy metabolism, and stress adaptation. Improving our understanding of how different substances interact with bacteria is crucial for making antimicrobial chemicals more effective and addressing the challenges of resistance. We observed that different biocides trigged significantly different metabolic responses in these strains. Our study shows that metabolomics can be used as a tool for the investigation of metabolic mechanisms underlying biocide resistance, and thus in the development of targeted biocides. This in turn can have implications in combating biocide resistance in bacteria such as P. oleovorans., This research has received funding from SAINT-GOBAIN SWEDEN AB, SCANSPAC.

Anthropogenic activities are causing detrimental changes to coastal plants– namely seagrass, mangrove, and tidal marshes. Looking beyond recent times to past vegetation dynamics is critical to assess the response and resilience of an environment to change. Here, we develop a high-resolution multi-proxy approach, providing a new evidence base to decipher long-term change in coastal plant communities. Combining targeted environmental DNA analysis with chemical analysis of soils, we reconstructed 4,000 years of change at a temperate wetland on Torrens Island South Australia and identified an ecosystem shift that occurred ~ 1000 years ago. What was once a subtidal seagrass system shifted to an intertidal mangrove environment that persists at this site today. We demonstrate that high-resolution historical changes in coastal vegetation can be attained using these proxies. This approach could be applied to other ecosystems to improve the way we protect, conserve, and restore vegetated ecosystems.

La biología sintética es una disciplina emergente preñada de promesas. El principal objetivo en su agenda de investigación es sentar las bases para convertir la biología en objeto de ingeniería y fabricar organismos que respondan a propósitos humanos. De este modo, la biología sintética se revelaría una pieza clave para implantar el modelo de bioeconomía promulgado por la UE y la OCDE. De ella se espera toda una nueva gama de aplicaciones y productos industriales, pero también respuestas que ayuden a frenar el cambio climático y a contrarrestar la dependencia de combustibles fósiles con tecnologías “verdes”. El presente artículo pretende ofrecer algunas coordenadas para entender el contexto en el que surgen estas promesas en el marco de un horizonte de crisis., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

La expansión del terrorismo yihadista se plantea como uno de los problemas más graves de la política internacional. Para comprender sus raíces y orígenes conceptuales es necesario echar una mirada a la teoría del filósofo y jurista Carl Schmitt. Schmitt dedicó parte de su obra al estudio del fenómeno partisano o guerrillero. Tal y como él explica, los partisanos emergieron en el siglo xix y se caracterizaron por su irregularidad, su movilidad y su carácter político y telúrico. Con el desarrollo de la técnica y en el contexto de lucha bipolar los partisanos del siglo xx irían perdiendo la contención que les caracterizaba inicialmente. Existe un debate acerca de si el terrorista del siglo xxi es la evolución de dichos partisanos o si, por el contrario, constituye una figura diferente. Para dar respuesta a ello comparo en este artículo, desde la perspectiva teórica de Carl Schmitt, los rasgos propios del yihadista con los del guerrillero., The expansion of jihadist terrorism is considered one of the most serious problems of international politics. In order to understand its roots and conceptual origins it is necessary to take a look at the theory of the philosopher and jurist Carl Schmitt. Schmitt devoted part of his work to the study of the partisan or guerrilla phenomenon. As he explains, the partisans emerged in the 19th century and they were categorized by their irregularity, their mobility and their political and telluric nature. With the development of the technique and in the context of the bipolar struggle, the partisans of the 20th century would lose the restraint which characterized them initially. There is a debate about whether the terrorist of the 21st century appears as the evolution of these partisans or if, on the contrary, it constitutes a different figure. To answer this question I compare in this article, from the theoretical perspective of Carl Schmitt, the traits of the jihadist with those of the guerrilla., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

Número dedicado a: Nacionalismos: teorías y prácticas, coordinadores: Juan José Gómez Gutiérrez y Esteban Anchústegui Igartua, El pensamiento baazista, desarrollado e institucionalizado por Michel Aflaq y Salah ad-Din al-Bitar alrededor de 1940, gobernó durante décadas en Irak y en Siria. Únicamente en este último país sigue vigente, pues tras la invasión estadounidense de Irak en 2003 y la caída del régimen de Sadam Husein, el baazismo iraquí desapareció como ideología hegemónica. Para comprender la enjundia filosófico-política de este movimiento es necesario desgranar sus conceptos clave, esto es, la unidad, el socialismo y el laicismo, para así explicar qué tipo de nación se pretendía construir a través de esta teoría, también denominada socialismo árabe., The Baathist thinking, developed and institutionalized by Michel Aflaq and Salah adDin al-Bitar around 1940, ruled for decades in Iraq and Syria. Only in the latter is still in force, as after the US invasion of Iraq in 2003 and the fall of Saddam Hussein's regime, the Iraqi Baathism disappeared as a hegemonic ideology. To understand the philosophical-political background of this movement, it is necessary to explain its key concepts, unity, socialism and secularism, in order to explain what kind of nation was intended to be built through this theory, also called Arab socialism., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

Introducción "¿Para qué Estado?" y traducción de “Ética de Estado y Estado pluralista”, de Carl Schmitt (1930)., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

This paper presents an interpretation of Marx’ critique of political economy articulated around the concepts of fetichism and mystification understood as forms of appearance. According to the thesis proposed, far from being mere rethorical resources or rests from remains of a bad idealist philosophy, make out a constitutive and fundamental part of the theoretical core of Marx’ mature work. After a discussion of the meaning of both concepts and their forms as forms of appearance, we will try to show the architectonic meaning function that both concepts hold for the internal structure of the critique of political economy. In particular, we shall present the concept of fetichism as crucial for the understanding of Marx’ value theory, and that of mystification as a central one for what can be designed as a surplus value theory, a concept which is also central to the whole conceptual developments in of books I and III of Capital., En este artículo se presenta una interpretación de la crítica de la economía política de Marx articulada sobre los conceptos de fetichismo y mistifica-ción entendidos como formas de apariencia. Se sostendrá la tesis de que estos conceptos, lejos de consistir, como a veces ha sostenido la tradición marxista, en meros recursos retóricos o vestigios de una mala filosofía idealista, componen, como conceptos de pleno derecho, una parte constitutiva y fundamental del núcleo teórico de la obra madura de Marx. Tras presentar el significado de ambos conceptos y sus formas como formas de apariencia, trataremos de mostrar el valor, consideramos, arquitectónico que ambos conceptos guardan para la estructura interna de la crítica de la economía política. En concreto, consideramos que el concepto de fetichismo es central para comprender la teoría del valor de Marx, y el de la mistificación, para aquello que podemos llamar teoría del plusvalor y que abarca todo el desarrollo conceptual restante de los libros I y III de El capital., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

Artículo incluido en el monográfico: "Fronteras, democracia y justicia global"., Todo cambio geopolítico representa la creación de un nuevo orden y ello conlleva la alteración de las condiciones espaciales y, por tanto, la modificación de la manera de entender las fronteras. Carl Schmitt, especialmente en su última etapa, apuntó al delineamiento de una nueva configuración internacional conformada por grandes espacios (Grossräume), una vez que el tiempo de las soberanías propias del Ius publicum europaeum había terminado. El objetivo de este estudio es analizar hasta qué punto y de qué manera las herramientas analíticas de Schmitt en torno a las fronteras pueden ser útiles para comprender el estado actual de la globalización., All geopolitical change represents the creation of a new order and this entails the alteration of the spatial conditions and, therefore, the modification of the way of understanding borders. Carl Schmitt, especially in his last stage, aimed at delineating a new international configuration made up of large spaces (Grossräume), once the time of sovereignties typical of the Ius publicum europaeum was over. The goal of this study is to analizy to which extent and how Schmitt ‘s analytical tools around borders can be useful to understand the current state of globalization., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

The paper argues that the large extent of disinformation has increased the number of deaths from coronavirus due to the proliferation of hoaxes spread via digital tools and media. It is noted that this problem could worsen in the post-COVID society and as such should be understood as having significant political import. Moreover, the phenomenon of disinformation has raised ethical questions around how to actively prevent deaths indirectly caused by hoaxes, as well as epistemological questions around maintaining criteria of truthfulness., Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

García-Arnaldos, M. D. (2018). “Cooperación y fraternidad civil”. Daimon. Revista Internacional De Filosofia, 175-189. https://doi.org/10.6018/daimon/334021 Clasificación CIRC: Segundo cuartil (B). ICDS = 10.0, La crisis en la que estamos inmersos tiene entre sus causas una profunda crisis de relaciones entre las personas y los Estados. Si superamos esta crisis de relaciones, asumiendo nuevos paradigmas políticos y sociales, aseguraremos la base de una nueva convivencia democrática, integradora y solidaria, que responda al reto de la globalización y la interdependencia. Sólo se saldrá de la crisis de relaciones desde valores basados en la solidaridad, asentada en la confianza mutua. Algunas propuestas para regenerar el sistema de valores apelan el paradigma de la fraternidad: la globalización de la solidaridad como respuesta a la crisis de la globalización., Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

Artículo incluido en el número dedicado a: "Economía"., El presente texto aspira a presentar algunas de las tesis fundamentales de Robert Kurz (1943-2012) sobre el capital mundial en la era de crisis del capitalismo. Kurz fue el teórico fundamental de una corriente teórica de teoría y crítica del capitalismo que se presenta con el nombre de “crítica del valor”, y que se articuló en Alemania a partir de finales de la década de 1980 en torno a las revistas “Krisis” y, desde 2005, “Exit!”. Sus textos fueron decisivos a la hora de plantear una reinterpretación de las categorías marxianas que, más allá de los planteamientos del marxismo tradicional que piensa el capitalismo fundamentalmente desde la contradicción entre capital y trabajo, intentaba analizar el lugar específico de la formación capitalista en la historia y la propia historia del capitalismo. El resultado fue un replanteamiento de la teoría y la crítica de la sociedad capitalista., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

El artículo explora las nuevas formas de organizar lo social desde la clave de la hibridación. El objeto de reflexión se sitúa en las articulaciones entre lo público y lo privado en el escenario de las narraciones blográficas. En concreto se centra en el movimiento de lo público a lo privado y en las transformaciones resultantes, proponiendo dos lecturas contrapuestas denominadas: espectacularización y politización. En el desarrollo del estudio se toma como base una encuesta realizada ad hoc sobre los usos de los blogs y se analiza semióticamente un corpus seleccionado de blogs personales., Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

The aim of this paper is to determine the role, not always unambiguous, that Karl Marx plays in Hannah Arendt’s endeavour of outlining a thought of the political free from metaphysical categories. Both a modern thinker of labour, History and violence, and at the same time the last tie to the forgotten Greek, pre-philosophical experience of the political, the keys of the Arendt’s dialogue with Marx help to illuminate Arendt’s own theoretical project., El objetivo de este artículo es precisar el papel, no exento de ambigüedades, que Karl Marx juega en el intento de Hannah Arendt de trazar un pensamiento de lo político no secuestrado por las categorías de la metafísica. Tan pronto pensador moderno del trabajo, la historia y la violencia, como último lazo con la olvidada experiencia griega, pre-filosófica de lo político, las claves del diálogo de Arendt con Marx permiten iluminar el propio proyecto teórico de la pensadora., Ministerio de Ciencia e Innovación, Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

STUDIA SEMIOTYCZNE, t. XXXIII, nr 1 (2019), s. 29–47 ISSN 0137-6608, e-ISSN 2544-073X Clasificación CIRC: Segundo cuartil (B); ICDS = 10.0, A priori theories of justification of logic based on meaning often lead to trouble, in particular to issues concerning circularity. First, I present Boghossian’s a priori view. Boghossian maintains the rule-circular justifications from a conceptual role semantics. However, rule-circular justifications are problematic. Recently, Boghossian (Boghossian, 2015) has claimed that rules should be thought of as contents and contents as abstract objects. In this paper, I discuss Boghossian’s view. My argumentation consists of three main parts. First, I analyse several arguments to show that in fact, Boghossian’s inferentialist solution is not fully satisfying. Second, I discuss the matter further, if one accepts that basic logical rules are constitutive of meaning, that is, they constitute the logical concepts and the content of a rule is an abstract object, then abstract objects—like, for example, rules—could be constitutive of meaning. The question is whether conceptual priority is in the judgment or in the object and what theory of content is pursued. Grasping content as a matter of knowing how a word or concept behaves in inferences is not completely explicative. Finally, I contend that rules come to exist as a result of certain kinds of mental action. These actions function as constitutive norms. Logical rules are not abstract objects but ideal. What one construes as norms or rules of content may involve idealization, but this is because we share a language., Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

The consensus today is that both Newton and Leibniz created calculus independently. Yet, this was not so clear at the beginning of the eighteenth century. A bitter controversy took place at that time, which came to be known as the ‘calculus war’, probably the greatest clash in the history of science. While it is accepted that the debate started when Fatio de Duillier publicly accused Leibniz of plagiarism in 1699, earlier evidence of its origins can be found in an exchange of letters between Leibniz and Huygens., Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

En la teoría internacional de Carl Schmitt la configuración política está condicionada por el espacio. Si bien el esquema de la Modernidad, articulado en torno a los diferentes tipos de guerra que surgían de la dicotomía tierra-mar, queda alterado con la incorporación de la aviación, será el uso de drones lo que pondrá en entredicho las nociones mismas de «campo de batalla», «soldado» o «enemigo». La realidad del dron desborda las coordenadas schmittianas, pero estas pueden servir como punto de partida para comprender cómo el espacio determina la guerra contemporánea., In Carl Schmitt’s international thought the political configuration is conditioned by space. Even though the blueprint of Modernity, articulated around the different politics that emerged from the land-sea dichotomy, rested altered with the incorporation of aviation, it will be the use of drones which will cast serious doubts on the notions of «battleground», «soldier» or «enemy». The reality of drones overflows the Schmittian coordinates, nevertheless they can be useful as starting point in order to understand how space determines contemporary war., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

Desde la polémica mantenida entre Jacobi y Mendelssohn en 1785 sobre el supuesto spinozismo de Lessing, se ha considerado que sis-tema de razón, fatalismo y panteísmo (y con él el spinozismo como forma más perfecta) constitu-yen una tríada de conceptos inseparables, de ahí la afirmación clave de Schlegel en el Indierbuch: «der Pantheismus ist das System der reinen Ver-nunft» (KA VIII, 249; Cit. por Schelling en SW I/VII 339, n. a; 117). De esta manera, Schelling no deja de ser un «vástago» del Pantheismusstreitde Mendelssohn y Jacobi: una polémica cuyo fantasma, personificado por Schlegel, aparecerá entre las páginas del Freiheitsschrift., Since the controversy held between Jacobi and Mendelssohn in 1785 about the assumption Spinozism of Lessing, has been considered that system of reason, fatalismandpantheism (and with it Spinozism as the most perfect way) constitute a triad of inseparable concepts, hence the assertion key of Schlegel in Indierbuch: «der Pantheismus ist das System der reinen Vernunft» (KA VIII, 249; Qu. by Sche-lling in SW I/VII 339, n. a; 117). In this way, Schelling is within Mendelssohn and Jacobi’s Pantheismusstreit: a controversy whose ghost, personified by Schlegel, appears in the pages of Freiheitsschrift, Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

Artículo incluido en el número dedecado a: "Teoría Crítica de la industria cultural", Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

Artículo incluido en el ejemplar dedicado a: Idealismo y Romanticismo: "Derivas" contemporáneas, El primer artículo presenta un análisis de la serie de televisión American Horror Story (Temporada 1) en la que los elementos angustiosos del terror quedan compenetrados a través de la fusión de lo sublime y lo siniestro ante lo «impensable» e «irrepresentable», acudiendo a muchos de los motivos que fueron expuestos por los románticos en estrecha relación con lo sublime kantiano ante el papel de la Naturaleza frente al Yo y el abismamiento de éste a través de lo más familiar: la casa. Las ideas de fracaso de la razón moderna y del carácter constitutivo de los elementos oscuros a través del Yo, a los que se puede acceder a través del sueño o de la muerte o en los momentos de crepúsculo o amanecer, característicos del Romanticismo quedan así relacionadas con las formas contemporáneas para generar una mitología del terror., Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

There is broad consensus on the need to foster oral skills in middle school due to their inherent importance and because they serve as a tool for learning and acquiring other competences. In order to facilitate the assessment of communicative competence, we hereby propose a model which establishes five key dimensions for effective oral communication: interaction management; multimodality and prosody; textual coherence and cohesion; argumentative strategies; and lexicon and terminology. Based on this model, we developed indicators to measure the proposed dimensions, thus generating a self-report tool to assess oral communication in middle school. Following an initial study conducted with 168 students (mean age = 12.47 years, SD = 0.41), we selected 22 items with the highest discriminant power, while in a second study carried out with a sample of 960 students (mean age 14.11 years, SD = 0.97), we obtained evidence concerning factorial validity and the relationships between oral skills, emotional intelligence and metacognitive strategies related to metacomprehension. We concluded that the proposed model and its derived measure constitute an instrument with good psychometric properties for a reliable and valid assessment of students’ oral competence in middle school., Ministerio de Ciencia, Innovación y Universidades, Depto. de Psicología Experimental, Procesos Cognitivos y Logopedia, Fac. de Psicología, TRUE, pub

El presente trabajo ha sido llevado a cabo gracias a la obtención de una Ayuda Juan de la Cierva-formación (2017) número FJCI-2017-32068, concedida por el Ministerio de Ciencia, Innovación y Universidades (España). This work was supported by the Ministry of Science and Innovation of the Spanish Government: [grant Juan de la Cierva-Formación (2017) number FJCI-2017-32068]., This paper focuses on Leo Strauss’s reading of the Republic. I argue that Strauss’s ironic interpretation of the dialogue must be understood in the context of a broader intellectual project which aims to criticize modern and contemporary political philosophy. Strauss’s understanding of Plato is strongly influenced by the hermeneutical principles he draws from his studies of medieval Jewish and Arab philosophy. Reading Plato through Alfarabi, Strauss pursues the idea of the conflict between philosophy and politics, which sheds light, also, on the problem of persecution. Accordingly, he stresses the importance of a peculiar art of reading between the lines. In Strauss’s view, this art is the starting point for recovering the esoteric meaning of the Republic. I will argue that Strauss’s interpretation contradicts several dialogical elements because it does not take into account the broader historical framework of the text. Nevertheless, even with these limitations, Plato scholars should consider Straussian insights, because these offer an untraditional and a non-doctrinal reading of the dialogue., Ministerio de Ciencia e Innovación (España), Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

El presente trabajo ha sido llevado a cabo gracias a la obtención de una Ayuda Juan de la Cierva-formación (2017) concedida por el Ministerio de Ciencia, Innovación y Universidades y la consecuente incorporación en el Grupo de investigación “Historia y ontología del presente: la perspectiva hispana” (GIPEL) de la Universidad Complutense de Madrid, dirigido por el Prof. José Luis Villacañas Berlanga., Throughout the philosophical tradition that stems from Plato, Socratic irony has represented an enigma that all interpreters of the Platonic dialogues have had to face from different points of view. In this article I aim to present the peculiar Straussian reading of Socratic irony. According to Leo Strauss, Socratic irony is a key element of Plato’s political philosophy, linked to the «logographic necessity» that rules his texts. I will therefore examine the genesis and the main features of Straussian hermeneutics. I will end the article by highlighting the relevance of the esoteric interpretation of Platonic thought as a conceptual tool that responds to the crisis of modern political philosophy., A lo largo de la tradición filosófica la ironía de Sócrates ha representado un enigma con el que han tenido que confrontarse, desde distintos puntos de vista, todos los intérpretes de los diálogos platónicos. En este artículo presentaremos la original lectura straussiana de la ironía socrática. Según Leo Strauss, la ironía de Sócrates es un elemento clave de la filosofía política de Platón, vinculado con la «necesidad logográfica» que gobierna sus textos. Examinaremos, por tanto, la génesis y los rasgos principales de la hermenéutica straussiana y, finalmente, destacaremos la relevancia de la interpretación esotérica del pensamiento platónico en tanto que herramienta conceptual para responder a la crisis de la filosofía política moderna., Ministerio de Ciencia, Innovación y Universidades (España), Depto. de Filosofía y Sociedad, Fac. de Filosofía, TRUE, pub

García-Arnaldos, M. D. (2021). Responsabilidad y compromiso cívico. Estudios de Filosofía. Nº 63, 151-167. https://doi.org/10.17533/udea.ef.n63a08 Clasificación C en CIRC - ICDS = 6.5, El compromiso cívico favorece la integración y la cohesión social, pero el modo en que esto ocurre y el papel que la responsabilidad juega en estos procesos requiere un detenido análisis. A partir de los comentarios críticos de Arendt sobre el vínculo entre la ciudadanía y los derechos, la concepción de Weil de las obligaciones hacia el ser humano y, la reflexión de Zambrano sobre Europa, se sostiene que es preciso promover la cooperación y no solo las obligaciones. Una forma posible es revalorizar el papel de la empatía en su importante función social, ya que refuerza las relaciones sociales; pero no es suficiente. Se afirma que es necesario asumir nuevos paradigmas políticos y sociales, como el de la solidaridad o la fraternidad, para forjar un nuevo pacto social que promueva el compromiso cívico en los espacios sociales, económicos y políticos., Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

La educación centrada en el aprendizaje es uno de los principios de la Universidad Autónoma de la Ciudad de México (UACM) el cual no se ha podido consolidar debido a la persistencia del enfoque de enseñanza basado en la clase magistral, entre otras causas. La propuesta de la Enseñanza para la comprensión (EpC), elaborado por el proyecto Zero de la Universidad de Harvard, propone un marco de trabajo para diseñar unidades temáticas que involucren activamente a los estudiantes al alinear metas de comprensión con actividades de desempeño y una evaluación formativa continua. En este artículo se presenta la descripción cualitativa del trabajo exploratorio de un grupo de profesores de Matemáticas, Física e Informática del Ciclo Básico de las carreras del Colegio de Ciencia y Tecnología de la UACM en el diseño de actividades basadas en la EpC. Como conclusión, se encuentra que la EpC es una metodología que permite desarrollar recursos de aprendizaje activo a través de un trabajo de colaboración colegiado, que puede permitir desarrollar puentes entre diferentes cursos y apoyar el aprendizaje integral en la formación básica de un ingeniero.

This research aims to present the results of implementing a compendium of activities and Interactive Lecture Demonstrations based on PhET Interactive Simulations. The implementation of the compendium was tested in two pilot groups in the Conceptual Physics course, during the August-December 2021 semester. The student's responses to the activity sheets and the Interactive Lecture Demonstrations sheets were analyzed. The results of the study show that the implementation had a good acceptance among the groups of students and the follow-up study of a sample of students suggests a progressive improvement in their predictions. The conclusions derived from the study identify the areas of opportunity to improve the worksheets and help to obtain different perspectives on the diagnosis of the conceptual bases of the new student body, both helpful in the improvement and redesign of the compendium., Esta investigación tiene como objetivo presentar los resultados de la implementación de un compendio de Hojas de Actividades y Clases Interactivas Demostrativas basadas en los simuladores interactivos PhET. La implementación del compendio fue puesta a prueba en dos grupos piloto en la asignatura de Física Conceptual durante el semestre agosto-diciembre 2021 en la Universidad Autónoma de Ciudad Juárez. Se realizó un análisis de las respuestas de los grupos de estudiantes a las hojas de actividades y a las predicciones de las hojas de Clases Interactivas Demostrativas contenidas en el compendio. Los resultados del estudio muestran que la implementación tuvo una buena aceptación entre los grupos de estudiantes y el estudio de seguimiento de una muestra de estudiantes sugiere una mejora progresiva en sus predicciones. Las conclusiones derivadas del estudio identifican las áreas de oportunidad para la mejora de las hojas de trabajo y ayudan a obtener diversas perspectivas sobre el diagnóstico de las bases conceptuales del estudiantado de nuevo ingreso, ambas útiles en la mejora y rediseño del compendio.

Este artículo forma parte de un número especial de Spatial Statistics and Operational Research for Wildfires Management, Wildfires are recurrent natural events that have been increasing in frequency and severity in recent decades. They threaten human lives and damage ecosystems and infrastructure, leading to high recovery costs. To address the issue of wildfires, several activities must be managed and coordinated in order to develop a suitable response that is both effective and affordable. This includes actions taken before (mitigation, prevention, and preparedness), during (response), and after the event (recovery). Considering the available resources and the safety of the involved personnel is a key aspect. This article is a review focused on fire suppression, which comprises actions belonging to the preparedness phase (deployment) and the response phase (dispatching) of the wildfire management scheme. It goes through the models and methodologies that, applying operations research and optimization techniques, address the management of resources to address fire suppression. This article presents a review of the studies published after the last review on the topic in 2017, but also includes some interesting papers before that date. It concludes with some classifying tables and a few conclusions about possible future lines of research., Depto. de Estadística e Investigación Operativa, Fac. de Ciencias Matemáticas, Instituto de Matemática Interdisciplinar (IMI), TRUE, pub

The construction of duocarmycin-like compounds is often associated with lengthy synthetic routes. Presented herein is the development of a short and convenient synthesis of a type of duocarmycin prodrug. The 1,2,3,6-tetrahydropyrrolo[3,2-e]indole-containing core is here constructed from commercially available Boc-5-bromoindole in four steps and 23% overall yield, utilizing a Buchwald-Hartwig amination followed by a sodium hydride-induced regioselective bromination. In addition, protocols for selective mono- and di-halogenations of positions 3 and 4 were also developed, which could be useful for further exploration of this scaffold.

Biological processes take place through interactions between macromolecules, such as nucleic acids and proteins. It is, therefore, fundamental to understand the functions of proteins and how they form complexes in order to carry out their role. Importantly, including spatial information in the analyses of protein complexes allows us to account for cell or tissue heterogeneity, highlighting the importance of in situ studies in biologically and clinically relevant material. To that end, methods for the analysis of protein complexes in situ have been developed, such as in situ proximity ligation assay (PLA) and proximity-dependent initiation of hybridisation chain reaction (proxHCR). Both methods depend on antibodies for target recognition and utilise oligonucleotide systems in order to generate reporter signals with fluorescence readout. While in situ PLA employs rolling circle amplification, proxHCR is an enzyme-free method that takes advantage of DNA hybridisation properties. Both methods, however, yield a polymerised reporter signal of protein complex formation. To further the use of proxHCR, we optimised the design of the oligonucleotide system as well as the experimental procedure, so as to increase the robustness and versatility of the assay. In addition, we developed a novel method, MolBoolean, that simultaneously reports the levels of free proteins as well as protein complexes. In this way, we address limitations of earlier methods and provide the opportunity to obtain a more comprehensive picture of biological processes. Our methods provide a means to circumvent the resolution limits of light microscopy by utilising molecular tricks so that protein binding events, that occur below the resolving power of conventional instrumentation, are made visible. The methods presented in the present doctoral thesis provide powerful tools in the analysis of protein interactions and have applications in cell biology studies as well as in diagnostics. Part of this thesis

En este artículo se analiza la Gestión de los Recursos Hídricos en el municipio de Culiacán, Sinaloa, México. Para el análisis se considera la relación de la gestión del agua con la sustentabilidad económica, social y medioambiental, partiendo de que la apropiada implementación de una Gestión Integral de Recursos Hídricos Municipales (GIRHMU) debe resultar en una disponibilidad de agua compatible con los Objetivos del Desarrollo Sostenible. Se presenta el contexto territorial del municipio en relación con los recursos hídricos, también una medición cuantitativa de la oferta y demanda de agua (balance hídrico) relacionándolas con el crecimiento demográfico y el cambio climático. Se encontró que no existe una garantía para la oferta futura del agua, que la distribución de agua entre los distintos usos no es proporcional ni adecuada y que no hay una estrategia definida de adaptación a los potenciales peligros del cambio climático.

A kinetic model derived from a simplified reaction sequence is proposed for the photo-Fenton degradation of Paracetamol (PCT), employing an annular photoreactor. The kinetic model explicitly included the effects of radiation absorption on pollutant degradation kinetics through the evaluation of the Local Volumetric Rate of Photon Absorption (LVRPA). Irradiated experiments achieved an average PCT conversion of 99.3% at 5 min of reaction, and a maximum of 69% of mineralization. Conversely, non-irradiated experiments reached an average PCT conversion of 86.6% at 5 min of reaction, and a maximum of 35% of mineralization. Kinetic parameters (, ,M-1s-1) were estimated employing a nonlinear, multi-parameter regression method, and the validated kinetic model was used to predict temporal variations of the concentrations of HP, PCT, and the main reaction intermediates: hydroquinone (HQ) and 1,4-benzoquinone (BQ). The root mean square error (RMSE) values obtained for HP, PCT, HP, HQ and BQ were 1.16¿×¿10-2, 7.13¿×¿10-1, 3.53¿×¿10-3, 3.05¿×¿10-3 mM, respectively, showing a good agreement between experimental and predicted data. Moreover, the kinetic model was validated with a new set of experimental tests, confirming its predictive capacity. Beyond the degree of mineralization attained, additional cytotoxicity tests proved that the photo-Fenton process is effective in generating a non-toxic effluent under the operating variables investigated., Peer Reviewed, Postprint (published version)

Background Recent studies have indicated that a high-fat diet (HFD) and/or HFD-induced obesity may influence prostate cancer (PCa) progression, but the role of HFD in PCa microenvironment is unclear. This study aimed to delineate the molecular mechanisms of PCa progression under HFD milieus and define the stromal microenvironment focusing on macrophage inhibitory cytokine-1 (MIC-1) activation. Methods We investigated the effects of HFD on PCa stromal microenvironment and MIC-1 signaling activation using PC-3M-luc-C6 PCa model mice fed with HFD or control diet. Further, we explored the effect of periprostatic adipocytes derived from primary PCa patients on activation and cytokine secretion of prostate stromal fibroblasts. Expression patterns and roles of MIC-1 signaling on human PCa stroma activation and progression were also investigated. Results HFD stimulated PCa cell growth and invasion as a result of upregulated MIC-1 signaling and subsequently increased the secretion of interleukin (IL)-8 and IL-6 from prostate stromal fibroblasts in PC-3M-luc-C6 PCa mouse model. In addition, periprostatic adipocytes directly stimulated MIC-1 production from PC-3 cells and IL-8 secretion in prostate stromal fibroblasts through the upregulation of adipose lipolysis and free fatty acid release. The increased serum MIC-1 was significantly correlated with human PCa stroma activation, high serum IL-8, IL-6, and lipase activity, advanced PCa progression, and high body mass index of the patients. Glial-derived neurotrophic factor receptor alpha-like (GFRAL), a specific receptor of MIC-1, was highly expressed in both cytoplasm and membrane of PCa cells and surrounding stromal fibroblasts, and the expression level was decreased by androgen deprivation therapy and chemotherapy. Conclusion HFD-mediated activation of the PCa stromal microenvironment through metabolically upregulated MIC-1 signaling by increased available free fatty acids may be a critical mechanism of HFD and/or obesity-in

Microporous polyureas can be highly stable, but isocyanates or phosgene are normally used for the synthesis. Here, it was postulated and demonstrated that 1,1′-carbonyl diimidazole (CDI) could be used for the synthesis. By reacting tetrakis(4-aminophenyl)methane with CDI, a series of new polyureas with ultramicropores (pores <0.7 nm) were synthesized. To tailor thermal properties and porosity, the ratio of tetraamine-to-CDI and the reaction temperature were varied. The CO2 adsorption capacities (with values up to 0.74 mmol/g at 0.15 bar/273 K and 1.91 mmol/g at 1 bar/273 K) were ascribed to the ultramicroporosity. The CO2-based Dubinin-Radushkevich surface areas reached 395 m2/g (at 273 K), while the N2-based BET surface areas (at 77 K) were small. The apparent CO2-over-N2 selectivity was also high for the polymers at 273 K with estimated values of 31–92 for 15/85 v/v mixtures of CO2 and N2. This high selectivity was ascribed to the kinetic hindrance of N2 diffusion. It was noted that one of the polymers changed color irreversibly upon heating. In conclusion, it was shown that CDI and amines could be used to synthesize ultramicroporous polyureas, and that these polymers can exhibit irreversible thermochromism. This thermal effect was attributed to the electron-rich urea moieties, aromatic units, and conjugation.

Contains fulltext : 296425.pdf (Publisher’s version ) (Open Access)

The biodiesel sector has witnessed tremendous growth in recent years, leading to a significant increase in glycerol production as a by-product. Addressing the challenge of glycerol valorization is crucial for the sustainability of the biodiesel industry. One promising solution is the conversion of glycerol into more valuable chemicals, such as 1,3-propanediol (1,3-PDO). Microorganisms offer several advantages for this conversion process, including their diverse metabolic pathways and enzymatic capabilities. Key enzymes involved in the 1,3-PDO production pathway include glycerol dehydratase (GDHt), glycerol dehydratase reactivase (GDHtR), and 1,3-propanediol dehydrogenase (1,3-PDDH). The aim of the present research project was to bio-transform glycerol into 1,3-propanediol by cloning and expressing GDHt and 1,3-PDDH in E. coli. Additionally, the specific activity of GDHt enzyme and the necessity of GDHtR were investigated. The selected genes dhaB, orfX, and orfZ from Klebsiella pneumoniae were utilized for the synthesis of GDHt, GDHtR, and 1,3-PDDH, respectively. Initial measurements of GDHt’s activity revealed detectable levels, which increased upon the addition of GDHtR, indicating the influence of GDHtR on GDHt's activity. However, the interpretation of activity values is complicated by potential interferences from aldehydes or metabolites present in crude cell extracts. To address these complexities, enzyme assays using purified enzymes were performed, but no statistically significant data were obtained. Further investigations are required to optimize the measurement of GDHt activity and address the potential influence of the cofactor B12. Coexpression of GDHt and 1,3-PDDH enzymes, resulted in a reduction of cofactor NADH, indicating the potential conversion of glycerol into 1,3-PDO. Nevertheless, the formation of the product could not be detected, and the decline in NADH could not be solely attributed to the coupled-enzymatic reaction. Additional investigations, The production of biodiesel, a type of renewable fuel, has been increasing rapidly, leading to a significant increase in the production of glycerol by-product. Scientists are now looking for ways to use this excess glycerol in a sustainable manner. One exciting solution is to convert glycerol into a valuable chemical called 1,3-propanediol (1,3-PDO). 1,3-PDO is a valuable compound with various applications in industries like manufacturing, textiles, and cosmetics. It can be used to make polyester fibers, which are used in clothing and fabrics, as well as in the production of personal care products like lotions and creams. This conversion process of glycerol into 1,3-PDO can be done by using microorganisms, like bacteria, which have special abilities to transform glycerol into 1,3-PDO. To make this conversion happen, certain enzymes are involved. Enzymes are special proteins which help carry out specific chemical reactions inside the cells. In the case of glycerol transformation, two key enzymes are responsible for the process: glycerol dehydratase (GDHt) and 1,3-propanediol dehydrogenase (1,3-PDDH). Here's how the transformation of glycerol into 1,3-PDO occurs: First, GDHt takes glycerol and converts it into a different chemical called 3-hydroxypropionaldehyde (3-HPA). Next, 3-HPA goes through another reaction facilitated by 1,3-PDDH, resulting in the formation of 1,3-PDO. In this research project, these two enzymes were used to transform glycerol into 1,3-PDO. The focus was on studying GDHt and 1,3-PDDH enzymes and how they work together. A common bacterium called Escherichia coli (E. coli) was used, and the genes responsible for making GDHt and 1,3-PDDH were inserted into these bacteria, to produce the enzymes. When GDHt and 1,3-PDDH were produced together in a single bacterial cell, there was an indication that glycerol was being transformed into 1,3-PDO. However, the actual production of 1,3-PDO couldn’t be detected, and there were other factors affecting the me

During the COVID-19 pandemic, wastewater-based surveillance has been used alongside diagnostic testing to monitor infection rates. With the decline in cases reported to public health departments due to at-home testing, wastewater data may serve as the primary input for epidemiological models, but training these models is not straightforward. We explored factors affecting noise and bias in the ratio between wastewater and case data collected in 26 sewersheds in California from October 2020 to March 2022. The strength of the relationship between wastewater and case data appeared dependent on sampling frequency and population size, but was not increased by wastewater normalization to flow rate or case count normalization to testing rates. Additionally, the lead and lag times between wastewater and case data varied over time and space, and the ratio of log-transformed individual cases to wastewater concentrations changed over time. This ratio decreased between the Epsilon/Alpha and Delta variant surges of COVID-19 and increased during the Omicron BA.1 variant surge, and was also related to the diagnostic testing rate. Based on this analysis, we present a framework of scenarios describing the dynamics of the case to wastewater ratio to aid in data handling decisions for ongoing modeling efforts.

QC 20230526

Following a hybridization strategy, a series of 5-substituted-1H-indazoles were designed and evaluated in vitro as inhibitors of human monoamine oxidase (hMAO) A and B. Among structural modifications, the bioisostere-based introduction of 1,2,4-oxadiazole ring returned the most potent and selective human MAO B inhibitor (compound 20, IC50 = 52 nM, SI > 192). The most promising inhibitors were studied in cell-based neuroprotection models of SH-SY5Y and astrocytes line against H2O2. Moreover, preliminary drug-like features (aqueous solubility at pH 7.4; hydrolytic stability at acidic and neutral pH) were assessed for selected 1,2,4-oxadiazoles and compared to amide analogues through RP-HPLC methods. Molecular docking simulations highlighted the crucial role of molecular flexibility in providing a better shape complementarity for compound 20 within MAO B enzymatic cleft than rigid analogue 18. Enzymatic kinetics analysis along with thermal stability curves (Tm shift = +2.9 °C) provided clues of a tight-binding mechanism for hMAO B inhibition by 20.

Se realizó una búsqueda en la literatura especializada en enseñanza de la física (en español e inglés) revisando ejercicios, ejemplos y otros materiales didácticos con un enfoque forense. Si bien existen artículos especializados en esta área, no se encontró un libro de texto dedicado al ámbito forense, aunque sí existe un manual de prácticas. Se revisaron 27 libros de texto de física, mediante la exploración de palabras clave del quehacer forense y examinando si el contenido particular cumplía con cuatro criterios didácticos que se considera que definen la instrucción de la física forense: 1) enfoque en problemas inversos, 2) evitar conjeturas injustificadas, 3) uso de datos verosímiles y 4) empleo de una narrativa ético-forense. Solo 12 títulos cumplieron estos requisitos, al contar con mínimo una mención concreta, pero cuatro obras presentan más de cuatro casos puntuales de física forense. Los resultados sugieren que los temas forenses están subrepresentados en los libros de texto de física, en comparación con otros quehaceres. Esto implica una oportunidad para elaborar libros especializados en este contexto, implicando utilizar un recurso pedagógico con énfasis en situaciones reales, fomentadora de ciudadanía y atractiva para los estudiantes. Esta información fortalecerá los planes de estudio de las licenciaturas en ciencia forense y carreras afines.

Research experiences can benefit undergraduate students by providing hands-on experience in research, helping them develop critical thinking, problem-solving and analytical skills. Also, it helps them in establishing professional networking, career exploration, and demonstrable experience for future employers. In this article, the different types of undergraduate research experience that exist are explored. The article annotates several investigations of the benefits of undergraduate research experiences, including two that relate research experiences to the continuation into graduate school. This work also presents statistical data from the author’s university of affiliation, to conclude that undergraduate research is the strongest motivator there is for students to continue with graduate studies.

The emerging area of philosophy of birth is invaluable, first, to diagnose fallacious assump- tions about the relation between the womb and reason, and, ultimately, to challenge poten- tially damaging narratives with major impact on birth care. With its analysis of eighteenth- century epistemic and medical discussions about the role of the uterus in women’s reason- ing (or lack of reasoning), this article supports two arguments: first, that women’s “flawed thinking” was a premise drawn by many modern intellectual men, one that was presented as based upon empirical evidence; and second, that the pervasive construction of the uterus as an element that renders women wild, uncontrollable, and irrational continues to influence contemporary obstetrics (and maybe even to nurture obstetric violence), even as today’s medicine and science consider themselves to be free of any such prejudices. This article shows the role that Giacomo Casanova played in debunking these preju- dices and presents his short manuscript on the issue as an important contribution to the literature of the Enlightenment, with its argument against women’s supposed “natural” inferiority and for the idea that differences in education (rather than anatomical differ- ences) were to blame for women’s subordinate position in society. Detailed analysis of the “thinking uterus” debate illuminates the different ways in which various arguments from/by the “anti-uterine” lobby were used to justify the subor- dination of women: sometimes emphasizing the connection between the uterus and thought and sometimes negating it, but always concluding that women’s inferiority is to be found in some known or yet-to-be-discovered anatomical, and mainly sexual, defi- ciency or problem., Marie Skłodowska-Curie, Ministerio de Economía (España), Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub

A principios de los años 80 se desató en Francia una polémica conocida como «el silencio de los intelectuales». En este texto abordaremos la singular postura de Michel Foucault al respecto. Para ello realizaremos una doble operación. Por un lado, planteamos la hipótesis siguiente: se pueden encontrar los fundamentos que sostienen su posición en los análisis que realizó sobre la parrhesía a partir de los años 80. En segundo lugar, realizaremos un recorrido por autores como Lyotard y Blanchot, quienes intervinieron en dicha polémica con conocidos escritos, para mostrar las particularidades de la apuesta de Foucault. De esta manera, pretendemos, no solamente mostrar su original aportación al problema, sino señalar los desplazamientos respecto a la crítica del intelectual que había elaborado durante los años 70., During the 1980s, a controversy known as «the silence of intellectuals» broke out in France. In this article, we will address the unique position of Michel Foucault. In order to do this, we will move in two directions. Firstly, we will argue the following hypothesis: the foundation of his ideas in this polemic can be found in his analysis of parrhesia from the 1980s onwards. Secondly, we will look at authors such as Lyotard and Blanchot, who took part in the argument with well-known analysis, in order to point out the particularity of Foucault’s reflection. In this way, we attempt, not only to highlight his original contribution to the problem, but also to indicate the differences between this approach and his previous critique of the intellectual from the 1970s., Beca Iberoamérica-Santander Investigación, Fac. de Filosofía, TRUE, pub

El presente artículo constituye un aporte al conocimiento del arte en su vinculación con la filosofía y el psicoanálisis, en tanto aborda la tensión entre la representación y la construcción simbólica de la imagen artística en el contexto cultural/estético contemporáneo, mediantela relación entre lo Real lacaniano y la estática negativa de Adorno. Dicha relación encuentra su punto de articulación en el fenómeno estético de lo Bello, entendido como lo que encara al sujeto con el vacío de su deseo radical, sin engañarlo y que permite integrar la negatividad propia de lo Real con los elementos formales que componen la obra artística, así como con los conceptos de radicalidad y autenticidad de la propuesta adorniana. La articulación entre la estética negativa de Adorno y el efecto estético de lo Bellode Lacan, se ejemplifica con una interpretación en clave psicoanalítica de la obra de la artista colombiana Doris Salcedo., This article constitutes a contribution to the knowledge of art in its connection with philosophy and psychoanalysis, as it approaches to the tension between the representation and the symbolic construction of the artistic image in the contemporary cultural / aesthetic context, through the relationship between the Lacanian Real and Adorno's negative aesthetic. This relationship finds its articulation point in the aesthetic phenomenon of the Beautiful, understood as what confronts the subject with the emptiness of its radical desire, without deceiving it and that allows to integrate the Real ́s negativity with the formal elements that make up the artistic work, as well as the Adornian proposal concepts of radicality and authenticity. At the end, a psychoanalytic interpretation of colombian artist Doris Salcedo’s work is made, in which the negative aesthetics and the aesthetic effect of the Beautiful are integrated, Fac. de Filosofía, TRUE, pub

The Marie Skłodowska-Curie action "Controversies in Childbirth: from Epistemology to Practices (VOICEs) studies the gender, epistemic, and evaluative biases present in dominant discourses on childbirth from engaged philosophy. It aims at developing a values-based practice to be used in a variety of clinical contexts around childbirth. The project addresses the multiplicity of women´s voices on childbirth, their autonomy and agency. Partners: VOICEs is based at the Faculty of Philosophy of the University of Oxford. It is supported by The Collaborating Centre for Values-based Practice in Health at St Catherine’s College, Oxford. Other partners include the Research in Childbirth and Health group at the University of Central Lancashire, and the ERC Starting Grant BUMP at the University of Southampton. Leader: Stella Villarmea is Professor of Philosophy at the Complutense University of Madrid and Marie S. Curie Fellow at the University of Oxford. She investigates the Philosophy of Birth, i.e., how our notions of childbirth reflect our view of the human being. She is interested in the moral and political justification of our beliefs, the relationship between knowledge and emancipatory action, and conceptual innovation., Marie Skłodowska-Curie Individual Fellowship, Depto. de Lógica y Filosofía Teórica, Fac. de Filosofía, TRUE, pub